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51.
SUN Xiangqing * JIA Yanbin * ZHANG Xuegong XU Qi SHEN Yan & LI Yanda . Ministry of Education 《中国科学:生命科学英文版》2005,48(3):263-269
Schizophrenia is a serious neuropsychiatric illness affecting about 1% of the world’s population. Family, twin and adoption studies have demonstrated that 65%―85% of the susceptibility to schizophrenia can be attributed to genes. On the basis of genetic model-ing of epidemiological data and recent results of a number of whole-genome screens for susceptibility genes, schizophrenia has been considered a complex disorder. A number of genes with small to moderate effects are involved in combinat… 相似文献
52.
CHEN Ruijuan JIANG Jiangang XIAO Xiao & WANG Daowen . The Institute of Hypertension Department of Internal Medicine Tongji Hospital Tongji Medical College Huazhong University of Science & Technology Wuhan China . Departments of Molecular Genetics Biochemistry & Gene Therapy Center University of Pittsburgh Pittsburgh PA USA 《中国科学:生命科学英文版》2005,48(5):495-505
Vascular endothelial cells play crucial roles in regulating cardiovascular function, maintaining car-diovascular homeostasis and preventing the occur-rence of cardiac and cerebral vascular diseases. All these protective effects are fulfilled through various vasoactive products secreted by endothelium including nitric oxide (NO), prostacyclin (PGI2) and endothe-lium-derived hyperpolarizing factor (EDHF). NO, pro-duced from L-arginine by endothelial nitric-oxide synthase (eNOS), is an impor… 相似文献
53.
REN Yuanyuan DAI Xiuyu ZHOU Jian LIU Jingfang PEI Huadong & XIANG Hua . State Key Laboratory of Microbial Resources Center for Molecular Microbiology Institute of Microbiology Chinese Academy of Sciences Beijing China . Graduate School of Chinese Academy of Sciences Beijing China 《中国科学:生命科学英文版》2005,48(3):221-227
Trehalose is a non-reducing disaccharide of glucosewidely distributed in microorganisms, plants and in-sects. It usually functions as a compatible solute in thestabilization of biological structures under several en-vironment stresses[1,2]. Trehalose has proved to be anactive stabilizer of enzymes, proteins, biomasses, pharmaceutical preparations and even organs fortransplantation. Thus much attention has been paid tothe synthesis pathway of trehalose and the develop-ment of novel and economic… 相似文献
54.
Tyroserleutide tripeptide affects calcium homeostasis of human hepatocarcinoma BEL-7402 cells 总被引:1,自引:0,他引:1
FU Zheng LU Rong LI Guoli ZHAO Lan GAO Weizhen CHE Xuchun JIAN Xu ZHOU Chunlei & YAO Zhi . Department of Immunology Tianjin Medical University Tianjin China . Shenzhen Kangzhe Pharmaceutical Co. Ltd. Shenzhen China . Department of Pharmacy Tianjin Medical University Tianjin China . Central Laboratory of Tianjin Medical University Hospital Tianjin China 《中国科学:生命科学英文版》2005,48(5):523-530
Copyright by Science in China Press 2005 Primary hepatocarcinoma is one of the most fre-quent digestive-tract cancers, particularly in China. The incidence and death rate of primary hepatocarci-noma in China is the highest in the world, with about 1100 thousands people dying from primary hepatocar-cinoma per year[1]. Although the chemotherapeutic agents are the main therapeutic approach for hepato- carcinoma, they are relatively ineffective and result in many toxic and side effects. Accordin… 相似文献
55.
