南瓜多糖对糖尿病大鼠血糖和血脂的影响

目的：研究南瓜多糖对糖尿病大鼠血糖和血脂的影响。方法：Wistar大鼠腹腔注射四氧嘧啶后。将成模的糖尿病大鼠根据血糖和体重随机分为糖尿病组、消渴丸组和南瓜多糖组,同时设立正常对照组,并分别给予蒸馏水、消渴丸和南瓜多糖灌胃,每周测量体重一次,四周后测定空腹血糖、血清总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白和游离脂肪酸的含量。结果：糖尿病组大鼠体重下降,血糖显著升高,甘油三酯、总胆固醇、低密度脂蛋白和游离脂肪酸含量显著增加,而高密度脂蛋白含量显著降低;补充南瓜多糖和消渴丸后,体重逐渐增加,血糖显著下降,总胆固醇、甘油三酯、低密度脂蛋白和游离脂肪酸含量显著降低,高密度脂蛋白含量显著升高,并且南瓜多糖的降糖降脂效果优于消渴丸。结论：南瓜多糖能增加体重,降低糖尿病大鼠血糖、血脂,对糖尿病及其并发症有一定的作用。     

镁补充对2 型糖尿病大鼠糖脂代谢的影响

目的:研究镁补充对2型糖尿病大鼠糖脂代谢的影响。方法:将用高脂饮食联合链脲佐菌素(STZ)方法诱发的2型糖尿病大鼠随机分为四个组,糖尿病对照组喂饲高脂饲料,高、中、低剂量组在高脂饲料中分别加入2000、1000、200 mg/kg的镁(以镁离子计)。自由饮食喂养四周,处死动物。用放射免疫法测血清胰岛素(Ins)水平、用葡萄糖氧化酶法测空腹血浆葡萄糖(fasting plasmaglucose,FPG),并计算胰岛素敏感指数(insulin sensitivity index,ISI)。比色法检测糖化血红蛋白(glycosylated hemoglobin,HbA1c)。用全自动生化分析仪测高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDLC)、甘油三酯(triglyceride,TG)、总胆固醇(total cholesterol,TC)。结果:高剂量组的空腹血糖、空腹血清、糖化血红蛋白、甘油三酯、总胆固醇水平均较糖尿病对照组显著性降低(P<0.05),而高密度脂蛋白胆固醇、胰岛素敏感指数较糖尿病对照组显著性升高(P<0.05)。结论:镁补充可以提高2型糖尿病大鼠胰岛素敏感性,改善糖尿病大鼠的糖脂代谢情况。     

沙棘籽渣多糖对正常及糖尿病模型动物血糖的影响

本文研究了沙棘籽渣多糖(Polysaccharides from seed residue of Hippophae rhamnoide L.,PSH)对正常小鼠及实验性2型糖尿病大鼠血糖、血脂代谢的影响.以100、200和400 mg/kg剂量的PSH连续灌胃正常小鼠20d;以50和100 mg/kg剂量的PSH连续灌胃由烟酰胺联合链脲佐菌素诱导的类似2型糖尿病大鼠3周,测定血糖、糖基化血清蛋白、血清胰岛素、血清总胆固醇、甘油三酯及肝糖原含量.结果显示:PSH对正常小鼠的血糖和血脂代谢没有明显影响;但能明显降低2型糖尿病大鼠的血清葡萄糖、总胆固醇和糖基化血清蛋白水平,同时显著增加糖尿病大鼠的血清胰岛素含量.上述结果表明:PSH在实验性2型糖尿病大鼠模型上具有降血糖和降胆固醇的活性.     

有机铬对实验性糖尿病大鼠胰岛β细胞形态结构及功能的影响

目的探讨有机铬(2-吡啶甲酸铬)对大鼠胰岛β细胞形态结构及内分泌功能的影响。方法首先通过尾静脉注射新鲜配制的1.5%四氧嘧啶溶液制备糖尿病大鼠模型;通过灌胃的方式提高糖尿病大鼠体内有机铬含量;治疗12周后,通过氧化酶法测定大鼠血清葡萄糖水平,利用免疫组织化学方法和放射免疫学方法分别观察大鼠胰岛β细胞形态结构的改变及大鼠血清胰岛素含量的变化。结果两治疗组大鼠血清葡萄糖水平明显下降,与糖尿病模型组相比,差异均有显著性;400μg治疗组大鼠体内胰岛素水平明显升高,与糖尿病模型组相比差异有显著性,而200μg治疗组大鼠血清胰岛素水平虽有所增加但与糖尿病组相比,差异无显著性;免疫组化显示治疗组大鼠胰岛β细胞数量增多,胞质内胰岛素免疫反应阳性颗粒明显增多。结论有机铬对糖尿病大鼠具有明显的降低血糖功能,并能促进受损胰岛及β细胞形态结构功能的恢复,对糖尿病大鼠病理状态具有明显的改善作用。     

