PRC2.1- and PRC2.2-specific accessory proteins drive recruitment of different forms of canonical PRC1

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PALI1 promotes tumor growth through competitive recruitment of PRC2 to G9A-target chromatin for dual epigenetic silencing

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Distinct PRC2 subunits regulate maintenance and establishment of Polycomb repression during differentiation

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PRC1 Catalytic Activity Is Central to Polycomb System Function

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A Dimeric Structural Scaffold for PRC2-PCL Targeting to CpG Island Chromatin

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DEAD-Box Helicase 18 Counteracts PRC2 to Safeguard Ribosomal DNA in Pluripotency Regulation

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Two modes of PRC1-mediated mechanical resistance to kinesin-driven microtubule network disruption

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Salmonella Effector SteE Converts the Mammalian Serine/Threonine Kinase GSK3 into a Tyrosine Kinase to Direct Macrophage Polarization

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A Polycomb domain found in committed cells impairs differentiation when introduced into PRC1 in pluripotent cells

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SETDB1-Mediated Cell Fate Transition between 2C-Like and Pluripotent States

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TIR domains of plant immune receptors are 2′,3′-cAMP/cGMP synthetases mediating cell death

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Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells

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Atomic insights into ML-SI3 mediated human TRPML1 inhibition

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Microtubule-sliding modules based on kinesins EG5 and PRC1-dependent KIF4A drive human spindle elongation

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ORF3a of SARS-CoV-2 promotes lysosomal exocytosis-mediated viral egress

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Histone H2AK119 Mono-Ubiquitination Is Essential for Polycomb-Mediated Transcriptional Repression

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Histone phosphorylation integrates the hepatic glucagon-PKA-CREB gluconeogenesis program in response to fasting

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The Salmonella Secreted Effector SarA/SteE Mimics Cytokine Receptor Signaling to Activate STAT3

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The Polycomb group protein MEDEA controls cell proliferation and embryonic patterning in Arabidopsis

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The gut peptide Reg3g links the small intestine microbiome to the regulation of energy balance,glucose levels,and gut function

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