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51.
The distribution and retention of intravenously administered indium (113mInCl3) were determined in pregnant female rats. The highest accumulation of indium was found in the placenta during the last period of pregnancy. Five hours after administration the retention of indium in the placenta was about 38% of the administered dose. In the fetuses of these females the amount of radioactive indium did not exceed 1% of the injected dose. In the last period of pregnancy the placenta is the critical organ for intravenously administered administered indium (InCl3). 相似文献
52.
53.
Barbara Marciniak 《Hydrobiologia》1991,214(1):253-258
Diatom studies carried out in Central and Eastern Poland have shown a diversified composition and considerable changes of relative frequency of dominant diatoms in profiles of lake sediments of the Mazovian and Ferdynandovian interglacials. Cyclotella spp. are dominant in a large part of the sediment profiles at Adamówka, awki-7 and Wola Grzymalina-59 and, at Krpiec and Podlodów, Stephanodiscus is also common while at Biaa Podlaska and Falcice, Aulacoseira is most abundant. Cyclotella comta var. lichvinensis and C. vorticosa are the typical diatoms in the Mazovian Interglacial. In the sediments representing the Ferdynandovian Interglacial, the characteristic diatoms are Cyclotella cf. reczickiae and the Stephanodiscus rotula/niagarae complex. 相似文献
54.
HIV-1 Tat protein trans-activates transcription in vitro 总被引:55,自引:0,他引:55
55.
56.
R Marciniak 《Polski tygodnik lekarski (Warsaw, Poland : 1960)》1978,33(11):447-449
57.
BC Wilson D Burnett R Rappaport LJ Parry EK Fletcher 《Comparative biochemistry and physiology. Part A, Molecular & integrative physiology》2009,153(1):69-74
Relaxins are peptides similar in secondary structure to insulins. In teleost genomes, five or six relaxin genes have been identified. Two relaxins group closely with mammalian relaxin-3 on phylogenetic analysis and are named relaxin-3a and b. We refer to the remainder as relaxins c to f. Ovarian expression of relaxin-3a, d and f genes, and the relaxin-3 receptor gene Rxfp3, was studied in Danio rerio using RT-PCR. Immunohistochemistry was used to determine the distribution of relaxin-3 peptides and RXFP3 in the ovary of Fundulus heteroclitus (killifish). Thirdly, enzyme immunoassays and ovarian follicular culture were used to determine the effect of treatment with human recombinant relaxin-3 on the production of 17beta-estradiol and 17 alpha, 20 beta-dihydroxy-4-pregnen-3-one in killifish ovarian follicles. Relaxin-3a, d, f, and Rxfp3 genes were expressed regardless of sex or reproductive condition. Relaxin-3 immunostaining was present in mid to late follicular stages within cortical alveoli of the oocyte cytopasm, whereas receptor staining was localized to follicular cells. Treatment with relaxin-3 enhanced 17beta-estradiol production in early and late maturing follicles, but did not have an effect in vitellogenic follicles. Relaxin-3 appeared to suppress the release of MIS production. This suggests that relaxin peptides may be involved with estradiol-dependant events in follicular development. 相似文献
58.
Emilio Herrera Sonia del Campo Justyna Marciniak Julio Sevillano Maria Pilar Ramos 《Journal of physiology and biochemistry》2010,66(3):245-253
Adipose tissue normally has low glycerol kinase activity, but its expression is enhanced under conditions of augmented insulin
sensitivity and/or obesity. Since these conditions occur during early pregnancy, the comparative utilization of glucose or
glycerol by isolated adipocytes from rats at 0, 7, 14, or 20 days of pregnancy was studied. Incubations were carried out in
the presence of [U14C]-glucose or -glycerol in medium supplemented or not with 5 mM glucose and 100 nM insulin. The conversion of glucose into
esterified fatty acids and glyceride glycerol was greatest in adipocytes from 7-day pregnant rats, the effect being further
enhanced by insulin. Both the amount of aquoporin 7 and the in vitro conversion of glycerol into glyceride glycerol were greatest
in adipocytes of 7-day pregnant rats, the later being unaltered by insulin. In the presence of glucose, the overall glycerol
utilization was lower than in its absence and glycerol conversion into glyceride glycerol was further decreased by insulin,
the effect only being significant in adipocytes from 7-day pregnant rats. It is proposed that the enhanced utilization of
glycerol for glyceride glycerol synthesis in adipose tissue contributes to the net accumulation of fat depots that normally
takes place in early pregnancy. 相似文献
59.
The aim of the present study was to test the hypothesis about the relation between segregation of chromosomes 14 and 18 and the deterioration of mouse fertility and vitality. The analysis was possible because C-banding on chromosome 14 and chromosome 18 of the CBA/Kw and KE strains show size polymorphism. A small sized C-band on chromosome 14 is characteristic for the CBA/Kw mice, while the KE mice show small C-bands on chromosomes 18. Thus, if fertility parameters are affected in a centromere-dependent manner, we should observe non-random inheritance of both chromosome pairs in recombinant inbred (RI) strains. The results showed statistically significant preferential segregation of chromosomes 14 and 18 with small C-bands. Most of the RI strains inherited chromosome 14 from the CBA/Kw strain and chromosome 18 from the KE strain, and did not manifest a deterioration of fertility and vitality. On the contrary, RI strains that inherited chromosomes 14 and 18 from one of the parental strains, particularly the KE strain, stopped breeding or had difficulties in producing the next generation. 相似文献
60.
We examined the mechanism through which leptin increases Na+, K+-ATPase activity in the rat kidney. Leptin was infused under anaesthesia into the abdominal aorta proximally to the renal arteries and then Na+, K+-ATPase activity was measured in the renal cortex and medulla. Leptin (1 μg/kg min) increased Na+, K+-ATPase activity after 3 h of infusion, which was accompanied by the increase in urinary H2O2 excretion and phosphorylation level of extracellular signal regulated kinase (ERK). The effect of leptin on ERK and Na+, K+-ATPase was abolished by catalase, specific inhibitors of epidermal growth factor (EGF) receptor, AG1478 and PD158780, as well as by ERK inhibitor, PD98059, and was mimicked by both exogenous H2O2 and EGF. The effect of leptin was also prevented by the inhibitor of Src tyrosine kinase, PP2. Leptin and H2O2 increased Src phosphorylation at Tyr418. We conclude that leptin-induced stimulation of renal Na+, K+-ATPase involves H2O2 generation, Src kinase, transactivation of the EGF receptor, and stimulation of ERK. 相似文献