IL-33 causes thermogenic failure in aging by expanding dysfunctional adipose ILC2

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DRAK2 contributes to type 1 diabetes by negatively regulating IL-2 sensitivity to alter regulatory T cell development

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Th1-Th2 Cross-Regulation Controls Early Leishmania Infection in the Skin by Modulating the Size of the Permissive Monocytic Host Cell Reservoir

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Tumor-Derived Lactic Acid Contributes to the Paucity of Intratumoral ILC2s

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Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity

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CCL2 and CXCL12 Derived from Mesenchymal Stromal Cells Cooperatively Polarize IL-10+ Tissue Macrophages to Mitigate Gut Injury

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Enteric helminth coinfection enhances host susceptibility to neurotropic flaviviruses via a tuft cell-IL-4 receptor signaling axis

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An epithelial-immune circuit amplifies inflammasome and IL-6 responses to SARS-CoV-2

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Stem-like intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity

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Single-cell RNA sequencing identifies a population of human liver-type ILC1s

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Type 2 cytokines promote angiogenesis in ischemic muscle via endothelial IL-4Rα signaling

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Il4ra-independent vaginal eosinophil accumulation following helminth infection exacerbates epithelial ulcerative pathology of HSV-2 infection

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Annexin A1 is a cell-intrinsic metalloregulator of zinc in human ILC2s

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A local regulatory T cell feedback circuit maintains immune homeostasis by pruning self-activated T cells

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Microbiota imbalance induced by dietary sugar disrupts immune-mediated protection from metabolic syndrome

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Human skeletal muscle CD90+ fibro-adipogenic progenitors are associated with muscle degeneration in type 2 diabetic patients

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Pyruvate dehydrogenase fuels a critical citrate pool that is essential for Th17 cell effector functions

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DUX-miR-344-ZMYM2-Mediated Activation of MERVL LTRs Induces a Totipotent 2C-like State

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T-bet+ B cells accumulate in adipose tissue and exacerbate metabolic disorder during obesity

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Sterile liver injury induces a protective tissue-resident cDC1-ILC1 circuit through cDC1-intrinsic cGAS-STING-dependent IL-12 production

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