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Activation and repression by the C-terminal domain of Dorsal 总被引:6,自引:0,他引:6
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The inhibitory ankyrin and activator Rel proteins. 总被引:31,自引:0,他引:31
The gene families encoding the proteins NF-kappa B, c-Rel and Dorsal, in conjunction with their respective inhibitors l kappa B, pp40, and Cactus, achieve specificity in gene regulation by means of common principles. The related activities of NF-kappa B and Dorsal are mediated by heterodimeric or homodimeric complexes of proteins containing the conserved dimerization and DNA-binding domain termed Rel. The l kappa Bs and Cactus, which share a core series of structural repeats termed ankyrin, inhibit cognate activators through differential interactions with the Rel-homology domain. Together, the inhibitory ankyrin proteins and their cognate Rel dimers probably define specific signalling pathways able to activate specific gene expression. Both gene families include proto-oncogenes, thus broadly implicating Rel/l kappa B in the control of both normal gene expression and the aberrant gene expression that makes cells cancerous. 相似文献
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Function of NF-kappa B/Rel binding sites in the major histocompatibility complex class II invariant chain promoter is dependent on cell-specific binding of different NF-kappa B/Rel subunits. 下载免费PDF全文
A M Brown M W Linhoff B Stein K L Wright A S Baldwin Jr P V Basta J P Ting 《Molecular and cellular biology》1994,14(5):2926-2935
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DNA-bound Fos proteins activate transcription in yeast 总被引:59,自引:0,他引:59
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Oncogenic transformation by vrel requires an amino-terminal activation domain. 总被引:44,自引:22,他引:22 下载免费PDF全文
J Kamens P Richardson G Mosialos R Brent T Gilmore 《Molecular and cellular biology》1990,10(6):2840-2847