新疆北部碳酸盐岩中一个晚泥盆世法门期放射虫动物群

产于新疆北部乌图布拉克（和丰牧场）俄姆哈一带根那仁组（上泥盆统上部—下石炭统下部）硅化灰岩中的这个放射虫动物群包括１２属１９种和２未定种,其中有新属１个,新种７个。这个动物群有二个形态组合,一个以球形多囊虫类Ｅｎｔａｅｔｉｎｉｄａｅ科占优势,另一个以Ｃｅｒａｔｏｉｋｉｓｃｉｄａｅ科和Ｈｏｌｏｅｃｉｓｃｉｄａｅ科的成员为特征。这个动物群与北美西部、俄罗斯东北部晚泥盆世法门期放射虫动物群可以对比,并可归入Ｈｏｌｏｅｃｉｓｃｕｓｆｏｒｅｍａｎａｅ带。     

二叠纪放射虫Follicucullus bipartitus－F．charveti组合带的发现及其地质意义

二叠纪丑中虫科放射虫中有一类顶锥部分向腹边弯曲的放射虫,Ｉｓｈｉｇａ称为Ｆｏｌｌｉｃｕｃｕｌｌｕｓｂｉｐａｒｔｉｔｕｓ－Ｆ．ｃｈａｒｖｅｔｉ组合带,由于其形状奇特,层位稳定,已成为二叠纪较好的标准带化石,并与类Ｌｅｐｉｄｏｌｉｎａｋｕｍａｅｎｓｉｓ带对比。目前这类化石仅在东南亚地区的西南日本、菲律宾巴拉望地区和中国广西钦州地区发现表明,这些地区的放射虫当时很可能是在同一个洋盆中沉积的,只是由于它们各自的沉积历史不一样,以及后来的板块活动,造成了原始块体的离散、飘移,形成目前这种分布格局。这个放射虫动物群包括６科１１属２１种（比较种、未定种）,其中有新种１个。这个动物群的时代要早于晚二叠世。     

滇西早石炭世放射虫化石

本文记述了采自滇西孟连、耿马及德钦地区的放射虫化石,共计１３属２５种（亚种）和６未定种,其中１新种（Ｐｏｌｙｅｎｔａｃｔｉｎｉａｓｅｘａｎｇｕｌａｔａｓｐ．ｎｏｖ．）和１新亚种（Ａｌｂａｉｌｅｌａｉｎｄｅｎｓｉｓｂｒａｕｎｉｓｕｂｓｐ．ｎｏｖ．）。该动物群可以与西欧早石炭世放射虫动物群对比。它们被划分为５个组合带,其中Ａｌｂａｉｌｅｌａｃｆ．ｐａｒａｄｏｘａ,Ａｌｂａｉｌｅｌａｄｅｆｌａｎｄｒｅｉ,Ａｌｂａｉｌｅｌａｉｎｄｅｎｓｉｓ和Ｅｏｓｔｙｌｏｄｉｃｔｙａｒｏｔａ组合带可与Ｂｒａｕｎ等（１９９３）的同名化石带对比,Ａｌｂａｉｌｅｌａｃａｒｔａｌａ组合带大致相当于Ｂｒａｕｎ等（１９９３）的Ａｌｂａｉｌｅｌａｃａｒｔａｌａ和Ｌａｔｅｎｔｉｆｉｓｔｕｌａｃｏｎｃｅｎｔｒｉｃａ带。     

四川盆地第四纪哺乳动物群的演替

在新发现的北碚天台山、华蓥天池、合川三汇坝等哺乳动物化石群研究的基础上,综合四川盆地及盆周山地１５个化石群的资料,应用动物生存时代几率、断代动物、动物绝灭率的分析和年代学数据的比较等方法,判断了各动物群的时代,划分出四川盆地第四纪哺乳动物群的５个演化阶段（３个动物群含４个亚群）：早更新世的Ａｉｌｕｒｏｐｏｄａｍｉｃｒｏｔａ动物群;中晚更新世的ＲｈｉｎｏｃｅｒｏｓｓｉｎｅｎｓｉｓＭｅｇａｔａｐｉｒｕｓａｕｇｕｓｔｕｓ动物群,包括Ａ．ｍｄａｎｏｌｅｕｃａｆｏｖｅａｌｉｓＨｙａｅｎａｓｉｎｅｎｓｉｓ亚群（Ｑ２）和Ａ．ｍ．ｂａｃｏｎｉＣｒｏｃｕｔａｕｌｔｉｍａ亚群（Ｑ３）;全新世的Ａ．ｍ．ｍｅｌａｎｏｌｅｕｃａＤｏｍｅｓｔｉｃ动物群,包括Ｒ．ｓｏｎｄａｉｃｕｓＳｕｓｄｏｍｅｓｔｉｃａ亚群（Ｑ４中后期）和田野城镇（ＦｉｅｌｄＴｏｗｎ）亚群     

