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  总被引:4,自引:0,他引:4  
Despite growing interest in the effects of landscape heterogeneity on genetic structuring, few tools are available to incorporate data on landscape composition into population genetic studies. Analyses of isolation by distance have typically either assumed spatial homogeneity for convenience or applied theoretically unjustified distance metrics to compensate for heterogeneity. Here I propose the isolation-by-resistance (IBR) model as an alternative for predicting equilibrium genetic structuring in complex landscapes. The model predicts a positive relationship between genetic differentiation and the resistance distance, a distance metric that exploits precise relationships between random walk times and effective resistances in electronic networks. As a predictor of genetic differentiation, the resistance distance is both more theoretically justified and more robust to spatial heterogeneity than Euclidean or least cost path-based distance measures. Moreover, the metric can be applied with a wide range of data inputs, including coarse-scale range maps, simple maps of habitat and nonhabitat within a species' range, or complex spatial datasets with habitats and barriers of differing qualities. The IBR model thus provides a flexible and efficient tool to account for habitat heterogeneity in studies of isolation by distance, improve understanding of how landscape characteristics affect genetic structuring, and predict genetic and evolutionary consequences of landscape change.  相似文献   
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The maintenance of soil organic matter (SOM) and the balancing of nutrient flows into and out of the rainfed rice cropping systems in Northeast Thailand is of paramount importance to arresting the decline in soil fertility and crop yields. A system where small applications of leaf litters from locally grown trees are applied annually to rice paddy soils prior to transplanting is described. The annual application of 1500 kg/ha of Cajanus cajan, Acacia auriculiformis, Phyllanthus taxodifolius and Samanea saman for five seasons resulted in increases in rice grain yield of 48, 35, 32 and 23% above the no-leaf litter control, respectively. Average annual nutrient inputs from the leaf litters, in kg/ha, ranged from 62.7 N, 3.9 P, 17.9 K, and 3.5 S for Cajanus cajan to 24.5 N, 1.5 P, 8.1 K and 2.0 S for Acacia auriculiformis. Nutrient balances, determined by the difference between the inputs (fertiliser and added leaf litters) and outputs (grain and straw) indicated net positive N and P balances of up to 457 and 60 kg/ha. respectively, after five seasons of leaf litter applications. Sulfur and potassium balances resulted in net deficits of up to −3 and −52 kg S and K/ha, respectively, where no leaf litter was applied and rice straw was removed following harvest. Calculated apparent nutrient recoveries reflected the decomposition rate of the added residues and were highest for P and K, reflecting their higher soil residual value than mobile nutrients such as N and S. Sustainable farming systems will require that crop yields are stable through the maintenance of soil fertility and the balance of nutrients in the system. This revised version was published online in June 2006 with corrections to the Cover Date.  相似文献   
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We consider the directed evolution of a population after an intervention that has significantly altered the underlying fitness landscape. We model the space of genotypes as a distributive lattice; the fitness landscape is a real-valued function on that lattice. The risk of escape from intervention, i.e., the probability that the population develops an escape mutant before extinction, is encoded in the risk polynomial. Tools from algebraic combinatorics are applied to compute the risk polynomial in terms of the fitness landscape. In an application to the development of drug resistance in HIV, we study the risk of viral escape from treatment with the protease inhibitors ritonavir and indinavir.  相似文献   
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