燕麦低聚肽对糖尿病大鼠血糖的影响

目的：研究燕麦低聚肽（Oat oligopeptides,OOPs）对高热能饮食联合链脲佐菌素（streptozotocin,STZ）诱导糖尿病大鼠血糖的影响作用。方法：采用SD大鼠经高热能饲料喂养45d后腹腔注射2次30mg/kg链脲佐菌素（注射间隔为6d）,造成2型糖尿病大鼠模型。成模后随机分为燕麦低聚肽组（0.50、1.00、2.00g/kg·BW、糖尿病模型对照组、二甲双胍对照组、乳清蛋白对照组和空白对照组。经过为期15w的干预,检测大鼠空腹血糖、血糖曲线下面积及血脂四项（血清总胆固醇、甘油三脂、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇）。结果：燕麦低聚肽可降低糖尿病大鼠空腹血糖水平并改善糖耐量（P＜0.05）,以2.00g/kg·BW剂量效果最好。结论：长期燕麦低聚肽干预可有效降低糖尿病大鼠的血糖水平,降低血糖曲线下面积,具有辅助降血糖功能。     

野生地参多糖对四氧嘧啶致糖尿病小鼠血糖和血脂的影响

为了研究野生地参多糖对四氧嘧啶(ALX)致糖尿病小鼠血糖和血脂的影响,利用四氧嘧啶(ALX)建立糖尿病小鼠模型,分别灌胃低(100 mg/(kg.d))、中(200 mg/(kg.d))、高(400 mg/(kg.d))剂量地参多糖溶液及阳性对照药盐酸苯乙双胍,正常对照组及糖尿病模型对照组则给等体积生理盐水。结果表明:连续给药14 d后,地参多糖对正常小鼠血糖无明显影响,100、200和400 mg/(kg.d)地参多糖均能明显降低ALX所致糖尿病小鼠高血糖,与糖尿病模型对照组相比,P<0.01;同时,相同剂量的地参多糖还能极显著降低ALX致糖尿病小鼠血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)(P<0.01)。中、高剂量地参多糖使糖尿病小鼠血清高密度脂蛋白胆固醇(HDL-C)显著回升(P<0.05),但低剂量地参多糖对糖尿病小鼠血清HDL-C则无明显影响(P>0.05)。地参多糖能明显降低ALX致糖尿病小鼠高血糖及高血脂。     

全身稳恒磁场暴露对糖尿病性动脉粥样硬化大鼠血脂和血液流变学的影响

目的:探索全身暴露强度为4.0 m T中强度稳恒磁场对于糖尿病性动脉粥样硬化的血脂和血液流变学影响,以明确稳恒磁场对糖尿病性动脉粥样硬化的潜在作用效果。方法:选择3月龄雄性SD大鼠30只,随机等分至空白对照组、糖尿病组及糖尿病磁场暴露组。糖尿病和糖尿病磁场暴露组的大鼠采用链脲佐菌素+维生素D3+高脂饮食组合作用法建立糖尿病性动脉粥样硬化大鼠模型,对糖尿病磁场暴露组施加2小时/天、强度为4.0 m T的全身稳恒磁场暴露,连续刺激8周后,检测空腹血糖、血清胰岛素、血脂四项(血清总胆固醇、甘油三酯、高密度脂蛋白胆固醇以及低密度脂蛋白胆固醇)以及血液流变参数(低切全血粘度、中切全血粘度、高切全血粘度以及血浆粘度)。结果:稳恒磁场暴露显著抑制了糖尿病动脉粥样硬化大鼠血清总胆固醇、甘油三酯、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇的升高(P0.05),同时也显著降低了低切、中切和高切全血粘度以及血浆粘度(P0.05),但对血糖和血清胰岛素的影响不显著(P0.05)。结论:中强度稳恒磁场可显著降低糖尿病性动脉粥样硬化大鼠的血脂水平并改善其血液流变学。     

