共查询到19条相似文献，搜索用时 46 毫秒
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立德树人是教育事业的根本任务,课程思政是将立德树人融入教育各环节、各领域的重要手段。"细胞生物学"既是现代生命科学的前沿分支学科之一,也是高校生命科学类专业的重要课程。该文在课程思政的背景下,选择新型冠状病毒肺炎疫情(简称:新冠疫情)为载体,以"细胞生物学"课程中"病毒的特征、入侵、增殖"为主线,从"教学内容的甄选"和"实施策略"两个方面着手,开展聚焦新冠疫情下"细胞生物学"课程思政教学的深入探讨。该研究旨在引导学生在研习专业知识的基础上,提升其科学素养、树立其正确的价值观,为侧重新冠疫情的课程思政研究提供重要参考。 相似文献
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目的探讨肺炎链球菌与呼吸道合胞病毒（RSV）共感染对肺炎患儿外周血免疫细胞变化的影响及其与疾病预后之间的关系。方法选取2022年6月至2024年2月在我院治疗的88例肺炎患儿为研究对象,患儿分为单纯肺炎链球菌感染组（32例）、单纯RSV感染组（28例）及共感染组（28例）。检测患儿外周血中T细胞、B细胞、NK细胞、中性粒细胞及单核巨噬细胞的数量,并分析这些免疫细胞与住院时间、并发症发生率及抗生素应用时长等预后指标的相关性。结果与2个单纯感染组相比,共感染组患儿的T细胞（t=1.225,P=0.032）、B细胞（t=2.213,P＜0.001）、NK细胞（t=3.205,P＜0.001）、中性粒细胞（t=3.021,P＜0.0001）和单核巨噬细胞（t=1.005,P=0.012）数量显著增高,其中中性粒细胞的增加最为显著。共感染组患儿的住院时间与T细胞（r=−0.515,P=0.001）和NK细胞（r=−0.467,P=0.001）呈负相关,与中性粒细胞（r=0.625,P=0.001）和单核巨噬细胞（r=0.625,P=0.024）呈正相关;并发症发生率与T细胞（r=−0.405,P=0.032）、NK细胞（r=−0.467,P=0.024）呈负相关,与中性粒细胞（r=0.425,P=0.011）和单核巨噬细胞（r=0.535,P=0.027）呈正相关;抗生素应用时长与T细胞（r=−0.515,P＜0.001）和NK细胞（r=−0.467,P＜0.001）呈负相关,与中性粒细胞（r=0.725,P＜0.001）和单核巨噬细胞（r=0.755,P=0.024）呈正相关。结论肺炎链球菌与RSV共感染会显著影响儿童肺炎患者的免疫细胞数量,且这些变化与预后密切相关。T细胞和NK细胞数量的增加与较好的预后相关,而中性粒细胞和单核巨噬细胞的增加则与较差的预后相关,提示调节免疫细胞功能可能是改善共感染患儿预后的重要策略。 相似文献
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本研究旨在评估大连医科大学医学微生物学课程线上教学效果,及时发现和总结线上教学中存在的问题,为教学课程改革提供依据。使用大连医科大学网络题库与考试评价系统对2021年参加医学微生物学课程线上学习和考试的641名学生的试卷进行分析,分析内容包括试卷各章节的正确率、难度系数、信度和区分度。结果显示,本次考试成绩呈正态分布,各章节正确率为70%～90%,考试平均分72.28,及格率85%,优秀率4%。试卷总体质量良好,难度略偏易,难度系数0.72。信度和区分度好,区分度0.29,信度为0.9。2021年线上教学与2019年线下教学的学生期末试卷成绩相比无显著性差异(P>0.05)。本研究证实本次线上考试试卷总体质量良好,能够客观体现教学质量和学生学业水平,线上教学效果基本满意。本研究还比较了试卷中各题型的难度系数和区分度,为今后制定科学合理的线上考核试卷提供依据和参考。 相似文献
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本研究的目的是为提高COVID-19患者重症病例的治愈率,降低病亡率,提供理论基础和临床实践.本研究收集了典型的COVID-19重症病例患者病例,系统的分析了重症病例的临床表现、病理特性和诊疗技术,结合典型的重症病例,借鉴中国国家卫健委发布的《新型冠状病毒肺炎诊疗方案》,提出了一套诊断和治疗重型新型冠状病毒肺炎的方法,... 相似文献
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Jiamnin Liu Fan Lu Yinghua Chen Edward Plow Jun Qin 《The Journal of biological chemistry》2022,298(3)
Coronavirus disease 2019 (COVID-19) is a highly contagious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is broadly accepted that SARS-CoV-2 utilizes its spike protein to recognize the extracellular domain of angiotensin-converting enzyme 2 (ACE2) to enter cells for viral infection. However, other mechanisms of SARS-CoV-2 cell entry may occur. We show quantitatively that the SARS-CoV-2 spike protein also binds to the extracellular domain of broadly expressed integrin α5β1 with an affinity comparable to that of SARS-CoV-2 binding to ACE2. More importantly, we provide direct evidence that such binding promotes the internalization of SARS-CoV-2 into non-ACE2 cells in a manner critically dependent upon the activation of the integrin. Our data demonstrate an alternative pathway for the cell entry of SARS-CoV-2, suggesting that upon initial ACE2-mediated invasion of the virus in the respiratory system, which is known to trigger an immune response and secretion of cytokines to activate integrin, the integrin-mediated cell invasion of SARS-CoV-2 into the respiratory system and other organs becomes effective, thereby promoting further infection and progression of COVID-19. 相似文献
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Revisiting Metchnikoff''s work in light of the COVID-19 pandemic illustrates how much this amazing scientist was a polymath, and one could speculate how much he would have been fascinated and most interested in following the course of the pandemic. Since he coined the word “gerontology”, he would have been intrigued by the high mortality among the elderly, and by the concepts of immunosenescence and inflammaging that characterize the SARS-CoV-2 infection. While Metchnikoff''s work is mainly associated with the discovery of the phagocytes and the birth of cellular innate immunity, he regularly invited his closest collaborators to investigate humoral immunity, and it was in his laboratory that Jules Bordet made his major discovery of the complement system. While Metchnikoff and his team investigated many infectious diseases, he also contributed to studies linked to vaccination, such as those on typhoid fever performed in chimpanzees, illustrating that non-human primates can provide animal models which are potentially helpful for understanding the pathophysiology of the COVID-19 virus. In the present review, we illustrate how much his own work and the investigations of his trainees were pertinent to this new disease. 相似文献
