Mental illness from the perspective of theoretical neuroscience

Theoretical neuroscience, which characterizes neural mechanisms using mathematical and computational models, is highly relevant to central problems in the philosophy of psychiatry. These models can help to solve the explanation problem of causally connecting neural processes with the behaviors and experiences found in mental illnesses. Such explanations will also be useful for generating better classifications and treatments of psychiatric disorders. The result should help to eliminate concerns that mental illnesses such as depression and schizophrenia are not objectively real. A philosophical approach to mental illness based on neuroscience need not neglect the inherently social and historical nature of mental phenomena.     

The Development of External Means of Communicative Orientation

That human activity is mediated by signs is one of the key postulates of the cultural-historical theory of the development of the mind. The tools and sign systems mediating activity are becoming increasingly numerous and are in a continuous process of transformation and evolution. Accordingly, ways of transforming mental processes are also evolving. Specialists working in the mainstream of the sociohistorical approach analyze phenomena of "remediation," exploring their practical relevance for psychological diagnoses and correction (Cole, 1989).     

Mental health; a discussion of various program approaches used in California and the basic assumptions involved

The nation's Number One health problem, mental illness, compels careful reevaluation of past and current methods of attack. It also invites consideration of the ways and means of integrating preventive measures that emphasize the conservation of mental health with prophylactic efforts that stress the avoidance of mental illnesses.A REVIEW OF THE DEVELOPMENT OF BOTH LOCAL AND STATEWIDE MENTAL HEALTH PROGRAMS IN CALIFORNIA REVEALS THAT THREE FUNDAMENTALLY DIFFERENT APPROACHES HAVE BEEN USED: (1) The traditional approach which confines itself to the protection of society from the "insane" by the state, and to the treatment of those who are not legally insane through "private enterprise"; (2) the public health approach which seeks to minimize the causes and/or spread of selected types of psychiatric disorder regarded as mass phenomena; and (3) the sociological approach which stresses the importance of social factors both in the causation and in the rehabilitation of those mental conditions that are considered to be symptomatic of a "sick" society. An approach that combines the theoretical and practical implications of all three viewpoints offers some new solutions to the problems of (1) fitting mental health programs to populations; (2) financing; and (3) balancing preventive and clinical services. Mental illness is not a single disease-entity but a long list of distinctly different conditions. The causes and manifestations are multiple. Biological, psychological and social components in either mental health or mental illness cannot be dissociated in any attempt to understand and deal with so wide a range of illnesses and states of comparative health. Therefore, many professions and multiple public and private agencies are involved in planning, developing and administering a mental health program.     

The Unknown Role of Mental Health in Global Development

In this paper, the author contrasts the substantial impact of mental health problems on global disability with the limited attention and resources these problems receive. The author discusses possible reasons for the disparity: Compared to physical disorders, mental health problems are considered less important, perhaps due to lower priority of disorders that primarily cause dysfunction rather than mortality, and skepticism that mental disorders are treatable in low-resource countries. He argues that achieving improved global health and development requires addressing problems causing disability, particularly mental health problems among populations in which the common mental disorders are frequent due to deprivation, war, and disasters. The author contends that services addressing the common mental disorders could be made widely and relatively cheaply accessible if provided by non-professional workers at the community level.     

Toward the Problem of Stages in the Mental Development of Children

The problem of stages' in the mental development of the child is the fundamental problem of child psychology. Elaboration of this problem has important theoretical significance since it is by determining the stages of mental development and by discovering the patterns of transition from one stage to the next that psychology will eventually solve the problem of the motive forces of mental development. We contend that every conception of the motive forces of mental development must first be tested on the "proving grounds" of the theory of developmental stages.     

Mental Misrepresentation in Non-human Psychopathology

In this paper, we defend a representational approach to at least some kinds of non-human psychopathology. Mentally-ill non-human minds, in particular in delusions, obsessive-compulsive disorders and similar cognitive states, are traditionally understood in purely behavioral terms. In contrast, we argue that non-human mental psychopathology should be at least sometimes not only ascribed contentful mental representation but also understood as really having these states. To defend this view, we appeal to the interactivist account of mental representation, which is a kind of a constructive approach to meaning. We follow Mark Bickhard in assuming that only an organism – either human or non-human – capable of detecting its own misrepresentations is representational. However, under his autonomy-based account of biological function these minds are incapable of misrepresentations because these minds are, ex hypothesi, unable to detect error in such representations. To solve this problem, we argue that adding a historical dimension – as in Millikan’s view on mental representations – to Bickhard’s account of function makes mental misrepresentation of mentally-ill minds possible. Using Bickhard’s dynamic account of function, it is possible to explain why delusions and other mental disorders can be seen as locally functional. However, an etiological dimension can further explain why misrepresentations seem to be globally dysfunctional. Even if representational or biosemiotic hypotheses about non-human psychopathology are difficult to confirm empirically, we defend the view that they can enrich our understanding of the causes and development of such pathologies, and may constitute a new progressive research programme.     

