共查询到20条相似文献,搜索用时 46 毫秒
1.
Tamar Hermesh Bruno Moltedo Thomas M. Moran Carolina B. López 《Cell host & microbe》2010,7(5):343-353
Highlights? Lung-produced type I interferons instruct bone marrow cells during respiratory virus infections ? IFN-exposed bone marrow leukocytes become resistant to virus infection ? Primed and protected bone marrow leukocytes migrate to the infected lung and contribute to virus clearance 相似文献
2.
Highlights? C. elegans DAF-2 insulin-like signaling negatively regulates HSF-1 activity ? DDL-1 and DDL-2 are negative regulators of HSF-1 ? Formation of a complex containing DDL-1/2 and HSF-1 inhibits HSF-1 activity ? DAF-2 signaling promotes DHIC formation by inhibiting DDL-1 phosphorylation 相似文献
3.
Cyril Hamiaux Revel S.M. Drummond Bart J. Janssen Susan E. Ledger Janine M. Cooney Richard D. Newcomb Kimberley C. Snowden 《Current biology : CB》2012,22(21):2032-2036
Highlights? DAD2 gene, identified by transposon tagging, encodes an α/β hydrolase fold protein ? DAD2 acts in the shoot; mutants are insensitive to strigolactones ? DAD2 crystal structure shows an internal cavity capable of binding strigolactones ? DAD2 can hydrolyze the strigolactone GR24 相似文献
4.
Quin MB Berrisford JM Newman JA Baslé A Lewis RJ Marles-Wright J 《Structure (London, England : 1993)》2012,20(2):350-363
Highlights? Regulation of cyclic di-GMP biosynthesis in Moorella thermoacetica ? Stressosome signal transduction and resetting ? X-ray crystal structure of type 2C phosphatase MtX ? X-ray crystal structures of phosphorylated MtS and the N-terminal domain of MtR 相似文献
5.
Peter Reinhardt Benjamin Schmid Lena F. Burbulla David C. Schöndorf Lydia Wagner Michael Glatza Susanne Höing Gunnar Hargus Susanna A. Heck Ashutosh Dhingra Guangming Wu Stephan Müller Kathrin Brockmann Torsten Kluba Martina Maisel Rejko Krüger Daniela Berg Yaroslav Tsytsyura Jared Sterneckert 《Cell Stem Cell》2013,12(3):354-367
Highlights? hiPSC-derived neurons with LRRK2 G2019S exhibit Parkinsonian neurodegeneration ? Genetic correction of the LRRK2 mutation rescued neurodegenerative phenotypes ? Comparative analysis links LRRK2 G2019S, gene dysregulation, and ERK activation ? ERK-dependent gene dysregulation by LRRK2 G2019S contributes to neurodegeneration 相似文献
6.
Highlights? Gene expression noise is an efficient means to probe dose responses ? Variability in MYC reveals biphasic E2f1 dose response ? Modeling predicts serum attenuates E2F repression by MYC ? Biphasic expression underlies discrimination of aberrant levels of growth signaling 相似文献
7.
Ying Tian Lijun Yuan Ashley M. Goss Tao Wang Jifu Yang John J. Lepore Diane Zhou Robert J. Schwartz Vickas Patel Ethan David Cohen Edward E. Morrisey 《Developmental cell》2010,18(2):275-287
Highlights? Wnt2 is required for atrial and inflow tract morphogenesis ? Wnt2 regulates expansion of secondary heart field progenitors ? Defects in Wnt2?/? mutants can be rescued using Wnt signaling agonists ? Wnt2 cooperates with Gata6 to regulate cardiac inflow tract development 相似文献
8.
Dustin E. Bosch Adam J. Kimple Alyssa J. Manning Robin E. Muller Francis S. Willard Mischa Machius Stephen L. Rogers David P. Siderovski 《Structure (London, England : 1993)》2013,21(1):65-75
Highlights? E. histolytica expresses a convergently evolved RGS-RhoGEF protein ? EhRGS-RhoGEF possesses a conventional nine-helix RGS domain ? Activated EhRGS-RhoGEF induces S2 cell spreading through Rac1/2 ? EhRGS-RhoGEF modulates amoebic migration and host cell killing 相似文献
9.
Manik C. Ghosh De-Liang Zhang Suh Young Jeong Gennadiy Kovtunovych Hayden Ollivierre-Wilson Audrey Noguchi Tiffany Tu Thomas Senecal Gabrielle Robinson Daniel R. Crooks Wing-Hang Tong Kavitha Ramaswamy Anamika Singh Brian B. Graham Rubin M. Tuder Zu-Xi Yu Michael Eckhaus Jaekwon Lee Tracey A. Rouault 《Cell metabolism》2013,17(2):271-281
Highlights? Irp1 deficiency causes polycythemia and pulmonary hypertension ? Irp1 regulates HIF2α translation and expression of EPO and endothelin 1 ? Irp1 represses erythropoiesis to protect tissue iron levels during iron deficiency ? A low-iron diet worsens polycythemia and causes sudden death in Irp1?/? animals 相似文献
10.
Highlights? Bacteriophytochrome structure containing photosensory and output transducing domain ? RpBphP1 binds to the cognate repressor RpPpsR2 on illumination with far-red light ? HOS domain is distantly related to Dhp and is essential for binding to the repressor ? Light-induced protomer swapping mechanism between dimers 相似文献
11.