湘中锡矿山邵东组和孟公坳组孢子组合──兼论泥盆－石炭系界线

湘中锡矿山邵东组和孟公坳组共产小孢子４５属８３种（含１０个新种,３个新联合）,可划分为４个孢子组合,即：Ｒｅｔｉｓｐｏｒａｌｅｐｉｄｏｐｈｙｔａ－Ａｐｉｃｕｌｉｒｅｔｕｓｉｓｐｏｒａｆｒｕｃｔｉｃｏｓａ（ＬＦ）组合,Ｒｕｇｏｓｐｏｒａｃｆ．ｆｌｅｘｕｏｓａ－Ｒｅｔｉｓｐｏｒａｌｅｐｉｄｏｐｈｙｔａ（ＦＬ）组合,ＬｏｐｈｏｚｏｎｏｔｒｉＩｅｔｅｓｅｘｃｉｓｕｓ－Ｒｅｔｉｓｐｏｒａｌｅｐｉｄｏｐｈｙｔａ（ＥＬ）组合和Ｃｒａｓｓｉｓｐｏｒａｃｆ．ｋｏｓａｎｋｅｉ－Ｌｙｃｏｓｐｏｒａｄｅｎｔｉｃｕｌａｔａ（ＫＤ）组合。根据孢子组合的特征,泥盆－石炭系界线置于ＥＬ与ＫＤ组合之间,即相当于孟公坳组中下部与上部之间。     

微量元素锗对四种微藻光合色素的影响

采用溶液培养方法,以锗作为胁迫因子,研究了锗对４种微藻“钝顶螺旋藻（Ｓｐｉｒｕｌｉｎａ ｐｌａｔｅｎｓｉｓ）、盐生杜氏藻（Ｄｕｎａｌｉｅｌｌａ ｓａｌｉｎａ）、淇江叉鞭金藻（Ｄｉｃｒａｔｅｒｉａ ｚｈａｎｊｉａｎｇｅｎｓｉｓ）和微绿藻（Ｎａｎｎｏｃｈｌｏｒｏｐｓｉｓ．ｓｐ）光合色素的影响。实验结果表明,经１０ｍｇ／ｄｍ＾３锗处理后,四种藻类细胞中的光合色素都发生了较大变化,有些色素发生明显的增加或     

人埃里希体的研究进展

人埃里希体包括３个种：Ｅｈｒｌｉｃｈｉａ ｓｅｎｎｅｔｓｕ、Ｅｈｒｌｉｃｈｉａ ｃｈａｆｆｅｅｎｉｓｉｓ和人粒细胞埃里希体（ＨＧＥ）。Ｅ．ｓｅｎｎｅｔｓｕ和Ｅ．ｃｈａｆｆｅｅｎｓｉｓ主要寄生在单核细胞和巨噬细胞内,而ＨＧＥ主要寄生在粒细胞内。ＨＧＥ和Ｅ．ｃｈａｆｆｅｅｎｓｉｓ的传播媒介是蜱。３种人埃里希体分属埃里希体属３个不同的１６Ｓ ｒＲＮＡ基因群。     

c-fos基因在内皮素-1促肺泡Ⅱ型细胞表面活性物质合成中的作用

应用反义技术探讨ｃ－ｆｏｓ基因ＥＴ－１调控肺泡Ⅱ型细胞（ＡＴⅡ）表面活性物质（ＰＳ）合成的胞内信号转导中的作用,结果显示：（１）内皮素－１（ＥＴ－１）可提高ＡＴⅡ细胞的＾３Ｈ－胆碱掺入。（２）蛋白激酶Ｃ（ＰＫＣ）激活剂ＰＭＡ可使ＡＴⅡ细胞的＾３Ｈ－胆碱掺入量增加,ＰＫＣ抑制剂Ｈ７可抑制ＥＴ－１的促ＰＳ合成效应。（３）ＥＴ－１和ＰＭＡ可显著提高Ｆｏｓ蛋白表达量,Ｈ７和ｃ－ｆｏｓ反义寡核苷酸（ＯＤＮ）     