精神障碍的神经电生理循证医学证据

寻找客观标记物是精神医学研究最重要的课题之一,近期融合了循证医学的神经电生理研究为此提供了重要的途径,并取得了较为可观的研究成果,然而现有的研究结果仍然存在较多争议,难以取得一致共识.本文全面总结和归纳了结合以元分析(meta-analysis)为代表的循证医学方法和以脑电图(electroencephalography)为代表的神经电生理技术的精神障碍相关脑电研究成果,将事件相关电位划分为早期和晚期成分,并结合定量EEG分析,从感知加工、认知控制、情绪反应和社会认知等不同认知过程出发,系统分析和评述了精神障碍患者及高危人群的神经认知功能异常情况.我们发现:精神分裂症患者存在从早期到晚期的各种感知、情感和社会认知方面的缺陷,注意缺陷/多动障碍(ADHD)患者存在从早期到晚期的认知控制缺陷,焦虑和强迫障碍患者则存在早期的认知控制缺陷,而孤独症谱系障碍(ASD)患者则存在早期的感知加工和社会认知缺陷.此外,反映注意资源分配和认知加工速度的P300异常特征跨越了多个诊断类型,这表明该脑电成分可能反映了精神障碍的一般性认知缺陷.未来研究可利用多中心大样本数据库探寻精神疾病的神经电生理客观标记物,并融合先进的多模态精神影像技术和机器学习等人工智能方法,进一步增强精神障碍生物标记物的可靠性和有效性.     

Quantum-like model of processing of information in the brain based on classical electromagnetic field

We propose a model of quantum-like (QL) processing of mental information. This model is based on quantum information theory. However, in contrast to models of "quantum physical brain" reducing mental activity (at least at the highest level) to quantum physical phenomena in the brain, our model matches well with the basic neuronal paradigm of the cognitive science. QL information processing is based (surprisingly) on classical electromagnetic signals induced by joint activity of neurons. This novel approach to quantum information is based on representation of quantum mechanics as a version of classical signal theory which was recently elaborated by the author. The brain uses the QL representation (QLR) for working with abstract concepts; concrete images are described by classical information theory. Two processes, classical and QL, are performed parallely. Moreover, information is actively transmitted from one representation to another. A QL concept given in our model by a density operator can generate a variety of concrete images given by temporal realizations of the corresponding (Gaussian) random signal. This signal has the covariance operator coinciding with the density operator encoding the abstract concept under consideration. The presence of various temporal scales in the brain plays the crucial role in creation of QLR in the brain. Moreover, in our model electromagnetic noise produced by neurons is a source of superstrong QL correlations between processes in different spatial domains in the brain; the binding problem is solved on the QL level, but with the aid of the classical background fluctuations.     

The Fiftieth Anniversary of Soviet Psychophysiology

It must be generally recognized today that areas "contiguous" to a particular science have great theoretical and practical importance, which arises during contact of various sciences in some important objective. This is particularly true with respect to such a complex research objective as the thinking human brain. We find the ancients already beginning to speculate about the question of the relation of the "soul" to the body and about which body organ has the closest relation to psychological activity. Gradually this question became more concrete and was broken down into a group of more particular problems on which many scholars have been working. The early "classical" psychophysiology was primarily concerned with study of the relation of the senses and perception to the physical properties of stimuli and to the anatomical-physiological apparatuses of the peripheral sense organs. Currently, the main emphasis is shifting more and more to a study of the central mechanisms of psychological processes. This fundamental shift in approach to the traditional "psychophysical" problem (now frequently referred to as the psychophysiological problem) first took place in the area of studying the mechanisms of association, and was subsequently spread over studies of perception, emotion, voluntary movements, cognitive processes, and, finally, individual psychological differences.     