Lipeng Wu Shirley Y. Lee Bo Zhou Uyen T.T. Nguyen Tom W. Muir Song Tan Yali Dou 《Molecular cell》2013,49(6):1108-1120
Highlights? ASH2L WH motif is important for trans-regulation of H3 K4 methylation by H2Bub ? Ub stimulates MLL activity in trans, in contrast to DOT1L regulation by H2Bub ? H2Bub enhances MLL, but not MLL3, methyltransferase activity ? H2Aub directly represses MLL methyltransferase activity 相似文献
12.
Sophie Herszterg Andrea Leibfried Floris Bosveld Charlotte Martin Yohanns Bellaiche 《Developmental cell》2013,24(3):256-270
Highlights? During cytokinesis, neighboring cells accumulate MyoII at the edges of the furrow ? MyoII nonautonomously sets the initial geometry of the daughter cell interface ? Neighboring membranes impede adherens junction (AJ) formation until a midbody forms ? Arp2/3-dependent actin accumulation in the dividing cell maintains AJ geometry 相似文献
13.
Bone marrow-derived cell therapy stimulates endogenous cardiomyocyte progenitors and promotes cardiac repair 总被引:1,自引:0,他引:1
Highlights? c-kit+ cell therapy stimulates endogenous cardiomyocyte progenitors ? Nkx2.5- and Gata4-expressing progenitors increase in the infarct border zone ? c-kit+ cell therapy leads to improved cardiac function ? No evidence for cardiomyocyte transdifferentiation by bone marrow progenitors 相似文献
14.
De Rybel B Vassileva V Parizot B Demeulenaere M Grunewald W Audenaert D Van Campenhout J Overvoorde P Jansen L Vanneste S Möller B Wilson M Holman T Van Isterdael G Brunoud G Vuylsteke M Vernoux T De Veylder L Inzé D Weijers D Bennett MJ Beeckman T 《Current biology : CB》2010,20(19):1697-1706
Highlights? GATA23 is involved in lateral root founder cell specification ? A coordinated migration of pericycle nuclei precedes the first asymmetric division ? An Aux/IAA28-dependent auxin signaling cascade controls GATA23 expression 相似文献
15.
Tetsuaki Ishikawa Fumie Itoh Sayumi Yoshida Shinobu Saijo Tetsuhiro Matsuzawa Tohru Gonoi Takashi Saito Yoshio Okawa Nobuyuki Shibata Tomofumi Miyamoto Sho Yamasaki 《Cell host & microbe》2013,13(4):477-488
Highlights? Mincle and Dectin-2 cooperatively recognize Malassezia through distinct ligands ? The Mincle ligands in Malassezia are glucosyl- and mannosylglycolipids ? The Dectin-2 ligand in Malassezia is an O-linked mannobiose-rich glycoprotein ? Cytokine response to the respective ligands was impaired in Mincle?/? and Dectin-2?/? DCs 相似文献
16.
Masashi Yamaji Jun Ueda Katsuhiko Hayashi Hiroshi Ohta Yukihiro Yabuta Kazuki Kurimoto Ryuichiro Nakato Yasuhiro Yamada Katsuhiko Shirahige Mitinori Saitou 《Cell Stem Cell》2013,12(3):368-382
Highlights? Prdm14 expression is important for maintenance of naive pluripotency ? PRDM14 antagonizes FGFR signaling and activates Akt-mTORC1 signaling ? PRDM14 represses de novo DNA methyltransferase expression ? This regulatory input is mediated through recruitment of PRC2 相似文献
17.
Stelter M Gutsche I Kapp U Bazin A Bajic G Goret G Jamin M Timmins J Terradot L 《Structure (London, England : 1993)》2012,20(3):554-564
Highlights? Crystal structure of the ATPase domain of DnaB from Helicobacter pylori ? MALLS analysis shows that HpDnaB forms dodecamers ? EM reconstruction shows that HpDnaB forms head-to-head double hexamers 相似文献
18.
Highlights? Trachea-derived Dpp/Bmp is required for midgut homeostasis ? Dpp expressed in tracheal cells reach intestinal cells through visceral muscles ? Dpp signaling is activated in enterocytes (ECs) in the Drosophila adult midgut ? Dpp signaling stabilizes ECs to restrict intestinal stem cell proliferation 相似文献
19.
Zarse K Schmeisser S Groth M Priebe S Beuster G Kuhlow D Guthke R Platzer M Kahn CR Ristow M 《Cell metabolism》2012,15(4):451-465
Highlights? Acute impairment of daf-2 (insulin/IGF1) signaling causes a transient ROS signal ? Different antioxidants reduce daf-2-mediated life span extension by up to 60% ? Reduced daf-2 signaling impairs glucose uptake and promotes proline metabolism ? Nutritional supplementation with the amino acid L-proline extends life span 相似文献
20.
Kitagawa D Flückiger I Polanowska J Keller D Reboul J Gönczy P 《Developmental cell》2011,20(4):550-562
Highlights? PP2A phosphatase is essential for centriole formation in C. elegans ? PP2A subunits genetically and physically interact with the SAS-5/SAS-6 complex ? PP2A-mediated dephosphorylation of SAS-5 is required for SAS-5/SAS-6 centriolar targeting ? Human PP2A is required for HsSAS-6 centriolar targeting and centriole formation 相似文献