共查询到10条相似文献,搜索用时 62 毫秒
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Marianne Lucas-Hourani Daniel Dauzonne Pierre Jorda Ga?lle Cousin Alexandru Lupan Olivier Helynck Grégory Caignard Geneviève Janvier Gwéna?lle André-Leroux Samira Khiar Nicolas Escriou Philippe Desprès Yves Jacob Hélène Munier-Lehmann Frédéric Tangy Pierre-Olivier Vidalain 《PLoS pathogens》2013,9(10)
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Jamie C. Snyder Susan K. Brumfield Keshia M. Kerchner Tessa E. F. Quax David Prangishvili Mark J. Young 《Journal of virology》2013,87(4):2186-2192
Archaeal host cells infected by Sulfolobus turreted icosahedral virus (STIV) and Sulfolobus islandicus rod-shaped virus 2 (SIRV2) produce unusual pyramid-like structures on the cell surface prior to virus-induced cell lysis. This viral lysis process is distinct from known viral lysis processes associated with bacterial or eukaryal viruses. The STIV protein C92 and the SIRV2 protein 98 are the only viral proteins required for the formation of the pyramid lysis structures of STIV and SIRV2, respectively. Since SIRV2 and STIV have fundamentally different morphotypes and genome sequences, it is surprising that they share this lysis system. In this study, we have constructed a collection of C92/P98 chimeric proteins and tested their abilities, both in the context of virus replication and alone, to form pyramid lysis structures in S. solfataricus. The results of this study illustrate that these proteins are functionally homologous when expressed as individual chimeric proteins but not when expressed in the context of complete STIV infection. 相似文献
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Li Xing Tian-Cheng Li Naoyuki Mayazaki Martha N. Simon Joseph S. Wall Mary Moore Che-Yen Wang Naokazu Takeda Takaji Wakita Tatsuo Miyamura R. Holland Cheng 《The Journal of biological chemistry》2010,285(43):33175-33183
Hepatitis E virus (HEV) induces acute hepatitis in humans with a high fatality rate in pregnant women. There is a need for anti-HEV research to understand the assembly process of HEV native capsid. Here, we produced a large virion-sized and a small T=1 capsid by expressing the HEV capsid protein in insect cells with and without the N-terminal 111 residues, respectively, for comparative structural analysis. The virion-sized capsid demonstrates a T=3 icosahedral lattice and contains RNA fragment in contrast to the RNA-free T=1 capsid. However, both capsids shared common decameric organization. The in vitro assembly further demonstrated that HEV capsid protein had the intrinsic ability to form decameric intermediate. Our data suggest that RNA binding is the extrinsic factor essential for the assembly of HEV native capsids. 相似文献
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目的:研究视网膜母细胞瘤结合蛋白6(RbBP6)对TNF-α激活的NF-KB转录活性的影响。方法:构建RbBP6的真核表达载体并在293T细胞中过表达,或利用RNA干扰技术敲低RbBP6的表达,采用NF-KB双萤光素酶报告系统检测RbBP6对TNF-α激活的NF-KB转录活性的影响。结果:过表达RbBP6对NF-KB转录活性无明显影响,而瞬时干扰RbBP6能够明显抑制NF-KB的转录活性。结论:实验结果提示RbBP6在NF-KB信号通路中可能发挥重要调控作用。 相似文献
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Lowell A. Glasgow 《The Journal of general physiology》1970,56(1):212-226
Interferon is one determinant of host resistance. The immune responses, cellular or humoral, are other components. Cell-mediated responses appear to be involved in host resistance to certain viral infections, particularly the herpesvirus group and vaccinia virus. It is suggested that immune and interferon responses may complement one another and contribute to host resistance. The relative importance of each component depends upon the virus-host interaction. Finally, evidence has been presented which suggests that production of interferon as a result of antigen-sensitized cell interaction may further link these two components of the host response. 相似文献
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Xianfang Wu Viet Loan Dao Thi Yumin Huang Eva Billerbeck Debjani Saha Hans-Heinrich Hoffmann Yaomei Wang Luis A. Vale Silva Stephanie Sarbanes Tony Sun Linda Andrus Yingpu Yu Corrine Quirk Melody Li Margaret R. MacDonald William M. Schneider Xiuli An Brad R. Rosenberg Charles M. Rice 《Cell》2018,172(3):423-438.e25
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Siroon Bekkering Rob J.W. Arts Boris Novakovic Ioannis Kourtzelis Charlotte D.C.C. van der Heijden Yang Li Calin D. Popa Rob ter Horst Julia van Tuijl Romana T. Netea-Maier Frank L. van de Veerdonk Triantafyllos Chavakis Leo A.B. Joosten Jos W.M. van der Meer Henk Stunnenberg Niels P. Riksen Mihai G. Netea 《Cell》2018,172(1-2):135-146.e9