“工业微生物学”课程线上教学的改革与实践

为了保证新型冠状病毒肺炎疫情下的教学质量,我们教学团队通过重构教学体系和教学过程设计,进行了“工业微生物学”课程教学改革的探索。基于超星泛雅网络教学平台,建立集网络课堂和数字化资源为一体的智能教学体系,改革教学过程的设计与实施途径,探讨“线上”教学的考核模式,评价教学改革效果。实践表明,改革后的课程教学激发了学生的学习兴趣,提高了自主学习能力,促进了师生互动,取得了较好的教学效果。     

医学微生物学实验技术教学体系的建设与实践

《医学微生物学及实验技术》是医学实验技术专业的一门重要专业主干课程,该课程的实验技术部分是学生必须掌握的基本技能。经过数年的教学实践,本着培养应用型人才的目标和重实践教学的教学理念,引入企业实践教学,逐步形成了"医学微生物学实验技术"教学体系,由基础性实验、综合性实验、企业实践三部分组成,并初步建立和实施了形成性考核评价体系。教学实践表明,学生较为全面地掌握了医学微生物学实验技术,对全面提高学生的实验实践能力和综合素质有所助益,有效提高了医学微生物学实验技术教学效果。     

微生物学课程教学考核方式初探与实践

阐述了微生物学课堂教学中知识竞赛这种新型的考核方式在教学实践中的教学实施与教学效果。这种考核方式的实施,促使学生变被动学习为主动学习;加强了学生检索与整理文献的能力;培养了学生团队交流与合作意识;激发创新思维的科学态度与科研理念。知识竞赛这种新型的考核方式取得了较为理想的教学效果。     

“三位一体”育人理念在微生物学实验教学中的探索与实践

微生物学实验是生物工程、制药工程、食品科学与工程、合成生物学等专业的专业基础课和核心实践课。基于价值塑造、知识传授、能力培养的“三位一体”育人理念,教学团队科学制定微生物学实验教学目标,从知识、能力、价值三个维度精心设计教学内容;与时俱进地改进教学内容和教学方法,探索线上线下融合教学,强化实验方法规范性,科教融合培育学生创新思维和科研热情;完善评价体系,建立知识、能力、价值的综合考核方案,创建具有专业特色的微生物学实验室文化。初步建立了微生物学实验“三位一体”教学模式,服务全方位高质量的人才培养使命。     

模块化微生物学实验课教学体系的探索与实践

模块化微生物学实验教学可提高本科生的探究能力和实验技能综合运用能力。本文介绍了我校模块化微生物学实验课教学体系的探索与实践。首先,构建综合性、研究型模块化教学内容体系。教学内容体系由“环境微生物多样性调查”、“功能微生物的筛选鉴定、培养条件优化与选育”和“水质微生物学检验”3个模块共计12个单元实验组成。模块实验内容设计把握3个原则：重视学生基本实验技能培训与探究性学习引导;加强单元实验间的内容衔接,保证模块实验的连贯性;注重内容精炼,步骤简化,充分考虑学生的学习负荷。其次,实行教学研讨会制度,组织教师总结上周实验的得失,讨论和优化本周的实验内容和步骤,建设与模块化微生物实验课教学体系相适应的高水平教学队伍。最后,建立与模块化微生物学实验课教学体系相匹配的多样化考核方式,包括每个单元实验的通过性评价,期末进行操作性实验考试,将撰写单元实验报告改为撰写模块实验论文,突出学生的综合能力和思考能力评价,组织优秀实验成果展示活动,实行激励性评价。     

微生物学混合式教学的探索与实践

微生物学作为生命科学相关专业重要的专业基础课程,在其知识体系的构建中具有重要作用。立足内蒙古农业大学微生物学示范课程改革的教学实践,在混合式教学理念的构建、实施过程、评价体系、教学效果及问题与反思进行深入探讨。结果表明,混合式教学可以帮助学生深入学习理论知识和熟练掌握实践技能,有助于促进学生发现、分析与解决问题能力、协作能力、沟通交流能力、自主学习能力及综合创新能力的提升。     

美国教学型大学微生物学教学模式初探

依据笔者深入美国班尼迪克大学课堂学习为基础,结合与微生物学专业教师的交流及合作,并针对学科定位、生源及课程特点,从教学效果、评价体系等方面探讨了“微生物学”课程的教学模式,该教学模式着重强调学生综合素质的培养,注重以启发及兴趣教学法为主,理论教学、实践教学及课外科研活动相互协调。该研究为我国微生物学教学提供一定的参考。     

微生物学教学在知情意行结构中的探索与实践

阐述了认知结构、情感结构、意志结构和行为结构在当代大学生教育的微生物学学科教学中的探索与实践,包括这种体系的发展基础和建立理念,着重强调其在微生物学教学实践中的实施和所反映出的教学效果。具体来说就是用智给予学生知识,全面提高认知基础;用情关怀学生成长,平稳搭建情感桥梁;用爱启迪学生心灵,迅速增强意志动力;用心培养学生能力,充分施展行为表现。在这种"知情意行"结构的渗透下,大学生的素质教育得到了全面提升,使微生物学教学得到学生的充分肯定并取得比较理想的教学效果。     

