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《Cell host & microbe》2014,15(1):103-112
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Highlights? ADF/cofilin localizes to the TGN and binds SPCA1 in an actin-dependent manner ? Dynamic actin regulates the activity of the Ca2+ pump SPCA1 ? ADF/cofilin facilitates secretory cargo sorting in a Ca2+-dependent manner  相似文献   

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Highlights? Two conformations of yeast V-ATPase EGChead peripheral stalk complex were solved ? The EG heterodimer of the eukaryotic V-ATPase forms a noncanonical coiled coil ? Subunit G contains a conserved random coiled bulge that interrupts the coiled coil ? The EGChead interaction represents an important target for therapeutic development  相似文献   

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Highlights? Proteasome ATPase Rpt6 undergoes helix-coil exchange in its C-terminal domain ? Rpt6 G360,387A has a stabilized four-helix bundle and raised melting temperature ? Assembly chaperone Rpn14 binds selectively to the four-helix bundle Rpt6 conformer ? Rpt6 G360,387A (rpt6AA) is synthetically defective with an rpn14 null mutation  相似文献   

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