海南岛东部近海新第三纪孢粉植物群

根据ＢＤ２３－１－１井与孢子花粉共生的海相浮游有孔虫和钙质超微化石,论述了中国海南岛东部近海新第三纪各个时期的孢粉植物群特征。建立了４个孢粉组合,它们是：１．Ｑｕｅｒｃｏｉｄｉｔｅｓ－Ｃｕｐｕｌｉｆｅｒｏｉｐｏｌｅｎｉｔｅｓ－Ｆｌｏｒｓｈｕｅｔｚｉａ－Ｄｉｃｏｌｐｏｐｏｌｉｓ组合（早中新世晚期）;２．Ｄｉｃｏｌｐｏｐｏｌｉｓ－Ｅｘｔｒａ－ｐｕｎｃｔａｔｏｓｐｏｒｉｔｅｓ－Ｔａｘｏｄｉａｃｅａｅｐｏｌｅｎｉｔｅｓ组合（中中新世早期）;３．Ａｂｉｅｔｉｎｅａｅｐｏｌｅｎｉｔｅｓ－Ｐｏｌｙｐｏｄｉ－ａｃｅａｅｓｐｏｒｉｔｅｓ－Ｌｉｑｕｉｄａｍｂａｒｐｏｌｅｎｉｔｅｓ组合（中中新世晚期至晚中新世）;４．Ａｂｉｅｔｉｎｅａｅｐｏｌｅｎｉｔｅｓ－Ｐｅｒｓｉｃａｒｉｏｉｐｏｌｉｓ组合（晚中新世晚期至早上新世）。孢粉植物群反映了海南岛东部近海新第三纪的气候基本上一直比较温暖湿润,并且逐渐降温的历程。     

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ＫＥＹＷＯＲＤＩＮＤＥＳ（１９９６，Ｖｏｌ．１７）Ａｂｕｎｄａｎｃｅ（３）：２３２ＡＣＡｓｅｒｕｍ（４）：４９９，５０７Ａｃｃｉｐｉｔｒｉｄａｅ（４）＝４８２Ａｄｅｎｏｈｙｐｏｐｈｙｓｉｓ（ｌ）：７８Ａｅｒｉａｌｒｅｓｐｉｒａｔｉｏｎ（２）：１５１Ａ...     

A Unique Protease Cleavage Site Predicted in the Spike Protein of the Novel Pneumonia Coronavirus (2019-nCoV) Potentially Related to Viral Transmissibility

正Dear Editor,In December 2019, a novel human coronavirus caused an epidemic of severe pneumonia(Coronavirus Disease 2019,COVID-19) in Wuhan, Hubei, China(Wu et al. 2020; Zhu et al. 2020). So far, this virus has spread to all areas of China and even to other countries. The epidemic has caused 67,102 confirmed infections with 1526 fatal cases     

Curcuminoids as inhibitors of thioredoxin reductase: A receptor based pharmacophore study with distance mapping of the active site

Curcumin is the yellow pigment of turmeric that interacts irreversibly forming an adduct with thioredoxin reductase (TrxR), an enzyme responsible for redox control of cell and defence against oxidative stress. Docking at both the active sites of TrxR was performed to compare the potency of three naturally occurring curcuminoids, namely curcumin, demethoxy curcumin and bis-demethoxy curcumin. Results show that active sites of TrxR occur at the junction of E and F chains. Volume and area of both cavities is predicted. It has been concluded by distance mapping of the most active conformations that Se atom of catalytic residue SeCYS498, is at a distance of 3.56 from C13 of demethoxy curcumin at the E chain active site, whereas C13 carbon atom forms adduct with Se atom of SeCys 498. We report that at least one methoxy group in curcuminoids is necessary for interation with catalytic residues of thioredoxin. Pharmacophore of both active sites of the TrxR receptor for curcumin and demethoxy curcumin molecules has been drawn and proposed for design and synthesis of most probable potent antiproliferative synthetic drugs.     