2型糖尿病大鼠主动脉硬化模型的构建

目的:建立自发2型糖尿病大鼠主动脉硬化动物模型.方法:用2型糖尿病大鼠主动脉硬化动物模型,44只GK大鼠随机分为正常GK对照组、建模组,每组22只,正常Wistar大鼠组22只.期间观察大鼠血糖、尿糖及一般情况变化,8周后,测定各组动物空腹血糖、总胆固醇(total cholesterol,TC)、甘油三酯(triglycerides,TG)、低密度脂蛋白胆固醇(low density lipoprotein choleste rol,LDL-C),同时光学显微镜观察主动脉结构.结果:模型组大鼠的总胆固醇、甘油三酯、低密度脂蛋白胆固醇明显升高,出现主动脉肥大,病理显示明显的主动脉及动脉内膜病变.结论:通过高脂、一氧化氮合成酶抑制剂,可成功构建自发2型糖尿痛大鼠主动脉病变,用作2型糖尿病大鼠大血管病变研究的动物模型.     

栀子水提取物对实验性2型糖尿病大鼠血糖及同型半胱氨酸水平的影响

观察栀子提取物对实验性2型糖尿病大鼠血糖、血脂及同型半胱氨酸水平的影响.采用Wistar雄性大鼠70只,随机抽取10只作为正常对照组,喂以普通维持饲料,其余60只高糖高脂饲料喂养4周后,ip链脲佐菌素(STZ)30 mg/kg建立2型糖尿病模型,7d后选取成模大鼠50只随机分为模型对照组(生理盐水)、盐酸二甲双胍对照组、栀子提取物低、中、高剂量组(0.2、0.4、0.6 g/kg),每组10只.连续ig给药4周后,观察各组大鼠血糖、血脂及同型半胱氨酸水平等变化.栀子提取物ig能降低糖尿病大鼠的血糖、甘油三酯(TG)、胆固醇(TC)、低密度脂蛋白(LDLC),同时能升高高密度脂蛋白(HDLC),降低同型半胱氨酸水平.     

降浊颗粒预防性给药对实验性高脂血症大鼠血脂含量的影响

目的:研究降浊颗粒对实验性高脂血症大鼠血脂含量的影响。方法:采用高脂高胆固醇饲喂大鼠4周,建立大鼠高脂血症模型,造模同时给药,分别于给药第2、4周后剪尾取血,检测血清中总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)含量。结果:降浊颗粒分别以800mg/kg、400mg/kg和200mg/kg给大鼠预防性灌胃2周及4周时,均具有明显降低高脂模型动物血清TC、TG和LDL-cho含量,同时使TC/HDL-cho比值也明显降低的作用(与模型组比较分别为(P<0.001;P<0.01或P<0.05),并具有良好的量-效关系。结论:降浊颗粒可明显抑制实验性大鼠高脂血症的形成,主要能明显降低血清总胆固醇、甘油三酯和低密度脂蛋白胆固醇含量。     

Type 2 Diabetic Rats on Diet Supplemented With Chromium Malate Show Improved Glycometabolism,Glycometabolism-Related Enzyme Levels and Lipid Metabolism

Our previous study showed that chromium malate improved the regulation of blood glucose in mice with alloxan-induced diabetes. The present study was designed to evaluate the effect of chromium malate on glycometabolism, glycometabolism-related enzymes and lipid metabolism in type 2 diabetic rats. Our results showed that fasting blood glucose, serum insulin level, insulin resistance index and C-peptide level in the high dose group had a significant downward trend when compared with the model group, chromium picolinate group and chromium trichloride group. The hepatic glycogen, glucose-6-phosphate dehydrogenase, glucokinase, Glut4, phosphor-AMPKβ1 and Akt levels in the high dose group were significantly higher than those of the model, chromium picolinate and chromium trichloride groups. Chromium malate in a high dose group can significantly increase high density lipoprotein cholesterol level while decreasing the total cholesterol, low density lipoprotein cholesterol and triglyceride levels when compared with chromium picolinate and chromium trichloride. The serum chromium content in chromium malate and chromium picolinate group is significantly higher than that of the chromium trichloride group. The results indicated that the curative effects of chromium malate on glycometabolism, glycometabolism-related enzymes and lipid metabolism changes are better than those of chromium picolinate and chromium trichloride. Chromium malate contributes to glucose uptake and transport in order to improved glycometabolism and glycometabolism-related enzymes.     

