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D—氨基酸在人体的来龙去脉:人体中D—氨基酸,D—氨基酸氧化酶,D… 总被引:4,自引:0,他引:4
本文分析近年,特别是近两年有关人体、食物中D-氨基酸、D-氨基酸氧化酶、D-天冬氨酸氧化酶研究进展,强调:1.必须研究食品中D-氨基酸水平;2.D-氨基酸氧化酶、D.天冬氨酸氧化酶作为药物治疗因D-氨基酸过量所致疾病。 相似文献
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本文分析近年,特别是近两年有关人体、食物中D-氨基酸、D-氨基酸氧化酶、D-天冬氨酸氧化酶研究进展,强调:1.必须研究食品中D-氢基酸水平;2.D-氨基酸氧化酶、D-天冬氨酸氧化酶作为药物治疗因D-氨基酸过量所致疾病。 相似文献
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A preponderance of evidence supports a role for vitamin D beyond the classical function in mineral homeostasis. Epidemiologic investigations have revealed a beneficial role of vitamin D in muscle function, cardiovascular health, diabetes, and cancer prevention. More recently, studies have suggested a potential beneficial role of vitamin D in cognitive function. Vitamin D exhibits functional attributes that may prove neuroprotective through antioxidative mechanisms, neuronal calcium regulation, immunomodulation, enhanced nerve conduction and detoxification mechanisms. Compelling evidence supports a beneficial role for the active form of vitamin D in the developing brain as well as in adult brain function. The vitamin D receptor and biosynthetic and degradative pathways for the hydroxylation of vitamin D have been found in the rodent brain; more recently these findings have been confirmed in humans. The vitamin D receptor and catalytic enzymes are colocalized in the areas of the brain involved in complex planning, processing, and the formation of new memories. These findings potentially implicate vitamin D in neurocognitive function. 相似文献
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The potential energy surfaces of several alpha-(1-->3)- and beta-(1-->4)-linked disaccharides were obtained and plotted in terms of energy versus psi glycosidic angle. These plots were compared to those obtained previously in the way of the usual 3D contour maps, which relate the energy with the two glycosidic angles (phi and psi). Given the usually small variations of the phi angle in the low-energy regions (at least using MM3), both kinds of graphs lead to similar conclusions concerning flexibility measurements by two different methods and assessment of the effects of sulfation and/or hydroxyl group orientation. Only second-order effects were found with some sulfated disaccharides, not changing the general conclusions. The computational efforts required to produce those plots are smaller, and the plots are easier to interpret. Besides, the conversion of a 3D map into a 2D plot leaves the possibility of constructing 3D maps of carbohydrates including a second variable different to phi, e.g., the second psi angle of a trisaccharide or the omega angle of a 6-linked disaccharide. 相似文献
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目的:探讨怀孕早期维生素D水平及相关影响因素。方法:选取北京儿童医院顺义妇儿医院建档的387名孕早期妇女,由统一培训的专业人员收集其基本信息。早上空复采血后,检测维生素D浓度并收集维生素D代谢相关基因位点的SNPs数据。结果:孕妇维生素D总体水平为(20.13±9.11)ng/mL,维生素D不足率为91.2%。维生素D浓度与年龄、孕前BMI、孕次、产次、GCrs7041多态性等相关性无统计学差异(P>0.05);与GCrs2282679多态性相关(P<0.05),与T/T型相比,G/G型维生素D浓度低3.46个单位(95% CI -6.53~-0.39,P=0.027),G/T型维生素D浓度低1.75个单位(95% CI-3.65~0.16,P=0.073)。Logistic回归分析显示,GCrs2282679的G/G型具有较高的维生素D缺乏程度(OR=0.273,95% CI 0.126~0.592,P=0.001),而高年龄人群具有较低的维生素D缺乏程度(OR=2.679,95% CI 1.040~6.902,P=0.041)。结论:怀孕早期孕妇维生素D普遍不足,且维生素D浓度与GCrs2282679的多态性有关,有必要开展进一步研究。 相似文献
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维生素并不是补品,人体每天需要有一定的范围,若使用不当,反而会导致疾病。下面浅谈一下维生素D和A过多症。 (一) 维生素D过多症维生素D缺乏引起的佝偻病是小儿四大常见病之一,然而补充维生素D制剂常出现偏差,补充不足无效,但如过量引起维生素D中毒,对婴幼儿的健康威胁颇大,因为维生素D是一种蓄积性药物,可长期贮存于体内脂肪和肌肉中,短期超量误用或长期大量使用,尤其是在长期大量口服鱼肝油的基础上注射维生素D,更容易发生中毒现象。维生素D中毒时,首先动员骨胳中的钙进入血液,引起血液中钙浓度升高。当血清钙超过2.8毫摩尔/升时,可发生高钙血症,导致钙磷代谢紊乱。骨胳中的钙 相似文献
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