Comparative morphology of the carpel in the Liliaceae: Hewardieae, Petrosavieae, and Tricyrteae

The young pistils in the melanthioid tribes, Hewardieae, Petrosavieae and Tricyrteae, are uniformly tricarpellate and syncarpous. They lack raphide idioblasts. All are multiovulate, with bitegmic ovules. The Petrosavieae are marked by the presence of septal glands and incomplete syncarpy. Tepals and stamens adhere to the ovary in the Hewardieae and the Petrosavieae but not in the Tricyrteae. Two vascular bundles occur in the stamens of the Hewartlieae and Tricyrtis latifolia. Ventral bundles in the upper part of the ovary of the Hewardieae are continuous with compound septal bundles and placental bundles in the lower part. Putative ventral bundles occur in the alternate position in the Tricyrteae and putative placental bundles in the opposite. position in the Petrosavieae. The dichtomously branched stigma in each carpel of the Tricyrteae is supplied by a bifurcated dorsal bundle.     

Enterovirus 71 3C proteolytically processes the histone H3 N-terminal tail during infection

Highlights
1. The N-terminal tail of histone H3 is specifically cleaved during EV71 infection.
2. Viral protease 3C is identified as a protease responsible for proteolytically processing the N-terminal H3 tail.
3. Our finding reveals a new epigenetic regulatory mechanism for Enterovirus 71 in virus-host interactions.     

Detection of EBV and HHV6 in the Brain Tissue of Patients with Rasmussen’s Encephalitis

Rasmussen’s encephalitis (RE) is a rare pediatric neurological disorder, and the exact etiology is not clear. Viral infection may be involved in the pathogenesis of RE, but conflicting results have reported. In this study, we evaluated the expression of both Epstein-Barr virus (EBV) and human herpes virus (HHV) 6 antigens in brain sections from 30 patients with RE and 16 control individuals by immunohistochemistry. In the RE group, EBV and HHV6 antigens were detected in 56.7% (17/30) and 50% (15/30) of individuals, respectively. In contrast, no detectable EBV and HHV6 antigen expression was found in brain tissues of the control group. The co-expression of EBV and HHV6 was detected in 20.0% (6/30) of individuals. In particular, a 4-year-old boy had a typical clinical course, including a medical history of viral encephalitis, intractable epilepsy, and hemispheric atrophy. The co-expression of EBV and HHV6 was detected in neurons and astrocytes in the brain tissue, accompanied by a high frequency of CD8⁺ T cells. Our results suggest that EBV and HHV6 infection and the activation of CD8⁺ T cells are involved in the pathogenesis of RE.     

Perinatal Vertical Transmission of Chikungunya Virus in Ruili,a Town on the Border between China and Myanmar

正Dear Editor,Chikungunya virus (CHIKV), an arbovirus in the family of Togaviridae, genus Alphavirus, is transmitted by the A.aegyptii or A. albopictus mosquito, and causes disease in humans characterized by fever, rash, and arthralgia (Silva and Dermody 2017; Suhrbier 2019). It was first reported in 1953 in Tanzania, and caused only a few outbreaks and sporadic cases in Africa and Asia in last century. However, in the epidemic in 2004, CHIKV acquired mutations that conferred enhanced transmission by the A. albopictus mosquito(Schuffenecker et al. 2006). Since then, it has successively caused outbreaks in Africa, the Indian Ocean, South East Asia, the South America, and Europe (Zeller et al. 2016).     

Development of a Novel Reverse Transcription Loop-Mediated Isothermal Amplification Method for Rapid Detection of SARS-CoV-2

In conclusion, the novel visual RT-LAMP assay is a simple, rapid, and sensitive approach for detection of SARS-CoV-2, and it is ready for application in primary care and community hospitals or health care centers, and even patients' own houses in response to the current SARS-CoV-2 epidemic because the assay does not require sophisticated equipment and skilled personnel. Furthermore, it is also ready to be used in fields for screening samples from wild animals and environments to facilitate the identification of potential intermediate hosts that mediate the cross-species transmission of SARS-CoV-2 from bats to humans.