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排序方式: 共有350条查询结果,搜索用时 78 毫秒
341.
A. V. Grant A. Sabri A. Abid I. Abderrahmani Rhorfi M. Benkirane H. Souhi H. Naji Amrani K. Alaoui-Tahiri Y. Gharbaoui F. Lazrak I. Sentissi M. Manessouri S. Belkheiri S. Zaid A. Bouraqadi N. El Amraoui M. Hakam A. Belkadi M. Orlova A. Boland C. Deswarte L. Amar J. Bustamante S. Boisson-Dupuis J. L. Casanova E. Schurr J. El Baghdadi L. Abel 《Human genetics》2016,135(3):299-307
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Background
Natural selection eliminates detrimental and favors advantageous phenotypes. This process leaves characteristic signatures in underlying genomic segments that can be recognized through deviations in allelic or haplotypic frequency spectra. To provide an identifiable signature of recent positive selection that can be detected by comparison with the background distribution, we introduced a new way of looking at genomic polymorphisms: haplotype allelic classes. 相似文献345.
346.
Jmeii Leila Soufi Leila Abid Nabil Mahjoubi Mouna Roussos Sevastianos Ouzari Hadda I. Cherif Ameur Garna Haikel 《Annals of microbiology》2019,69(11):1177-1190
The agri-food industry generates significant amounts of byproducts, among them repasso olive pomace (ROP) which are rejected and can constitute a serious environmental problem. Our study aimed to investigate the diversity of microbiota isolated from ROP and screen for their biotechnological potentials. A collection of 102 strains (88 bacteria and 14 fungi) was obtained from a ROP sample. The diversity of the bacterial collection was evaluated by amplification of the internal transcribed spacers between the 16S and the 23S rRNA genes (ITS-PCR) and by 16S rRNA sequencing. Fungal identification was performed by polymerase chain reaction (PCR) amplification of the ITS1–5.8S–ITS2 ribosomal DNA region. The specific enzymatic screening of the detected microorganisms was tested. Partial 16S rRNA gene sequencing performed on 44 isolates showed a high level of identity with known strains. Fungal strains identification showed that they belong to four families: Trichocomaceae, Pleurostomataceae, Mucoraceae, and Bionectriaceae. Our results demonstrated that Gram-positive bacteria were mostly active, particularly for protease, lipase, amylase, cellulase laccase, and for biosurfactant production. From the 88 isolated bacteria, Firmicutes were the most prevalent and microdiverse. Bacillus and Paenibacillus, together with some other Gram-negative bacteria such as Pseudocitrobacter anthropi, and Acinetobacter johnsonii showed significant hydrolytic activities and biosurfactant production. The 14 isolated fungi showed a high capacity of enzyme production. This is the first study in Tunisia describing the microbial diversity in ROP as well as the isolation of Bacillus mojavensis producing lipase. Microorganisms especially fungi present in the repasso olive cake produce diverse hydrolytic enzymes of industrial interest. 相似文献
347.
Benjamin Weiss George Edward Allen Joachim Kloehn Karim Abid Pascale Jaquier-Gubler Joseph Alphonsus Curran 《Nucleic acids research》2021,49(9):5159
The eIF4E are a family of initiation factors that bind the mRNA 5′ cap, regulating the proteome and the cellular phenotype. eIF4E1 mediates global translation and its activity is controlled via the PI3K/AKT/mTOR pathway. mTOR down-regulation results in eIF4E1 sequestration into an inactive complex with the 4E binding proteins (4EBPs). The second member, eIF4E2, regulates the translatome during hypoxia. However, the exact function of the third member, eIF4E3, has remained elusive. We have dissected its function using a range of techniques. Starting from the observation that it does not interact with 4EBP1, we demonstrate that eIF4E3 recruitment into an eIF4F complex occurs when Torin1 inhibits the mTOR pathway. Ribo-seq studies demonstrate that this complex (eIF4FS) is translationally active during stress and that it selects specific mRNA populations based on 5′ TL (UTR) length. The interactome reveals that it associates with cellular proteins beyond the cognate initiation factors, suggesting that it may have ‘moon-lighting’ functions. Finally, we provide evidence that cellular metabolism is altered in an eIF4E3 KO background but only upon Torin1 treatment. We propose that eIF4E3 acts as a second branch of the integrated stress response, re-programming the translatome to promote ‘stress resistance’ and adaptation. 相似文献
348.
