共查询到20条相似文献,搜索用时 31 毫秒
1.
Giuseppe Savona Maurizio Bruno Franco Piozzi Orietta Servettaz Benjamín Rodríguez 《Phytochemistry》1984,23(4):849-852
From the aerial part of Teucrium massiliense three new neo-clerodane diterpenoids, deacetylajugarin-II, teumassilin and 6,19-diacetylteumassilin, have been isolated, besides the previously known diterpenes montanin C and teucjaponin A. The structures of deacetylajugarin-II (4α,18-epoxy-6α,19-dihydroxy-neo-clerodan-13-en-15,16-olide), teumassilin (4α,18:15,16-diepoxy-6α,12S,19-trihydroxy-neo-cleroda-13(16),14-diene) and 6,19-diacetylteumassilin (6α,19-diacetoxy-4α,18:15,16-diepoxy-12S-hydroxy-neo-cleroda-13(16),14-diene) were established by chemical and spectroscopic means. In addition, the previously known flavones salvigenin and cirsimaritin have also been obtained from the same source. 相似文献
2.
Essam Abdel Sattar Jaber S. Mossa Ilias Muhammad Farouk S. El-Feraly 《Phytochemistry》1995,40(6):1737-1741
The aerial parts of Teucrium yemense yielded four new neo-clerodane diterpenoids, namely, 6β-O-acetyl-3β-hydroxyteucroxylepin, teucryemin, 19-O-acetylteucryemin and teucryeminone, in addition to the known flavone cirsiliol. The structures of the new compounds were elucidated from their spectral data, by chemical derivatization and by comparison with closely related compounds. 相似文献
3.
María C. García-Alvarez José L. Marco Benjamín Rodríguez Giuseppe Savona Franco Piozzi 《Phytochemistry》1982,21(10):2559-2562
From the aerial part of Teucrium pyrenaicum three new neo-clerodane diterpenoids have been isolated. Their structures, 3β-acetoxy-4α,18:12S,2OS: 15,16:19, 2OS-tetraepoxy-neo-cleroda-13(16),14-dien-6-one (teupyrenone), 3β,6α,19-triacetoxy- 4α,18:15,16-diepoxy-neo-cleroda-13(16),14-dien-20,12S-olide (teupyreinin), and 3β, 6α,19,2OS-tetra-acetoxy-4α,18:12S,2OS: 15,16-triepoxy-neo-cleroda-13(16), 14-diene (teupyreinidin), were established mainly by spectroscopic means. 相似文献
4.
Giuseppe Savona Franco Piozzi Orietta Servettaz Francisco Fernández-Gadea Benjamín Rodríguez 《Phytochemistry》1984,23(3):611-613
A new neo-clerodane diterpenoid, teumarin, was isolated from the aerial part of Teucrium marum. Its structure, 19-acetoxy-4α,18:15,16-diepoxy-2β,6β-dihydroxy-neo-cleroda-13(16),14-dien-20,12S-olide, was established by chemical and spectroscopic means and by comparison with closely related compounds. 相似文献
5.
Antialgal furano-diterpenes from Potamogeton natans L 总被引:3,自引:0,他引:3
DellaGreca M Fiorentino A Isidori M Monaco P Temussi F Zarrelli A 《Phytochemistry》2001,58(2):299-304
Six furano-ent-labdanes, 19-acetoxy-15,16-epoxy-8(17),13(16),14-ent-labdatrien-20-al, 15,16-epoxy-12-oxo-8(17),13(16),14-ent-labdatrien-20,19-olide, 12(S)-hydroxy-15,16-epoxy-8(17),13(16),14-ent-labdatrien-20,19-olide, 10alpha,19-dihydroxy-15,16-epoxy-8(17),13(16),14-nor-ent-labdatriene, 19,20-dihydroxy-15,16-epoxy-8(17),13(16),14-ent-labdatriene, 15,16-epoxy-12-oxo-8(17),13(16),14-ent-labdatrien-19,20-olide, were isolated, together with the known potamogetonin, from the aquatic plant Potamogeton natans. Their structures were determined on the basis of their chemical and spectral data. The compounds showed in vitro phytotoxicity against Raphidocelis subcapitata, a microalga used in aquatic tests. 相似文献
6.
Peter Y. Malakov Georgy Y. Papanov Marí a C. De La Torre Benjamí n Rodrí guez 《Phytochemistry》1991,30(12):4083-4085
Three new neo-clerodane diterpenoids, ajugavensins A–C, have been isolated from the acetone extract of the aerial parts of Ajuga genevensis and their structures established by spectroscopic means and by comparison with closely related compounds. 相似文献
7.
