急性心肌梗塞（AMI）的溶栓治疗

本文回顾了ＡＭＩ溶栓治疗的发展及溶栓治疗原理,列举溶栓治疗的适应症和禁忌症,较详细介绍包括蝮蛇抗栓酶在内的６种溶栓药,对溶栓治疗时机的掌握、用药途径、联合用药,影响复通因素,不良反应的防治等问题作了叙述。     

静脉血栓的溶栓治疗综述

介绍静脉血栓的组成、治疗方法及溶栓药物.     

急性心肌梗塞溶栓治疗综述

综述了急性心肌梗塞形成的原因、临床特点、溶栓治疗的作用及目前常用的溶栓药物.     

急性心肌梗死溶栓治疗疗效分析

目的探讨溶栓治疗用于急性心肌梗死(AMI)的效果与安全性。方法 2005年1月~2014年1月我院收治的急性心肌梗死患者102例,其中溶栓治疗34例,常规治疗68例,并观察两组疗效。结果溶栓治疗组的死亡率明显低于非溶栓治疗组,差异有统计学意义(P0.05);6h内溶栓治疗死亡率为8%,超过6h溶栓治疗死亡率为33.3%,差异有统计学意义(P0.05)。结论溶栓治疗急性心肌梗死患者是有效、安全的,早期溶栓治疗可提高抢救成功率。     

急性脑梗死溶栓治疗的临床进展

脑梗死是一种常见的神经系统疾病,具有高发病率、高死亡率和高致残率的特点,给患者及家庭带来巨大的痛苦和经济负担,它已成为当代医学界重要的研究课题。脑梗死的治疗直接影响患者的预后,因此寻找最有效的治疗药物及方法是非常重要的。目前,在急性脑梗死溶栓治疗方面国内外已经开展了大量的实验研究,取得了良好的实验结果。本文就急性脑梗死溶栓治疗的时间窗、溶栓方法、溶栓药物及影响因素等方面进行了总结及展望。     

尿激酶静脉溶栓治疗急性心肌梗死的疗效观察--附35例报告

目的 观察尿激酶静脉溶栓治疗急性心肌梗死的疗效.方法将66例急性心肌梗塞住院患者随机分成两组,溶栓组35例在常规治疗的同时,用尿激酶静脉溶栓治疗,非溶栓组仅用常规治疗,两组进行比较分析.结果 溶栓组血管再通率74.3%,非溶栓组为25.81%,两组间有明显差异(P<0.05),住院4周的病死率,溶栓组为2.86%,非溶栓组为16.16%,两组间有显著差异(P<0.01).结论 尿激酶静脉溶栓能明显提高急性心肌梗死患者的血管再通率和抢救成功率,降低近期病死率.     

静脉溶栓治疗28例急性心肌梗死的临床观察

目的:探讨静脉溶栓治疗急性心肌梗死(AMI)的临床疗效。方法:通过回顾性分析2011年9月至2012年8月在我院住院治疗的28例AMI患者采用静脉溶栓治疗,即观察组;与常规治疗后溶栓的29例AMI进行对照,比较两组发病至溶栓的时间和疗效。结果:两组发病至溶栓的平均时间以及冠脉再通率均具有显著性差异(P<0.01)。结论:静脉溶栓治疗急性AMI不但能减少发病至溶栓的时间,而且还可以提高AMI溶栓后的冠脉再通率,是急性心肌梗死的一种有效治疗方法。     

急性脑梗死尿激酶静脉溶栓与DSA引导下超选择性动脉溶栓的疗效对比分析

目的 探讨尿激酶静脉溶栓与数字减影血管造影(DSA)引导下超选择性动脉溶栓的疗效及安全性. 方法 选取2015年7月～2020年5月我院收治的120例急性脑梗死患者为研究对象,随机分为研究组和对照组各60例.研究组行DSA检查后直接行尿激酶超选择性动脉溶栓,对照组行传统尿激酶静脉溶栓治疗.观察两组患者的疗效,比较两组患...     