Mental Rotation Performance in Male Soccer Players

It is the main goal of this study to investigate the visual-spatial cognition in male soccer players. Forty males (20 soccer players and 20 non-athletes) solved a chronometric mental rotation task with both cubed and embodied figures (human figures, body postures). The results confirm previous results that all participants had a lower mental rotation speed for cube figures compared to embodied figures and a higher error rate for cube figures, but only at angular disparities greater than 90°. It is a new finding that soccer–players showed a faster reaction time for embodied stimuli. Because rotation speed did not differ between soccer-players and non-athletes this finding cannot be attributed to the mental rotation process itself but instead to differences in one of the following processes which are involved in a mental rotation task: the encoding process, the maintanence of readiness, or the motor process. The results are discussed against the background of the influence on longterm physical activity on mental rotation and the context of embodied cognition.     

Mental Development and Self-Development of the Child from Birth to Age 6

This book by Nikolai Nikolaevich Podd'iakov, Academician of the Russian Academy of Education and the towering Russian psychologist of preschool childhood, sets forth a new understanding of mental development in preschool-age children and reveals the mechanisms of their investigative behavior.

The interrelation between clear and vague knowledge, experimental and play activity, and near and far horizons of child development are addressed in a fundamentally new way.

In the author's opinion, such an approach explains the tantalizing riddle: "What lies behind the extremely rapid development of children between birth and the age of six?"

The book is intended for psychologists, facilitators, kindergarten teachers and supervisors, teachers in higher education institutions and teachers' colleges, and senior education administrators.     

Mental motor imagery: a window into the representational stages of action

The physiological basis of mental states can be effectively studied by combining cognitive psychology with human neuroscience. Recent research has employed mental motor imagery in normal and brain-damaged subjects to decipher the content and the structure of covert processes preceding the execution of action. The mapping of brain activity during motor imagery discloses a pattern of activation similar to that of an executed action.     

Spatially Distributed Effects of Mental Exhaustion on Resting-State FMRI Networks

Brain activity during rest is spatially coherent over functional connectivity networks called resting-state networks. In resting-state functional magnetic resonance imaging, independent component analysis yields spatially distributed network representations reflecting distinct mental processes, such as intrinsic (default) or extrinsic (executive) attention, and sensory inhibition or excitation. These aspects can be related to different treatments or subjective experiences. Among these, exhaustion is a common psychological state induced by prolonged mental performance. Using repeated functional magnetic resonance imaging sessions and spatial independent component analysis, we explored the effect of several hours of sustained cognitive performances on the resting human brain. Resting-state functional magnetic resonance imaging was performed on the same healthy volunteers in two days, with and without, and before, during and after, an intensive psychological treatment (skill training and sustained practice with a flight simulator). After each scan, subjects rated their level of exhaustion and performed an N-back task to evaluate eventual decrease in cognitive performance. Spatial maps of selected resting-state network components were statistically evaluated across time points to detect possible changes induced by the sustained mental performance. The intensive treatment had a significant effect on exhaustion and effort ratings, but no effects on N-back performances. Significant changes in the most exhausted state were observed in the early visual processing and the anterior default mode networks (enhancement) and in the fronto-parietal executive networks (suppression), suggesting that mental exhaustion is associated with a more idling brain state and that internal attention processes are facilitated to the detriment of more extrinsic processes. The described application may inspire future indicators of the level of fatigue in the neural attention system.     

重大灾害中救援军人心理应激干预的原则与方法

军人作为一个特殊群体,要经常参与各种重大灾害的救援工作。这些重大灾害容易诱发部分军人产生异常心理应激反应,对军人个体心理和群体心理产生负面影响。本文主要分析了救援军人心理应激反应产生的原因、表现和发展过程,然后提出心理干预的原则和程序,最后重点探讨了心理干预的方法措施。     

重大灾害中救援军人心理应激干预的原则与方法

军人作为一个特殊群体,要经常参与各种重大灾害的救援工作。这些重大灾害容易诱发部分军人产生异常心理应激反应,对军人个体心理和群体心理产生负面影响。本文主要分析了救援军人心理应激反应产生的原因、表现和发展过程,然后提出心理干预的原则和程序,最后重点探讨了心理干预的方法措施。     

The Fragile X Mental Retardation Protein in Circadian Rhythmicity and Memory Consolidation

The control of new protein synthesis provides a means to locally regulate the availability of synaptic components necessary for dynamic neuronal processes. The fragile X mental retardation protein (FMRP), an RNA-binding translational regulator, is a key player mediating appropriate synaptic protein synthesis in response to neuronal activity levels. Loss of FMRP causes fragile X syndrome (FraX), the most commonly inherited form of mental retardation and autism spectrum disorders. FraX-associated translational dysregulation causes wide-ranging neurological deficits including severe impairments of biological rhythms, learning processes, and memory consolidation. Dysfunction in cytoskeletal regulation and synaptic scaffolding disrupts neuronal architecture and functional synaptic connectivity. The understanding of this devastating disease and the implementation of meaningful treatment strategies require a thorough exploration of the temporal and spatial requirements for FMRP in establishing and maintaining neural circuit function.     

