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排序方式: 共有288条查询结果,搜索用时 15 毫秒
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( Dept.of Math. Faculty of Science Mansoura Egypt Dept.of Math. Faculty of Education Kafr El-Sheikh Tanta University Egypt.) 《生物数学学报》1997,(3)
1IntreductionTheliteratUreonmulti-Criteriondecisionmaking(MCDM)problemshas~tremendouslyintherecentpast.TwomajorareashaveevolvedwhiChbothconcentrateondecisionmakingwithseveralcriteria:multiobjectivedecisionmaking(MODM)andmulti-attributedecisionmaking(MADM).TheformerconcentratesoncontinuousdecisionspaceandthelatterfocusesonproblemswithdiscreteSPace.FuzzysettheoryhascontributedtoMODMproblemsaswellastheMADMProblems.ThegeneralMODMproblemcanbedeft.edLllasfollows:Twostagescangenerallybe… 相似文献
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ZHU JINGDE 《Cell research》1995,(1)
INTanDUCTI0NMyeloidcelldifferentiati0n,inwhichmultip0tentialprogenitorcellsarec0nvertedint00neofthesixmaturedifferentiatedcells,i.e.,erythr0cytes,platelets(megakary-ocytes),macr0phages,neutr0phils,e0sinophilsandbas0phils,involvestemporalre-gulati0nofexpression0fanumberoflineage-anddifferentiationstage-specificgenes.Understandingthedevel0pmentalspecificationoflineageaJswellasmaturationstageassociatedpatterns0fgeneexpressioninmyel0idcelldifferentiationrequiresanin-sightintothecontrol0findivid… 相似文献
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C Xie Xc ZS Zhou X Xae Xee N Li Xe Y Bian X YJ Wang Xb Xc Xefa LJ Wang Xb Xed Xaf BL Li Xe Xff Xf BL Song Xbb Xfdd Xeae 《Journal of lipid research》2012,53(10):2092-2101
The multiple transmembrane protein Niemann-Pick C1 like1 (NPC1L1) is essential for intestinal cholesterol absorption. Ezetimibe binds to NPC1L1 and is a clinically used cholesterol absorption inhibitor. Recent studies in cultured cells have shown that NPC1L1 mediates cholesterol uptake through vesicular endocytosis that can be blocked by ezetimibe. However, how NPC1L1 and ezetimibe work in the small intestine is unknown. In this study, we found that NPC1L1 distributed in enterocytes of villi and transit-amplifying cells of crypts. Acyl-CoA cholesterol acyltransferase 2 (ACAT2), another important protein for cholesterol absorption by providing cholesteryl esters to chylomicrons, was mainly presented in the apical cytoplasm of enterocytes. NPC1L1 and ACAT2 were highly expressed in jejunum and ileum. ACAT1 presented in the Paneth cells of crypts and mesenchymal cells of villi. In the absence of cholesterol, NPC1L1 was localized on the brush border of enterocytes. Dietary cholesterol induced the internalization of NPC1L1 to the subapical layer beneath the brush border and became partially colocalized with the endosome marker Rab11. Ezetimibe blocked the internalization of NPC1L1 and cholesterol and caused their retention in the plasma membrane. This study demonstrates that NPC1L1 mediates cholesterol entering enterocytes through vesicular endocytosis and that ezetimibe blocks this step in vivo. 相似文献
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GUO DENG FU YU LIN SUN PAVEL HAMET TADASHI INAGAMI Research Centre Hotel-Dieu of CHUM Department of Medicine University of Montreal Montreal Quebec Canada HW T Department of Biochemistry Vanderbilt University School of Medicine Nashville 《Cell research》2001,(3)
INTRODUCTIONThe renin-angiotensin system (RAS) is consid-ered to be the major regulator of blood pressure)electrolyte balance and renal, neuronal as well as en-docrine functions related to cardiovascular control.The RAS is the key factor in most cases essential hy-pertension, as indicated by successes in treatment ofhypertensive patients with various angiotensin I con-verting enzyme (ACE) inhibitors and receptor block-ers. Renin was a central subject of intense investigation because of… 相似文献
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The complete mitochondrial genomes sequences of Asio flammeus and Asio otus and comparative analysis 总被引:2,自引:0,他引:2
SUN Yi MA Fei XIAO Bing ZHENG Junjie YUAN Xiaodong TANG Minqian WANG Li YU Yefei & Li Qingwei . College of Life Sciences Liaoning Normal University Dalian China . TaKaRa Biotechnology 《中国科学:生命科学英文版》2004,47(6):510-520
Mitochondrial DNA (mtDNA), as a model sys-tem, has been extensively used for molecular phy-logenetic and evolutionary analysis[1]. With the ad-vances in DNA sequencing technology, more andmore researchers prefer to use complete mitochondrialgenome for phylogenetic analysis[2—4]. Since the com-plete sequencing of human mtDNA in 1981 (Andersonet al., 1981)[5], 342 vertebrate mitochondrial genomeshave so far been sequenced. Up to now the completesequences of 29 avian mitochondrial genomes h… 相似文献
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Hamdan FF Gauthier J Araki Y Lin DT Yoshizawa Y Higashi K Park AR Spiegelman D Dobrzeniecka S Piton A Tomitori H Daoud H Massicotte C Henrion E Diallo O;SD Group Shekarabi M Marineau C Shevell M Maranda B Mitchell G Nadeau A D'Anjou G Vanasse M Srour M Lafrenière RG Drapeau P Lacaille JC Kim E Lee JR Igarashi K Huganir RL Rouleau GA Michaud JL 《American journal of human genetics》2011,(3):1427-316
Little is known about the genetics of nonsyndromic intellectual disability (NSID). We hypothesized that de novo mutations (DNMs) in synaptic genes explain an important fraction of sporadic NSID cases. In order to investigate this possibility, we sequenced 197 genes encoding glutamate receptors and a large subset of their known interacting proteins in 95 sporadic cases of NSID. We found 11 DNMs, including ten potentially deleterious mutations (three nonsense, two splicing, one frameshift, four missense) and one neutral mutation (silent) in eight different genes. Calculation of point-substitution DNM rates per functional and neutral site showed significant excess of functional DNMs compared to neutral ones. De novo truncating and/or splicing mutations in SYNGAP1, STXBP1, and SHANK3 were found in six patients and are likely to be pathogenic. De novo missense mutations were found in KIF1A, GRIN1, CACNG2, and EPB41L1. Functional studies showed that all these missense mutations affect protein function in cell culture systems, suggesting that they may be pathogenic. Sequencing these four genes in 50 additional sporadic cases of NSID identified a second DNM in GRIN1 (c.1679_1681dup/p.Ser560dup). This mutation also affects protein function, consistent with structural predictions. None of these mutations or any other DNMs were identified in these genes in 285 healthy controls. This study highlights the importance of the glutamate receptor complexes in NSID and further supports the role of DNMs in this disorder. 相似文献