The effects of dietary chromium supplementation on some blood parameters in sheep

The effects of dietary inorganic chromium on some biochemical parameters were determined in lambs fed either a control diet or a 200-ppb or 400-ppb chromium-supplemented diet. The live weight of the animals were measured and jugular blood samples were collected prior to supplementation (d 0) and on d 20, 40, and 55. On d 55, three animals from each group were slaughtered to measure subcutaneous fat. Sera were analyzed for glucose, triglyceride, total cholesterol, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, total protein, albumin, ALT, AST, and GGT levels. Chromium supplementation had no significant effect on live weight, but subcutaneous fat was reduced significantly in both chromium groups. There was a slight decrease in glucose concentrations in the 200-ppb chromium group, although only the differences on d 55 were significant. Triglyceride levels in both chromium groups were lower than the control group with marked differences in the 400-ppb chromium group. HDL cholesterol levels increased in both treatment groups compare to control, although the differences in the 400-ppb chromium group on d 40 were significant. Serum Cr concentrations slightly but not significantly increased in both chromium groups. No significant differences were found in total and LDL cholesterol, total protein, albumin, ALT, AST, and GGT levels. In conclusion, chromium supplementation may affect carbohydrate and lipid metabolisms and lipid deposition in lambs.     

有机铬、炎症与胰岛素抵抗的相关性

目的研究有机铬、炎症、他汀类药物与胰岛素抵抗,及其与心、脑血管疾病方面的关系。方法筛选40岁以上的糖耐量异常(IGT)合并高血压患者60人、糖耐量异常合并高脂血症患者60人、糖耐量异常合并冠心病患者60人和非胰岛素依赖性糖尿病(T2DM)患者60人,进行分组,每一组随机分为3个小组:2个治疗组及对照组。治疗一组在原治疗方案基础上给予唐安一号(有机铬制剂)口服,治疗二组在原治疗方案基础上给予阿乐(阿托伐他汀钙片)口服,对照组维持原治疗方案,治疗4周。结果治疗一组空腹血糖(FBG)、空腹血清胰岛素(FINS)、甘油三酯(TG)、血清总胆固醇(TC)和血清低密度脂蛋白胆固醇(LDL-C)均低于对照组(P0.05),血清高密度脂蛋白胆固醇(HDL-C)高于对照组(P0.05)。治疗二组FINS、TG、TC、LDL-C和C-反应蛋白(CRP)低于对照组(P0.05),HDL-C高于对照组(P0.05)。4周治疗后,治疗一组、治疗二组HOMA-IR均低于对照组(P0.05)。结论有机铬及他汀类药物能增强胰岛素的生物学效应,调节糖脂代谢,改善胰岛素抵抗。     

The Effect of Boron on Some Biochemical Parameters in Experimental Diabetic Rats

In this study, we evaluated the effect of boron (B) as boric acid (BA) on body weight (b.w.); blood glucose; plasma insulin; lipase and paraoxonase (PON1) activities; and serum triglyceride, total cholesterol, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, lipid peroxidation (MDA), and total antioxidant capacity (TAC) in streptozotocin (STZ)-induced experimental diabetes in rats. Sixty Wistar albino rats (200–250 g) were divided into six groups of ten. The groups received the following treatment: group 1, control group; group 2, 50 mg/kg (b.w.) i.p. STZ-induced diabetes; group 3, 5 mg/kg (b.w.) B; group 4, 10 mg/kg (b.w.) B; group 5, diabetes + 5 mg/kg (b.w.) B; and group 6, diabetes + 10 mg/kg (b.w.) B. The experiment lasted 4 weeks. Increased serum MDA levels with diabetes were significantly reduced and although it is not statistically significant, serum TAC levels approached to values of control group; also, insignificant increases were observed in HDL cholesterol levels in experimental diabetic rats with treatment 5 and 10 mg/kg B. Furthermore, body weight, plasma insulin, and lipase activities increased insignificantly, blood glucose and serum LDL cholesterol decreased significantly, and total cholesterol levels decreased insignificantly in the diabetes + 10 mg/kg B group. There was no difference between the groups in terms of plasma PON1 activities and serum triglyceride levels. In conclusion, B may have beneficial effects on some biochemical parameters changes in experimental diabetes, and in order to determine the full effect of this element on the metabolism, further studies are required which use various dosages and compounds of B.     