Tomasello,Wittgenstein, and Vygotsky: The Problem of the Intermental

The subject of this article is the early mental development of children in the light of research by two classical scholars from the last century and several of our contemporaries. L.S. Vygotsky contended that before the higher mental functions are mastered by a child, they are in a state distributed between the child and an adult “as an intermental category.” However, he subsequently developed this productive notion in a very narrow sense, and the intermental was concretized as it was expressed in language. L. Wittgenstein persuasively showed that mastery of language is impossible without a practical “demonstration” of the meanings of words as part of “language games” within practical activities. At the same time, he argued that there could be no theory regarding this process. M. Tomasello, in works written already in this century, shows that “language games” are learned by the child long before mastering spoken language, based on gestures that in turn rely on joint intentions and joint attention—i.e. on the intermental in the sense in which one can interpret Vygotsky’s comments. The article clarifies the principal difficulties of exploring the topic of the intermental in psychology. A function distributed between an adult and a child cannot be objectified (it was an attempt to objectify that resulted in a narrowing of Vygotsky’s topic). Moreover, the interpretation of the intersubjective status of some forms of the psychic leads to the notion that any mental function remains intermental throughout one’s lifetime. In the view of the author of the article, such an interpretation is essential, but requires serious advances in the philosophical-methodological development of the subject under study.     

An Archetypal Mental Coding Process

This paper presents evidence for a psychological coding process that meets the criteria that define such processes in organic nature and culture. The recognition of these previously unknown encoding sequences is derived from the recent formulation of an adaptive mental module of the mind—the emotion processing mind—that has evolved to cope with traumatic events and the unique, language derived, explicit human awareness of personal mortality. The emergent awareness of death has served as a selection factor for the evolution of a two-system, emotion-processing mind, with conscious and unconscious components, an arrangement that allows for the invocation of conscious denial, which in turn has fostered the use of encoding when faced with death-related traumas. The paper offers several ways in which evolved mental adaptations have features that are shared with those that are biological. Many aspects of these mental adaptive efforts are comparable to attempts at defense that are carried out by the immune system. In addition, the adaptive approach has been the foundation for the discovery of laws of communication, and thus of the mind, that are on a parallel with those found through mathematical models drawn from Newtonian physics.     

A Multiple Case Study of Mental Health Interventions in Middle Income Countries: Considering the Science of Delivery

In the debate in global mental health about the most effective models for developing and scaling interventions, there have been calls for the development of a more robust literature regarding the "non-specific", science of delivery aspects of interventions that are locally, contextually, and culturally relevant. This study describes a rigorous, exploratory, qualitative examination of the key, non-specific intervention strategies of a diverse group of five internationally-recognized organizations addressing mental illness in middle income countries (MICs). A triangulated approach to inquiry was used with semi-structured interviews conducted with service recipients, service providers and leaders, and key community partners (N = 159). The interview focus was upon processes of implementation and operation. A grounded theory-informed analysis revealed cross cutting themes of: a holistic conceptualization of mental health problems, an intensive application of principles of leverage and creating the social, cultural, and policy “space” within which interventions could be applied and resourced. These findings aligned with key aspects of systems dynamic theory suggesting that it might be a helpful framework in future studies of mental health service implementation in MICs.     

心理意象加工的子系统的研究

目的:本文主要探索心理意象加工过程的子系统以及它们之间的相互关系。方法:实验设计了四种不同的二维心理意象任务:再现任务,分辨任务,旋转任务和空间任务,分别用来测量被试对整体图像信息的提取能力,细节意象能力,空间操作和空间认知等心理意象能力的不同方面。91名正常的大学本科生(77男,14女)参加了此次实验。结果:心理意象的整体再现和细节意象能力呈显著相关;空间旋转和空间认知能力呈显著相关;而其他能力之间无显著相关性。结论:实验结果表明心理意象加工过程主要分为相时独立的两个子系统,即对心理意象的再现和操作能力。