Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity

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Distinct Transcriptional Responses across Tissue-Resident Macrophages to Short-Term and Long-Term Metabolic Challenge

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Glycerate from intestinal fructose metabolism induces islet cell damage and glucose intolerance

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A mechanosensitive lipolytic factor in the bone marrow promotes osteogenesis and lymphopoiesis

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Disruption of Acetyl-Lysine Turnover in Muscle Mitochondria Promotes Insulin Resistance and Redox Stress without Overt Respiratory Dysfunction

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Autonomous sensing of the insulin peptide by an olfactory G protein-coupled receptor modulates glucose metabolism

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Western diet induces Paneth cell defects through microbiome alterations and farnesoid X receptor and type I interferon activation

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A Mouse Homolog of a Human TP53 Germline Mutation Reveals a Lipolytic Activity of p53

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TOX4, an insulin receptor-independent regulator of hepatic glucose production,is activated in diabetic liver

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Spatial mapping reveals human adipocyte subpopulations with distinct sensitivities to insulin

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Tumor-derived MMPs regulate cachexia in a Drosophila cancer model

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Conversion of the death inhibitor ARC to a killer activates pancreatic β cell death in diabetes

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Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA

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Sugar-Induced Obesity and Insulin Resistance Are Uncoupled from Shortened Survival in Drosophila

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Distinct properties of adipose stem cell subpopulations determine fat depot-specific characteristics

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Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state

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Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition

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Pimozide Alleviates Hyperglycemia in Diet-Induced Obesity by Inhibiting Skeletal Muscle Ketone Oxidation

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BefA,a microbiota-secreted membrane disrupter,disseminates to the pancreas and increases β cell mass

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Roseburia spp. Abundance Associates with Alcohol Consumption in Humans and Its Administration Ameliorates Alcoholic Fatty Liver in Mice

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