Michael Merrick Michael J. Mimlitz Catherine Weeder Haris Akhter Allie Bray Andrew Walther Chisom Nwakama Joe Bamesberger Honour Djam Kaamil Abid Andrew Ekpenyong 《Biochemistry and Biophysics Reports》2021
Although radiotherapy and most cancer drugs target the proliferation of cancer cells, it is metastasis, the complex process by which cancer cells spread from the primary tumor to other tissues and organs of the body where they form new tumors, that leads to over 90% of all cancer deaths. Thus, there is an urgent need for anti-metastasis strategies alongside chemotherapy and radiotherapy. An important step in the metastatic cascade is migration. It is the first step in metastasis via local invasion. Here we address the question whether ionizing radiation and/or chemotherapy might inadvertently promote metastasis and/or invasiveness by enhancing cell migration. We used a standard laboratory irradiator, Faxitron CellRad, to irradiate both non-cancer (HCN2 neurons) and cancer cells (T98G glioblastoma) with 2 Gy, 10 Gy and 20 Gy of X-rays. Paclitaxel (5 μM) was used for chemotherapy. We then measured the attachment and migration of the cells using an electric cell substrate impedance sensing device. Both the irradiated HCN2 cells and T98G cells showed significantly (p < 0.01) enhanced migration compared to non-irradiated cells, within the first 20–40 h following irradiation with 20 Gy. Our results suggest that cell migration should be a therapeutic target in anti-metastasis/anti-invasion strategies for improved radiotherapy and chemotherapy outcomes. 相似文献
349.
Bie Jia Zheng Keren Gao Xiang Liu Boyang Ma Jun Hayat Muhammad Abid Xiao Jianhua Wang Hongbin 《EcoHealth》2021,18(1):3-12
EcoHealth - Chytridiomycosis, a leading cause for the global decline in the number of amphibians, is caused by the fungal pathogen Batrachochytrium dendrobatidis. In this study, global distribution... 相似文献
350.
Abid Hussain Ming-Yi Tian Yu-Rong He Yan-Yuan Lei 《Journal of invertebrate pathology》2010,104(3):166-171
Insect-passaged cultures of entomopathogenic fungi grown on potato dextrose agar media have been shown to have altered virulence and profiles of volatile compounds. The present study demonstrated the pathogenic status of FS0 (in vitro) and FS1 and FS2 (insect-passaged cultures grown on PDA) cultures of Metarhizium anisopliae (strains 406 and 02049) and Beauveria bassiana by a non-choice assay, in which filter paper was inoculated with fungal spores at a concentration of 1 × 107 spores/ml. The FS1 and FS2 cultures of M. anisopliae strain 02049 and B. bassiana produced conidia with high virulence, and the volatile profiles of these conidia comprised relatively lower percentages of branched-alkanes than conidia from the FS0 cultures. In contrast, the conidia from an FS0 culture of M. anisopliae strain 406 had somewhat elevated virulence levels, but their volatile profile had <2% branched-alkanes. The FS1 and FS2 cultures of M. anisopliae strain 406 did not gain virulence, and these cultures showed a decline in virulence along with major alteration of their volatile profiles. Their volatile profiles mainly comprised branched-alkanes. The volatile profiles of the FS1 and FS2 cultures lacked n-tetradecane, which was an important component of all the virulent cultures. Four compounds, 2-phenylpropenal, 2,5,5-trimethyl-1-hexene, n-tetradecane and 2,6-dimethylheptadecane, were detected only from the virulent cultures, suggesting that low LT50 values were probably due to the production of these compounds. This is the first report to characterize volatiles from FS0, FS1 and FS2 cultures of entomopathogenic fungi; its utility in different aspects opens an interesting area for further investigations. 相似文献