共查询到20条相似文献,搜索用时 31 毫秒
1.
2.
Vandepoele K Vlieghe K Florquin K Hennig L Beemster GT Gruissem W Van de Peer Y Inzé D De Veylder L 《Plant physiology》2005,139(1):316-328
3.
4.
5.
6.
7.
8.
9.
10.
Defective gene expression,S phase progression,and maturation during hematopoiesis in E2F1/E2F2 mutant mice 总被引:6,自引:0,他引:6 下载免费PDF全文
E2F plays critical roles in cell cycle progression by regulating the expression of genes involved in nucleotide synthesis, DNA replication, and cell cycle control. We show that the combined loss of E2F1 and E2F2 in mice leads to profound cell-autonomous defects in the hematopoietic development of multiple cell lineages. E2F2 mutant mice show erythroid maturation defects that are comparable with those observed in patients with megaloblastic anemia. Importantly, hematopoietic defects observed in E2F1/E2F2 double-knockout (DKO) mice appear to result from impeded S phase progression in hematopoietic progenitor cells. During DKO B-cell maturation, differentiation beyond the large pre-BII-cell stage is defective, presumably due to failed cell cycle exit, and the cells undergo apoptosis. However, apoptosis appears to be the consequence of failed maturation, not the cause. Despite the accumulation of hematopoietic progenitor cells in S phase, the combined loss of E2F1 and E2F2 results in significantly decreased expression and activities of several E2F target genes including cyclin A2. Our results indicate specific roles for E2F1 and E2F2 in the induction of E2F target genes, which contribute to efficient expansion and maturation of hematopoietic progenitor cells. Thus, E2F1 and E2F2 play essential and redundant roles in the proper coordination of cell cycle progression with differentiation which is necessary for efficient hematopoiesis. 相似文献
11.
12.
Gene expression changes in response to E2F1 activation 总被引:9,自引:1,他引:8
13.
14.
15.
T. L. Sladek 《Cell proliferation》1997,30(3):97-105
16.
Marzio G Wagener C Gutierrez MI Cartwright P Helin K Giacca M 《The Journal of biological chemistry》2000,275(15):10887-10892
17.
18.
19.