Effects of oral zinc and magnesium supplementation on serum thyroid hormone and lipid levels in experimentally induced diabetic rats

This study was designed to investigate the effects of oral zinc and magnesium supplementation on serum thyroid hormone and lipid levels in alloxan-induced diabetic rats. Thirty-two albino male rats, weighing 234±34 g, were divided into four experimental groups (control, diabetic, diabetic+zinc supplemented and diabetic+ magnesium supplemented). The experiment lasted for 60 d. The first 45 d of the experiment was the supplementation and last 15 d was the supplementation and diabetes-inducing period. Diabetic+zinc-supplemented and diabetic+magnesium-supplemented groups were given orally (by adding in their drinking water) 227 mg/L of zinc and 100 mg/kg body weight (bw) of magnesium, respectively throughout the experiment. Control and diabetic groups served as controls and did not receive zinc or magnesium supplementation. Diabetic, diabetic+zinc-supplemented, and diabetic+magnesium-supplemented groups were given a daily injection (ip) of 100 mg/kg bw of alloxan for 15 d starting on d 46 of the experiment. The control group was only injected with the same volume of isotonic NaCl as the diabetic group received. At the end of the of the experiment, rats in all four groups were fasted for 12 h and blood samples were taken from the heart under ether anesthesia for the determination of thyroid hormone, glucose, total cholesterol, and triglyceride concentrations. It was found that serum glucose, total cholesterol, and triglyceride concentrations were higher and serum T3 and T4 concentrations were lower in diabetic rats than those in the control group. Zinc supplementation did not change any parameter in diabetic rats. However, magnesium supplementation decreased the elevated total cholesterol and triglyceride concentrations of the diabetic rats to the control level. It was concluded that oral magnesium supplementation might decrease the diabetes-induced disturbances of lipid metabolism.     

有氧运动和谷氨酰胺对二型糖尿病大鼠氧化应激及相关因子表达的影响

目的:探讨有氧运动和谷氨酰胺(Gln)对二型糖尿病(T2MD)大鼠抗氧化应激及炎性因子的影响。方法:用链脲佐菌素(STZ)诱导糖尿病大鼠模型,将成年雄性SD大鼠50只,6周龄,随机分为5组(n=10):包括安静对照组(N)、糖尿病对照组(D)、糖尿病施加有氧运动组(DE)、糖尿病施加谷氨酰胺组(DG)、糖尿病施加有氧运动+谷氨酰胺组(DEG)。6周后,检测干预后糖尿病大鼠糖脂代谢、抗氧化应激及炎性因子等相关指标,并探讨影响炎症反应的可能机制。结果:与N组相比,D组大鼠血清MDA、血糖、TC、TG、胰岛素、瘦素、TNF-α水平均明显升高(P<0.01),血清中SOD、GSH-Px、脂联素、HDL-C的水平均明显降低(P<0.01);与D组相比,三个干预组血清中MDA、血糖、TC、TG、胰岛素、瘦素、TNF-α水平降低,血清中HDL-C、SOD、GSH-Px、脂联素的水平均明显升高(P<0.05,P<0.01),且两者联合对上述指标的改善作用更为明显(P<0.01)。结论:有氧运动和Gln均能缓解糖尿病大鼠糖脂代谢及紊乱、氧化应激损伤及炎症反应,两者联合对其作用优于单一作用。     

Antidiabetic potential of oleanolic acid from Ligustrum lucidum Ait

Ligustrum lucidum Ait. has been used in traditional Chinese medicine for over 1000 years because of its anti-tumor, antimutagenic, antidiabetic, and hepatoprotective properties. The aim of this study was to determine whether oleanolic acid (OA) is the principal active compound of L. lucidum responsible for its antidiabetic properties, and to examine its effect on the expression of thyroid hormones and insulin secretion, thus revealing the mechanism by which L. lucidum modulates insulin levels in diabetes. When rats with streptozotocin-induced diabetes were treated with OA (100 and 200 mg/kg body mass per day, for 40 days), the changes in blood glucose levels and in oral glucose tolerance tests showed that hypoglycemia was more pronounced in OA-treated groups than in the diabetic control rats, and that the levels of triglyceride, total cholesterol, and low-density lipoportein cholesterol in OA-treated rats were lower than those in the diabetic control rats, whose high-density lipoprotein cholesterol increased. OA-treated rats also gained weight, and exhibited increased serum insulin levels. In contrast, OA treatment did not effect the levels of thyroid hormone or TSH in rats with streptozotocin-induced diabetes. These results indicate that OA has hypoglycemic and hypolipidemic effects. OA treatment might stimulate insulin release, and consequently, results in the modulation of glucose levels and regulation of lipid metabolism.     