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Matheus S Gasparini Leandro M dos Santos Ahmad MA Hamade Luísa G Gross Arthur P Favarato Jos PC de Vasconcellos Mnica B de Melo Pierina L Parise Camila L Simeoni Natlia B Silva Marcelo A da Silva Mori Andr S Vieira Alessandro dos Santos Farias Fabiana Granja Angelica Z Schreiber Maria L Moretti Jos L Proena-Modena Mnica Alves 《Experimental biology and medicine (Maywood, N.J.)》2021,246(23):2495
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目的 新型冠状病毒（SARS-CoV-2）变体往往具有更强的感染力与免疫逃逸能力,目前出现的SARS-CoV-2变体种类繁多,疫情评估与防控形势严峻。本文希望通过建立模拟病毒传染的理论模型,对SARS-CoV-2及其变体引起的疫情进行追踪与预测,并对它们的综合传染性进行评估。方法 根据方格传染病模型,对传染持续时间和群体免疫作用的相互关系进行推导,并在此基础上建立了新型冠状病毒肺炎（COVID-19）疫情感染传播的普遍理论模型,提出感染力参数A和免疫作用参数B,将传染时间与感染人数的复杂关系公式化,用于预测感染日变曲线。还引入了突变株综合传染性参数
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建立一种高通量的基因微阵列检测技术,对常见呼吸道病毒感染进行监控.根据公开发表的8个病毒科38种常见呼吸道病毒的序列,计算其保守区域,设计病毒的特异性检测探针,制备呼吸道病毒检测基因微阵列.利用随机引物PCR方法标记样品中的病毒靶序列,标记产物与基因微阵列上的探针杂交,清洗、扫描后进行结果分析.采用流感病毒、麻疹病毒、腮腺炎病毒和风疹病毒作为报告病毒,并对80例上呼吸道感染患者的咽拭子标本进行验证测试.初步结果表明,该呼吸道病毒微阵列基因芯片检测是可行的,在利用基因微阵列技术对病毒监控方面进行了有益的尝试,得到了有经验的信息. 相似文献
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《Microbes and infection / Institut Pasteur》2022,24(1):104911
Considering common childhood respiratory viruses and SARS-CoV-2 share similar transmission routes, non-pharmaceutical interventions (NPIs) to prevent SARS-CoV-2 may affect the epidemiology of respiratory viruses. Therefore, our study aimed to observe the epidemiologic characteristics of common childhood respiratory viruses in 2020 (after the pandemic) compared with 2019 (before the pandemic) in Hangzhou, China. The data were compared between 2019 and 2020 based on age and month, respectively. One or more viruses were detected in 3135/21452 (14.61%) specimens in 2019, which was significantly lower in 1110/8202 (13.53%) specimens in 2020. Respiratory syncytial virus (RSV) was the most commonly detected virus in 2019 and 2020. The positive rate of adenovirus (ADV), parainfluenza virus (PIV)1, PIV2, and PIV3 in 2020 was significantly decreased in 2019. In 2020, RSV replaced ADV as the most predominant virus in children aged 1–6 years, and the positive rate of influenza virus A (FluA), influenza virus B (FluB), PIV1, and PIV2 was not correlated to age. FluA, FluB, and PIV2 were not almost detected from February 2020. The positive rates of ADV and PIV1 were uncorrelated to the month in 2020. By strict NPIs, besides controlling the COVID-19 pandemic, incredible progress has been made to reduce the prevalence of common childhood respiratory viruses. 相似文献
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Zheng Chen Bili Wang Shanshan Mao Qing Ye 《International journal of biological sciences》2021,17(4):1119
With ongoing research, it was found that asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was widespread in coronavirus disease 2019 (COVID-19) populations. Studies have confirmed asymptomatic patients with COVID-19 have potential infectivity, and most of the transmission occurred before symptoms appear. Asymptomatic infection rates varied widely in different countries and regions. Identifying the asymptomatic infected persons and cutting off the infection source is an effective way to prevent the spread of this disease. However, asymptomatic patients have hidden clinical symptoms, and screening based only on the clinical symptoms of COVID-19 can easily lead to a missed diagnosis. Therefore, determining asymptomatic infection patients by SARS-CoV-2 nucleic acid testing is the gold standard. A series of prevention and control measures adopted by the Chinese government, especially the “Four Early” policy, have achieved outstanding achievements, which are worth learning from by other countries. 相似文献
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《Cell reports》2023,42(4):112282
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