下肢深静脉血栓形成的危险因素及导管接触性溶栓的临床疗效研究

目的:分析下肢深静脉血栓形成(DVT)的危险因素,并探讨导管接触性溶栓治疗下肢DVT的临床疗效。方法:选取2015年12月～2018年12月间在北京积水潭医院治疗的126例下肢DVT患者作为病例组,另外选取同期在我院健康体检的志愿者60例作为对照组,采用多因素Logistic回归分析下肢DVT的危险因素。将病例组按随机数表法分为系统溶栓组(采用系统性溶栓治疗)和导管溶栓组(采用导管接触性溶栓治疗)两个亚组,各63例。评价两组疗效,观察两组患者治疗前及治疗1个月后的双下肢周径差和静脉通畅度评分,记录并比较两组患者治疗时间、住院时间、尿激酶用量以及不良反应发生情况。结果:病例组与对照组年龄、体质量指数(BMI)、红细胞计数(RBC)、手术外伤史比较,差异有统计学意义(P0.05)。多因素Logistic回归分析结果显示,年龄、BMI、RBC、手术外伤史均是下肢DVT的独立危险因素(P0.05)。导管溶栓组痊愈率为57.14%(36/63),高于系统溶栓组的33.33%(21/63)(P0.05);治疗1个月后,两组双侧大腿周径差、双侧小腿周径差以及静脉通畅度评分均明显减小,且导管溶栓组上述指标均明显小于系统溶栓组(P0.05)。导管溶栓组治疗时间和尿激酶用量明显少于系统溶栓组,但住院时间明显长于系统溶栓组(P0.05)。两组患者不良反应发生率比较差异无统计学意义(P0.05)。结论:年龄、BMI、RBC、手术外伤史均是下肢DVT的独立危险因素,导管接触性溶栓治疗下肢DVT的疗效显著,具有较好的安全性。     

急性缺血性中风早期中小剂量溶栓治疗的初步研究

目的 研究用中、小剂量尿激酶（UK）溶栓治疗急性缺血性中风的临床效果,寻找一个安全的适合静脉溶栓的UK剂量和方法。方法 净急性缺血性中风患者分为两组：溶栓组18例,中小剂量UK溶栓,视病情变化予以追加。常规治疗组（对照组）12例,除不用UK外,其它治疗措施相同。每例患者于治疗前后进行欧洲卒中量表（ESS）评分,以评价疗效。结果 溶栓组溶栓后2h、6h、1天、2天、3天、7天和14天的ESS评分均比溶栓前升高,无并发出血现象,溶栓组治疗后第1天、第2天、第3天、第7天和第14天ESS评分与治疗前ESS评分的差值明显高于常规治疗组治疗后第1天、第2天、第3天、第7天和第14天ESS评分与治疗前ESS评分的差值。结论 用中小剂量UK溶栓,实行剂量个体化,效果较好,且副作用小。     

Investigation of the mechanism of temperature sensitivity of the electroreceptors of ampullae of lorenzini

In experiments on Black Sea skates (Raja clavata), the potential of the receptor epithelium of the ampullae of Lorenzini and spike activity of single nerve fibers connected to them were investigated during electrical and temperature stimulation. Usually the potential within the canal was between 0 and –2 mV, and the input resistance of the ampulla 250–400 k. Heating of the region of the receptor epithelium was accompanied by a negative wave of potential, an increase in input resistance, and inhibition of spike activity. With worsening of the animal's condition the transepithelial potential became positive (up to +10 mV) but the input resistance of the ampulla during stimulation with a positive current was nonlinear in some cases: a regenerative spike of positive polarity appeared in the channel. During heating, the spike response was sometimes reversed in sign. It is suggested that fluctuations of the transepithelial potential and spike responses to temperature stimulation reflect changes in the potential difference on the basal membrane of the receptor cells, which is described by a relationship of the Nernst's or Goldman's equation type.I. P. Pavlov Institute of Physiology, Academy of Sciences of the USSR, Leningrad. I. M. Sechenov, Institute of Evolutionary Physiology and Biochemistry, Academy of Sciences of the USSR, Leningrad. Pacific Institute of Oceanology, Far Eastern Scientific Center, Academy of Sciences of the USSR, Vladivostok. Translated from Neirofiziologiya, Vol. 12, No. 1, pp. 67–74, January–February, 1980.     

Determination of stoichiometry of radioiodination of proteins

A sensitive method for the detection of small quantities of hydrophobic antioxidant free radical scavengers such as butylatedhydroxytoluene (BHT) and butylatedhydroxyanisole (BHA) in aqueous samples is described. The procedure involves extraction of the hydrophobic free radical scavenger into an organic solvent phase, followed by the subsequent reaction of an aliquot of this extract with the stable cation radical tris(p-bromophenyl)amminium hexachloroantimonate (TBACA). In experiments with BHT and BHA, the loss of TBACA absorbance at 730 nm was found to be linearly proportional to the amount of antioxidant added, with quantities of BHT as small as 200 pmol being easily detectable. In aqueous suspensions of dimyristoylphosphatidylcholine vesicles, assays of the aqueous BHT concentration showed that BHT partitioned strongly into the membrane phase, achieving very high BHT/phospholipid ratios. For a given concentration of BHT, partitioning into the membrane phase was greater in large, multilamellar liposomes than in either small, single-walled vesicles or in purified rat brain synaptic vesicle membranes. Direct assay of BHT and BHA in phospholipid membranes, however, was complicated by a nonspecific interaction between TBACA and the phospholipid.