Comparative analysis of the pig BAC sequence involved in the regulation of myostatin gene 总被引:2,自引:2,他引:0
YU Zhengquan LI Yan MENG Qingyong YUAN Jing ZHAO Zhihui LI Wei HU Xiaoxiang YAN Bingxue FAN Baoliang YU Shuyang & LI Ning .State Key Laboratory for Agrobiotechnology China Agricultural University Beijing China .Beijing Genomics Institute / Genomics Bioinformatics Center Institute of Genetics Development Biology Chinese Academy of Sciences Beijing China 《中国科学:生命科学英文版》2005,48(2):168-180
Myostatin (GDF-8, MSTN) is a member of trans- forming growth factors (TGF-β) superfamily, which was first described by McPherron et al. in 1997[1]. Myostatin appears to act as a negative regulator of muscle development and controls not only fibre size but also fibre number[2,3]. Mutations in the third exon of the myostatin gene have been shown to cause dou- ble muscling in cattle[4]. By knocking out the gene of myostatin in mice, they were able to show that the transgenic mice developed … 相似文献
56.
MENG Yan ZHAO ChunYan ZHANG XueXin ZHAO HuaShan GUO LiRong Lü Bin ZHAO XueJian& YANG BaoXue Department of Pathophysiology School of Basic Medicine Jilin University Changchun China Department of Physiology Department of Medicine University of California San Francisco CA USA 《中国科学:生命科学英文版》2009,52(5):474-478
57.
互作对水稻白叶枯病菌JXOⅢ和JXOⅤ超氧阴离子释放的调控 总被引:2,自引:0,他引:2
水稻白叶枯病菌能够引起水稻的白叶枯病等一系列水稻病害。水稻白叶枯病菌JXOⅢ和JXOⅤ细胞中超氧阴离子的释放水平存在显著的差异,并进一步显示在两者亚细胞组分的超氧阴离子释放水平上。这种差异暗示致病性不同的病原菌中,O2^-可能具有信号传导及毒性因子的不同作用。亲和性不同的植物一病原菌互作过程对病原菌JXOⅢ和JXOⅤ的超氧阴离子释放具有不同的调控作用。对自身O2^-水平很低的JXOⅢ来说,亲和互作和非亲和互作过程都可诱导JXOⅢ中O2^-的释放;然而在自身听水平较高的JXOⅤ中,则随亲和性不同而表现出诱导或抑制的不同调控作用。无论是在JXOⅢ还是在JXOⅤ中,互作后分离得到的病原菌仍然能够显示出互作对其O2^-释放的显著影响,这种调控作用很可能具有一定的遗传稳定性。虽然机制还不清楚,但是推测这种调控可能和互作的走向相关。 相似文献
58.
干旱与条锈病复合胁迫对小麦的生理影响 总被引:1,自引:0,他引:1
以抗旱性和抗病性不同的小麦为材料,以正常生长为对照,观察了病原菌和水分复合胁迫对小麦叶片相对含水量、活性氧代谢以及对抗氰呼吸的发生、运行的影响。讨论了在干旱与病原菌侵染复合胁迫下,抗氰呼吸在植物抗逆机制中所扮演的角色。复合胁迫下,抗病小麦显然具备更强的水分调控能力,而感病品种不能有效控制病叶水分散失。水分胁迫能引起抗氰呼吸的下降,但不能抵消因病原菌侵染引起的抗氰呼吸的增强,条锈菌侵染对小麦抗氰呼吸的影响远远大于水分胁迫。病原菌侵染和水分复合胁迫下,活性氧产生的速率表现出累加效应,而抗氰呼吸表现出和基质抗氧化酶的活性互补。植物交替氧化酶在干旱与病原菌侵染复合胁迫中具有重要的抗氧化功能,并可能调节着逆境下物质与能量需求间的矛盾。 相似文献
59.
China is one of the countries in the world with therichest species biodiversityinfreshwater ecosystem.How-ever,duetothe rapid economic growthandthe continuingincrease of human disturbances and destructions of aquatichabitats,the biodiversity of freshwater ecosystemsis dras-tically declining.Waterbodies become more and more“deserted”of sensitive species.Water areas are reduced,fragmentized,and changed in their hydrodynamics(i.e.damming),causing changes in sedimentation and otherchanges.Forinstance,the area o... 相似文献
60.