全文获取类型
收费全文 | 1429篇 |
免费 | 117篇 |
出版年
2024年 | 1篇 |
2023年 | 6篇 |
2022年 | 14篇 |
2021年 | 51篇 |
2020年 | 49篇 |
2019年 | 48篇 |
2018年 | 52篇 |
2017年 | 61篇 |
2016年 | 68篇 |
2015年 | 93篇 |
2014年 | 130篇 |
2013年 | 121篇 |
2012年 | 154篇 |
2011年 | 100篇 |
2010年 | 82篇 |
2009年 | 59篇 |
2008年 | 80篇 |
2007年 | 74篇 |
2006年 | 63篇 |
2005年 | 51篇 |
2004年 | 38篇 |
2003年 | 44篇 |
2002年 | 28篇 |
2001年 | 7篇 |
2000年 | 1篇 |
1999年 | 6篇 |
1998年 | 10篇 |
1997年 | 1篇 |
1996年 | 4篇 |
1995年 | 5篇 |
1994年 | 4篇 |
1993年 | 6篇 |
1992年 | 4篇 |
1991年 | 3篇 |
1990年 | 1篇 |
1989年 | 6篇 |
1988年 | 1篇 |
1987年 | 2篇 |
1985年 | 2篇 |
1984年 | 1篇 |
1981年 | 1篇 |
1980年 | 1篇 |
1979年 | 2篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1975年 | 4篇 |
1974年 | 3篇 |
1971年 | 1篇 |
排序方式: 共有1546条查询结果,搜索用时 15 毫秒
101.
102.
G Correia de Faria Santarém R de Cleva Marco Aurélio Santo Aline Biaseto Bernhard Alexandre Vieira Gadducci Julia Maria D’Andrea Greve Paulo Roberto Santos Silva 《PloS one》2015,10(6)
Background
Obesity is associated with mobility reduction due to mechanical factors and excessive body fat. The six-minute walk test (6MWT) has been used to assess functional capacity in severe obesity.Objective
To determine the association of BMI, total and segmental body composition with distance walked (6MWD) during the six-minute walk test (6MWT) according to gender and obesity grade.Setting
University of São Paulo Medical School, Brazil; Public Practice.Methods
Functional capacity was assessed by 6MWD and body composition (%) by bioelectrical impedance analysis in 90 patients.Results
The mean 6MWD was 514.9 ± 50.3 m for both genders. The male group (M: 545.2 ± 46.9 m) showed a 6MWD higher (p = 0.002) than the female group (F: 505.6 ± 47.9 m). The morbid obese group (MO: 524.7 ± 44.0 m) also showed a 6MWD higher (p = 0.014) than the super obese group (SO: 494.2 ± 57.0 m). There was a positive relationship between 6MWD and fat free mass (FFM), FFM of upper limps (FFM_UL), trunk (FFM_TR) and lower limbs (FFM_LL). Female group presented a positive relationship between 6MWD and FFM, FFM_UL and FFM_LL and male group presented a positive relationship between 6MWD and FFM_TR. In morbid obese group there was a positive relationship between 6MWD with FFM, FFM_UL, FFM_TR and FFM_LL. The super obese group presented a positive relationship between 6MWD with FFM, FFM_TR and FFM_LL.Conclusions
Total and segmental FFM is associated with a better walking capacity than BMI. 相似文献103.
104.
105.
Melanie Brügger Thomas Dmoulins G. Tuba Barut Beatrice Zumkehr Blandina I. Oliveira Esteves Kemal Mehinagic Quentin Haas Aline Schgler Marie-Anne Rameix-Welti Jean-Franois Elouët Ueli Moehrlen Thomas M. Marti Ralph A. Schmid Artur Summerfield Horst Posthaus Nicolas Ruggli Sean R. R. Hall Marco P. Alves 《PLoS pathogens》2021,17(7)
106.
Said El?Shamieh Marion Neuillé Angélique Terray Elise Orhan Christel Condroyer Vanessa Démontant Christelle Michiels Aline Antonio Fiona Boyard Marie-Elise Lancelot Mélanie Letexier Jean-Paul Saraiva Thierry Léveillard Saddek Mohand-Sa?d Olivier Goureau José-Alain Sahel Christina Zeitz Isabelle Audo 《American journal of human genetics》2014,94(4):625-633
107.
Oligopeptides are well‐known to self‐assemble into a wide array of nanostructures including β‐sheet‐rich fibers that when present above a critical concentration become entangled and form self‐supporting hydrogels. The length, quantity, and interactions between fibers influence the mechanical properties of the hydrogel formed and this is typically achieved by varying the peptide concentration, pH, ionic strength, or the addition of a second species or chemical cross‐linking agent. Here, we outline an alternative, facile route to control the mechanical properties of the self‐assembling octa‐peptide, FEFEFKFK (FEKII); simply doping with controlled quantities of its double length peptide, FEFEFKFK‐GG‐FKFKFEFE (FEKII18). The structure and properties of a series of samples were studied here (0–100 M% of FEKII18) using Fourier transform infrared, small angle X‐ray scattering, transmission electron microscopy, and oscillatory rheology. All samples were found to contain elongated, flexible fibers and all mixed samples contained Y‐shaped branch points and parallel fibers which is attributed to the longer peptide self‐assembling within two fibers, thus creating a cross‐link in the network structure. Such behavior was reflected in an increase in the elasticity of the mixed samples with increasing quantity of double peptide. Interestingly the elastic modulus increased up to 30 times the pure FEKII value simply by adding 28 M% of FEKII18. These observations provide an easy, off‐the‐shelf method for an end‐user to control the cross‐linked network structure of the peptide hydrogel, and consequently strength of the hydrogel simply by physically mixing pre‐determined quantities of two similar peptide molecules. © 2013 Wiley Periodicals, Inc. Biopolymers 101: 669–680, 2014. 相似文献
108.
109.
Diogo G. Garcia Lidia M. F. Amorim Mauro V. de Castro Faria Aline S. Freire Ricardo E. Santelli Clóvis O. Da Fonseca Thereza Quirico-Santos Patricia Burth 《Molecular and cellular biochemistry》2010,342(1-2):29-34
Indoleamine 2,3-dioxygenase (IDO) is an enzyme that suppresses adaptive T-cell immunity by catabolizing tryptophan from the cellular microenvironment. Inhibition of IDO pathway might enhance the efficacy of immunotherapeutic strategies for cancer. We synthesized 1-alkyl-tryptophan targeted IDO inhibitors and compared their effects on IDO expression and activity in dendritic cells (DCs) with the common IDO inhibitor 1-methyl-dl-tryptophan (1-MT). The IDO gene expression was examined by RT-PCR and realtime PCR. The toxicity of these analogs on the proliferation of DCs was detected by MTT assay. All of these analogs inhibited IDO expression and activity induced by IFN-γ and showed no cytotoxicity to DCs at 100 μM. 1-MT intensively suppressed IDO1 expression and activity in DCs, and 1-propyl-tryptophan (1-PT) and 1-isopropyl-tryptophan (1-isoPT) moderately inhibited them. 1-Butyl-tryptophan (1-BT) and 1-ethyl-tryptophan (1-ET) mainly inhibited IDO2 expression. Our results suggest that those analogs differed in their inhibitory activity on IDO expression may give us a clue for developing active IDO inhibitors. 相似文献