基于工程教育专业认证产业需求为导向的“环境微生物学”课程项目化教学改革

本课程团队以地方产业需求为导向,结合国家工程教育专业认证的标准,实施了“环境微生物学”课程项目化教学改革,构建了“教、学、育、用”一体化的创新教学模式。课程设计了3个教学项目、17个学习任务,设定了4个课程目标,完善了课程各目标达成的评价方法,建立了多元化的考核评价体系。课程教学方法多样,授课形式多元,同时注重课程的特色教学和思政教育。课程改革后学生学习的主动性、积极性明显增强,课程目标的达成度均高于期望值;期末学生及格率、综合成绩、督导评价、同行评价、学生评价均有明显的提升,课程的项目化教学改革取得良好的成效。     

地方应用型高校“工业微生物学”课程教学改革与实践

工业微生物学是生命科学类专业的核心课程,该课程应用性强。为更好地实现地方高校应用型人才的培养目标,我们教学团队结合当地产业发展特色,从应用型师资培养、教学内容重组、线上线下混合式和社会实践教学模式构建、形成性学习评价体系建立等环节对"工业微生物学"课程教学进行了改革探索。实践表明,改革后的课程教学激发了学生内在的学习动力,有效提升了学生的应用能力和综合素质,取得了较好的教学效果。     

A Unique Protease Cleavage Site Predicted in the Spike Protein of the Novel Pneumonia Coronavirus (2019-nCoV) Potentially Related to Viral Transmissibility

正Dear Editor,In December 2019, a novel human coronavirus caused an epidemic of severe pneumonia(Coronavirus Disease 2019,COVID-19) in Wuhan, Hubei, China(Wu et al. 2020; Zhu et al. 2020). So far, this virus has spread to all areas of China and even to other countries. The epidemic has caused 67,102 confirmed infections with 1526 fatal cases     

Curcuminoids as inhibitors of thioredoxin reductase: A receptor based pharmacophore study with distance mapping of the active site

Curcumin is the yellow pigment of turmeric that interacts irreversibly forming an adduct with thioredoxin reductase (TrxR), an enzyme responsible for redox control of cell and defence against oxidative stress. Docking at both the active sites of TrxR was performed to compare the potency of three naturally occurring curcuminoids, namely curcumin, demethoxy curcumin and bis-demethoxy curcumin. Results show that active sites of TrxR occur at the junction of E and F chains. Volume and area of both cavities is predicted. It has been concluded by distance mapping of the most active conformations that Se atom of catalytic residue SeCYS498, is at a distance of 3.56 from C13 of demethoxy curcumin at the E chain active site, whereas C13 carbon atom forms adduct with Se atom of SeCys 498. We report that at least one methoxy group in curcuminoids is necessary for interation with catalytic residues of thioredoxin. Pharmacophore of both active sites of the TrxR receptor for curcumin and demethoxy curcumin molecules has been drawn and proposed for design and synthesis of most probable potent antiproliferative synthetic drugs.     

Comparative morphology of the carpel in the Liliaceae: Hewardieae, Petrosavieae, and Tricyrteae

The young pistils in the melanthioid tribes, Hewardieae, Petrosavieae and Tricyrteae, are uniformly tricarpellate and syncarpous. They lack raphide idioblasts. All are multiovulate, with bitegmic ovules. The Petrosavieae are marked by the presence of septal glands and incomplete syncarpy. Tepals and stamens adhere to the ovary in the Hewardieae and the Petrosavieae but not in the Tricyrteae. Two vascular bundles occur in the stamens of the Hewartlieae and Tricyrtis latifolia. Ventral bundles in the upper part of the ovary of the Hewardieae are continuous with compound septal bundles and placental bundles in the lower part. Putative ventral bundles occur in the alternate position in the Tricyrteae and putative placental bundles in the opposite. position in the Petrosavieae. The dichtomously branched stigma in each carpel of the Tricyrteae is supplied by a bifurcated dorsal bundle.     

Enterovirus 71 3C proteolytically processes the histone H3 N-terminal tail during infection

Highlights
1. The N-terminal tail of histone H3 is specifically cleaved during EV71 infection.
2. Viral protease 3C is identified as a protease responsible for proteolytically processing the N-terminal H3 tail.
3. Our finding reveals a new epigenetic regulatory mechanism for Enterovirus 71 in virus-host interactions.     

Detection of EBV and HHV6 in the Brain Tissue of Patients with Rasmussen’s Encephalitis

Rasmussen’s encephalitis (RE) is a rare pediatric neurological disorder, and the exact etiology is not clear. Viral infection may be involved in the pathogenesis of RE, but conflicting results have reported. In this study, we evaluated the expression of both Epstein-Barr virus (EBV) and human herpes virus (HHV) 6 antigens in brain sections from 30 patients with RE and 16 control individuals by immunohistochemistry. In the RE group, EBV and HHV6 antigens were detected in 56.7% (17/30) and 50% (15/30) of individuals, respectively. In contrast, no detectable EBV and HHV6 antigen expression was found in brain tissues of the control group. The co-expression of EBV and HHV6 was detected in 20.0% (6/30) of individuals. In particular, a 4-year-old boy had a typical clinical course, including a medical history of viral encephalitis, intractable epilepsy, and hemispheric atrophy. The co-expression of EBV and HHV6 was detected in neurons and astrocytes in the brain tissue, accompanied by a high frequency of CD8⁺ T cells. Our results suggest that EBV and HHV6 infection and the activation of CD8⁺ T cells are involved in the pathogenesis of RE.