Computational Biology of Olfactory Receptors

Olfactory receptors, in addition to being involved in first step of the physiological processes that leads to olfaction, occupy an important place in mammalian genomes. ORs constitute super families in these genomes. Elucidating ol-factory receptor function at a molecular level can be aided by a computationally derived structure and an understanding of its interactions with odor molecules. Experimental functional analyses of olfactory receptors in conjunction with computational studies serve to validate findings and generate hypotheses. We present here a review of the research efforts in: creating computational models of olfactory receptors, identifying binding strategies for these receptors with odorant molecules, performing medium to long range simulation studies of odor ligands in the receptor binding region, and identifying amino acid positions within the receptor that are responsible for ligand-binding and olfactory receptor activation. Written as a primer and a teaching tool, this review will help researchers extend the methodologies described herein to other GPCRs.     

Computational Molecular Biology(CMB)

正Computational Molecular Biology(ISSN 1927-5587)is an open access,peer reviewed journal published online by Bio Publisher.The Journal is publishing all the latest and outstanding research articles,letters,methods,and reviews in all areas of Computational Molecular Biology,covering new discoveries in molecular biology,from genes to genomes,using statistical,mathematical,and computational methods as well as new     

Ranked retrieval of Computational Biology models

Background  

The study of biological systems demands computational support. If targeting a biological problem, the reuse of existing computational models can save time and effort. Deciding for potentially suitable models, however, becomes more challenging with the increasing number of computational models available, and even more when considering the models' growing complexity. Firstly, among a set of potential model candidates it is difficult to decide for the model that best suits ones needs. Secondly, it is hard to grasp the nature of an unknown model listed in a search result set, and to judge how well it fits for the particular problem one has in mind.     

Computational Molecular Biology(CMB)

<正>Computational Molecular Biology(ISSN 1927-5587)is an open access,peer reviewed journal published online by BioP ublisher.The Journal is publishing all the latest and outstanding research articles,letters,methods,and reviews in all areas of Computational Molecular Biology,covering new discoveries in molecular biology,from genes to genomes,using statistical,mathematical,and computational methods as well as new development of     

Computational Molecular Biology(CMB)

<正>Computational Molecular Biology(ISSN 1927-5587)is an open access,peer reviewed journal published online by BioP ublisher.The Journal is publishing all the latest and outstanding research articles,letters,methods,and reviews in all areas of Computational Molecular Biology,covering new discoveries in molecular biology,from genes to genomes,using statistical,mathematical,and computational methods as well as new development of     

Computational Molecular Biology(CMB)

正Computational Molecular Biology(ISSN 1927-5587)is an open access,peer reviewed journal published online by Bio Publisher.The Journal is publishing all the latest and outstanding research articles,letters,methods,and reviews in all areas of Computational Molecular Biology,covering new discoveries in molecular biology,from genes to     

Computational Molecular Biology(CMB)

正Computational Molecular Biology(ISSN 1927-5587)is an open access,peer reviewed journal published online by Bio Publisher.The Journal is publishing all the latest and outstanding research articles,letters,methods,and reviews in all areas of Computational Molecular Biology,covering new discoveries in molecular biology,from genes to genomes,using statistical,mathematical,and computational methods as well as new     

Computational Molecular Biology(CMB)

正Computational Molecular Biology(ISSN 1927-5587)is an open access,peer reviewed journal published online by Bio Publisher.The Journal is publishing all the latest and outstanding research articles,letters,methods,and reviews in all areas of Computational Molecular Biology,covering new discoveries in molecular biology,from genes to     

Computational Molecular Biology(CMB)

正Computational Molecular Biology(ISSN 1927-5587)is an open access,peer reviewed journal published online by Bio Publisher.The Journal is publishing all the latest and outstanding research articles,letters,methods,and reviews in all areas of Computational Molecular Biology,covering new discoveries in molecular biology,from genes to