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Although cortical nonmuscle myosin II has long been implicated in cytokinetic aspects of cell division, there has never been strong evidence that it plays a role in the organization of the mitotic spindle. ([this issue of Cell]) use a number of methods to show that cortical myosin II is in fact important for spindle assembly in higher eukaryotic cells, specifically for the complete separation of centrosomes after nuclear envelope breakdown. 相似文献
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In many insects, X‐linked inversions fix at a higher rate and are much less polymorphic than autosomal inversions. Here, we report that in Drosophila, X‐linked inversions also capture 67% more genes. We estimated the number of genes captured through an approximate Bayesian computational analysis of gene orders in nine species of Drosophila. X‐linked inversions fixed with a significantly larger gene content. Further, X‐linked inversions of intermediate size enjoy highest fixation rate, while the fixation rate of autosomal inversions decreases with size. A less detailed analysis in Anopheles suggests a similar pattern holds in mosquitoes. We develop a population genetic model that assumes the fitness effects of inversions scale with the number of genes captured. We show that the same conditions that lead to a higher fixation rate also produce a larger size for inversions on the X. 相似文献
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