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Tsui K Dubuis S Gebbia M Morse RH Barkai N Tirosh I Nislow C 《Molecular and cellular biology》2011,31(21):4348-4355
To examine the role of nucleosome occupancy in the evolution of gene expression, we measured the genome-wide nucleosome profiles of four yeast species, three belonging to the Saccharomyces sensu stricto lineage and the more distantly related Candida glabrata. Nucleosomes and associated promoter elements at C. glabrata genes are typically shifted upstream by ~20 bp, compared to their orthologs from sensu stricto species. Nonetheless, all species display the same global organization features first described for Saccharomyces cerevisiae: a stereotypical nucleosome organization along genes and a division of promoters into those that contain or lack a pronounced nucleosome-depleted region (NDR), with the latter displaying a more dynamic pattern of gene expression. Despite this global similarity, however, nucleosome occupancy at specific genes diverged extensively between sensu stricto and C. glabrata orthologs (~50 million years). Orthologs with dynamic expression patterns tend to maintain their lack of NDR, but apart from that, sensu stricto and C. glabrata orthologs are nearly as similar in nucleosome occupancy patterns as nonorthologous genes. This extensive divergence in nucleosome occupancy contrasts with a conserved pattern of gene expression. Thus, while some evolutionary changes in nucleosome occupancy contribute to gene expression divergence, nucleosome occupancy often diverges extensively with apparently little impact on gene expression. 相似文献
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Nucleosome eviction from MHC class II promoters controls positioning of the transcription start site 下载免费PDF全文
Elisa Leimgruber Queralt Seguín-Estévez Isabelle Dunand-Sauthier Natalia Rybtsova Christoph D. Schmid Giovanna Ambrosini Philipp Bucher Walter Reith 《Nucleic acids research》2009,37(8):2514-2528
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Regulating retrotransposon activity through the use of alternative transcription start sites 下载免费PDF全文
Jenna Persson Babett Steglich Agata Smialowska Mette Boyd Jette Bornholdt Robin Andersson Catherine Schurra Benoit Arcangioli Albin Sandelin Olaf Nielsen Karl Ekwall 《EMBO reports》2016,17(5):753-768