瘦素对糖尿病大鼠糖脂代谢及炎性因子的影响

目的: 探讨瘦素对糖尿病大鼠糖脂代谢及相关炎症因子的影响。方法: 将健康Wistar雄性大鼠60只随机选取10只作为对照组,50只给予高糖高脂饲料喂养加腹腔内注射链脲佐霉素(STZ,25 mg/kg)的方法诱发并建立糖尿病大鼠模型。并随机分为模型组、瘦素低剂量组、瘦素中剂量组和瘦素高剂量组,每组10只。4组大鼠造模成功后均持续给予高糖高脂饲料喂养,瘦素低、中、高剂量组给予20 μg/kg、50 μg/kg和100 μg/kg,连续5 d。GOD-PAP法检测大鼠血糖(FBG),放射免疫法测定胰岛素含量(Ins),全自动生化分析仪测定血清中三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)。采用酶联免疫方法(ELISA)测定丙二醛(MDA)、白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)。采用Western blot检测糖尿病大鼠脂肪组织中瘦素表达情况。结果: 与对照组比较,各组大鼠血糖水平均显著升高(P＜0.01);与模型组比较,瘦素中、高剂量大鼠血糖显著降低(P＜0.05,P＜0.01);瘦素高剂量组胰岛素水平显著降低(P＜0.01)。不同剂量瘦素组间比较,给药后三组大鼠FBG及INS无统计学差异(P＞0.05)。与模型组比较,瘦素中、高剂量组TC水平显著下降(P＜0.05,P＜0.01);高剂量组TG、LDL-C水平显著降低(P＜0.05),高剂量组HDL-C水平显著升高(P＜0.01)。不同剂量瘦素组进行组间比较,高剂量组在降低TC、TG、LDL-C水平,升高HDL-C水平优于中、低剂量组(P＜0.05)。Western blot结果显示,与模型组(52.27±10.93)比,瘦素高剂量组100 μg/kg(40.13±9.87)、中剂量组50 μg/kg(44.68±10.23)、低剂量组20 μg/kg(47.35±12.09)脂肪中瘦素表达水平依次降低。结论: 瘦素水平分泌异常是诱发糖尿病因素之一,在给予一定浓度外源性瘦素(100 μg/kg)干预下,能显著降低MDA、TNF-α水平,提高IL-6水平,其机制可能与瘦素在减轻炎症反应、氧化应激,纠正血脂异常紊乱有密切关系。     

Modulatory effects of one polysaccharide from Acanthopanax senticosus in alloxan-induced diabetic mice

One water-soluble polysaccharide ASP was purified from Acanthopanax senticosus and its physicochemical properties were confirmed by the combination of chemical and instrumental analysis. ASP administered orally at three doses (100, 200 and 400 mg/kg body weight) could significantly decrease the concentration of total cholesterol (TC), triglyceride (TG) and low-density lipoprotein (LDL) cholesterol levels except for high density lipoprotein (HDL) cholesterol level and the relative ratio (HDL/TC) in alloxan-induced diabetic mice, compared with the diabetic controls without drug treatment, comparable with that of diabetic mice treated with metformin. Furthermore, ASP could obviously increase the body weight and serum insulin level and reduce the fasting blood glucose (FBG) levels, especially at dose of 200 mg/kg. The data demonstrated ASP at the certain did often exhibit the optimal protective effect in alloxan-induced diabetic mice. It is promising that ASP may serve as a drug candidate or a healthcare food for diabetic therapy or protection.     

Relations of serum interleukin 18 levels to serum lipid and glucose concentrations in an apparently healthy adult population

AIM: To investigate the associations between serum interleukin (IL) 18 concentrations and indices of lipid and carbohydrate metabolism in healthy adults. METHODS: Fasting serum concentrations of IL-18, glucose, total cholesterol, triglyceride, and high- and low-density lipoprotein cholesterols were measured in 570 apparently healthy adults. RESULTS: Univariate linear and partial regression analyses showed that the serum IL-18 concentration was positively correlated with serum triglyceride and glucose concentrations in both obese and diabetic subjects after controlling for the confounding effects of age, sex, and body mass index. CONCLUSION: IL-18 may be associated with obesity and glucose intolerance.