An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma

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MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity

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Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription

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CRTC1/MAML2 directs a PGC-1α-IGF-1 circuit that confers vulnerability to PPARγ inhibition

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PROX1 induction by autolysosomal activity stabilizes persister-like state of colon cancer via feedback repression of the NOX1-mTORC1 pathway

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The Aspartic Protease Ddi1 Contributes to DNA-Protein Crosslink Repair in Yeast

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ICAM-1-mediated adhesion is a prerequisite for exosome-induced T cell suppression

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DSB repair pathway choice is regulated by recruitment of 53BP1 through cell cycle-dependent regulation of Sp1

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Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex

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SREBP-1c impairs ULK1 sulfhydration-mediated autophagic flux to promote hepatic steatosis in high-fat-diet-fed mice

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The Arabidopsis mature endosperm promotes seedling cuticle formation via release of sulfated peptides

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Visualization of Ligand-Bound Ectodomain Assembly in the Full-Length Human IGF-1 Receptor by Cryo-EM Single-Particle Analysis

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Single-cell RNA sequencing identifies a population of human liver-type ILC1s

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MMB-FOXM1-driven premature mitosis is required for CHK1 inhibitor sensitivity

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NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis

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Tim4 recognizes carbon nanotubes and mediates phagocytosis leading to granuloma formation

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Unconventional initiation of PINK1/Parkin mitophagy by Optineurin

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Recognition of HIV-1 capsid by PQBP1 licenses an innate immune sensing of nascent HIV-1 DNA

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PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate

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A non-canonical target-binding site in Munc18-1 domain 3b for assembling the Mint1-Munc18-1-syntaxin-1 complex

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