石蒜碱通过激活AMPK通路和下调MMP9促进雪旺细胞自噬改善神经功能

糖尿病周围神经病变(DPN)是糖尿病最常见的并发症,也是最常见的神经系统疾病。DPN患者有多种表现,包括大神经纤维损伤引起的感觉丧失和肌肉无力,小神经纤维损伤引起的感觉迟钝、疼痛、麻木和植物神经症状。严重时,DPN还会导致剧烈疼痛和皮肤溃疡,甚至威胁患者生命。然而目前尚无批准用于治疗DPN的药物。     

QUANTITATIVE ANALYSIS IN THE RESEARCH OF TEACHING

TheauthorconslstentlythlnkthatagreatdealofinfromationisIncludedintbescoreofstudent’sexamination，whichcanbeusedInthequantitativeanalysisofteachingandstudyingproblemsonmanyaspects．Soseveralstatlstlca！methodshavebeenusedInthestudyofteachingactivitybythea…     

CLUSTERING POPULATIONS BY MIXED LINEAR MODELS

INTRODUCTIONInevolutionstudiesandplant(oranimal)breedingresearch,clusteranalysesarewidelyusedforgroupingpopulations.Therehavebeenalotofmethodsdevelopedforgroupingpopulations(SneathandSokal,1973;Eve-ritt,1993).Variousmethodsaredifferedinthewaysfordistance(…     

基于串联紫外/带电气溶胶检测和相似性分析建立生脉胶囊的色谱指纹图谱CSCD

色谱指纹图谱具有表征复杂化学系统组成的能力,已被广泛用作植物药产品质量控制的有力手段。相似性分析是指纹数据分析中最常用的质量一致性评价方法,通过将样本与标准指纹进行比较并评估样本之间相似性的一种方法。然而相似性分析灵敏度低,不适合小样本数据集的质量评估,且相似性分析指标阈值设置通常为主观值,如0.85或0.90,缺乏统计依据。因此,基于相似性分析建立一种新的分析方法显得尤为重要。     

Association between VDR Apal Polymorphism and Hip Bone Mineral Density Can Be Modified by Body Mass Index:A Study on Postmenopausal Chinese Women

Osteoporosis is a major public health problem for old people.Genetic factors are considered tobe major contributors to the pathogenesis of postmenopausal osteoporosis.The vitamin D receptor(VDR)gene is a prominent candidate gene for the regulation of postmenopausal bone mass;however,despite exten-sive studies,controversy remains regarding its association with postmenopausal body mineral density(BMD)variation.In this study,a total of 260 healthy postmenopausal Chinese women were genotyped at the VDRApaI locus using polymerase chain reaction(PCR)-restriction fragment length polymorphism (RFLP).Rawhip BMD was significantly associated with VDR ApaI polymorphism with and without adjusting for age(P=0.015 and 0.040,respectively).This genetic effect can explain 3.32% of hip BMD variation.However,the significant association vanished after correcting for both age and body mass index(BMI)(P=0.169).Inaddition,we observed a significant association between VDR ApaI polymorphism with unadjusted BMI(P=0.042)or BMI adjusted for age(P=0.049).The raw hip BMD was also found to be significantly corre-lated with BMI(r=0.517,P=0.0001),with BMI explaining 26.35% of the variation of hip BMD.All of thesefacts prompt us to conclude that the significant association between the VDR ApaI genotype and hip BMDmay be modified by BMI in postmenopausal Chinese women.Our findings may partially explain the earlierinconsistent association results concerning the VDR gene and BMD,and highlight the importance of incorpo-rating covariates such as BMI into osteoporosis association studies.