Genome-wide Screening Identifies SFMBT1 as an Oncogenic Driver in Cancer with VHL Loss

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Chk1 promotes non-homologous end joining in G1 through direct phosphorylation of ASF1A

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Definition of a small core transcriptional circuit regulated by AML1-ETO

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TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1

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Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism

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A unique macrophage subpopulation signals directly to progenitor cells to promote regenerative neurogenesis in the zebrafish spinal cord

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H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ

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Kinetochore stretching-mediated rapid silencing of the spindle-assembly checkpoint required for failsafe chromosome segregation

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Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex

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Nesprin-2 Recruitment of BicD2 to the Nuclear Envelope Controls Dynein/Kinesin-Mediated Neuronal Migration In Vivo

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TIM23 facilitates PINK1 activation by safeguarding against OMA1-mediated degradation in damaged mitochondria

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Visualization of Ligand-Bound Ectodomain Assembly in the Full-Length Human IGF-1 Receptor by Cryo-EM Single-Particle Analysis

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CtBP1-Mediated Membrane Fission Contributes to Effective Recycling of Synaptic Vesicles

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The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling

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Tim4 recognizes carbon nanotubes and mediates phagocytosis leading to granuloma formation

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Sen1 Is Recruited to Replication Forks via Ctf4 and Mrc1 and Promotes Genome Stability

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BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation

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Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription

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AMPK,a Regulator of Metabolism and Autophagy,Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System

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An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis

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