Zakaria Cheikh-Ali Timothée Okpekon François Roblot Christian Bories Matthieu Cardao Jean-Christophe Jullian Erwan Poupon Pierre Champy 《Phytochemistry letters》2011,4(3):240-244
Two novel labdane diterpenoids, 15ξ-methoxy-labdan-8(17),11(E),13(14)-trien-15,16-olide (1) and 12(S)-hydroxy-15ξ-methoxy-labdan-8(17),13(14)-dien-15,16-olide (2) were isolated from the rhizomes of Aframomum sceptrum K. Schum (Zingiberaceae). Their structures were established on the basis of their spectroscopic data. Stigmast-4-en-6β-ol-3-one and caryophylene oxide were also obtained. In vitro trypanocidal and leishmanicidal activities of labdanes 1 and 2 were evaluated. Compound 2 exhibited activity similar to that of reference drugs against Leishmania donovani. 相似文献
8.
Francisco Férnandez-Gadea Benjamín Rodríguez Giuseppe Savona Franco Piozzi 《Phytochemistry》1984,23(5):1113-1118
From the aerial part of Teucrium lanigerum two new neo-clerodane diterpenoids, 20-deacetyleriocephalin and isoeriocephalin, have been isolated, together with the previously known diterpene eriocephalin. The structures of 20-deacetyleriocephalin [19-acetoxy 4α,18:15,16-diepoxy-7α-hydroxy-6-keto-neo-cleroda-13(16),14-diene-20S,12S-hemiacetal] and isoeriocephalin [19-acetoxy-4α,18:15,16-diepoxy-6α-hydroxy-7-keto-neo-cleroda-13(16),14-diene (20-acetyl)-20S,12S-hemiacetal] were established by chemical and spectroscopic means and by correlation with known compounds. 相似文献
9.
Eleven ent-clerodanes, 13-hydroxy-cis-ent-cleroda-3,14-diene, 15-hydroxy-cis-ent-cleroda-3,13(E)-diene, 1beta,12:15,16-diepoxy-cis-ent-cleroda-13(16),14-dien-18alpha,6alpha-olide, 8beta,12:15, 16-diepoxy-cis-ent-cleroda-13(16),14-dien-18alpha,6alpha-olide, 1beta,16:15,16-diepoxy-cis-ent-cleroda-12,14-dien-18alpha,6alpha-olide, 7beta,12:8beta,12-diepoxy-15-hydroxy-cis-ent-cleroda-13-en-16,15:18alpha,6alpha-diolide, 7beta,12:8beta,12-diepoxy-16-hydroxy-cis-ent-cleroda-13-en-15,16:18alpha,6alpha-diolide, 1alpha-acetoxy-8beta,12-epoxy-15-hydroxy-cis-ent-cleroda-13-en-16,15:18alpha,6alpha-diolide, 1beta,12-epoxy-16-hydroxy-cis-ent-cleroda-13-en-15,16:18alpha,6alpha-diolide, 8beta,12-epoxy-15-hydroxy-trans-cleroda-13-en-16,15:18alpha,6alpha-diolide, 8beta,12-epoxy-16-hydroxy-trans-cleroda-13-en-15,16:18alpha,6alpha-diolide along with the known clerodane diterpenes anastreptin and orcadensin have been isolated from the liverwort Adelanthus lindenbergianus (Lehm.) Mitt. Furthermore, three eudesmane sesquiterpenes together with the known (-)-1beta,10-epoxyaristolan, 3,4-seco-4(23),20(29)-lupadien-3,28-dicarboxylic acid dimethyl ester and two acetophenone derivatives were identified by spectroscopic methods, essentially MS and NMR experiments. 相似文献
10.
The structures of two new diterpenoids, galeopsin and pregaleopsin, isolated from aerial parts of Galeopsis angustifolia (Labiatae) have been shown to be 8β-acetoxy-15,16-epoxy-9α-hydroxylabda-13(16),14-dien-7-one and 8β-acetoxy-9α,13R; 15,16-diepoxylabd-14-en-7-one, respectively, by chemical and spectroscopic studies. The previously known diterpenoid hispanolone (15,16-epoxy-9α-hydroxy-8α-labda-13(16),14-dien-7-one) has been also obtained from the same source. A thermal retroaldol reaction in the absence of solvent experienced by these 9-hydroxy-7-keto-labdanes is also described. 相似文献
11.
采用正相硅胶、MCI、反相RP-18和半制备液相等色谱技术,对柏科翠柏属植物翠柏(Calocedrus macrolepis)中的二萜类成分及其抗炎活性进行了研究。结果表明:从中共分离得到8个二萜类化合物,分别鉴定为8-hydroxy-labda-13(16),14-dien-19-yl trans-coumarate(1)、trans-communal(2)、trans-communic acid(3)、pinusolidic acid(4)、isocupressic acid(5)、fokihodgin F(6)、acetylisocupressic acid(7)、15,16-dihydroxy-labda-8(17),13(E)-dien-19-oic acid(8)。化合物1~8均为首次从该植物中分离得到。化合物7对LPS诱导的RAW264.7巨噬细胞释放NO具有显著的抑制作用,其IC50值为9.31μmol·L~(-1)。 相似文献
12.
From the aerial parts of Teucrium scordium a new neo-clerodane diterpenoid, 2-keto-19-hydroxyteuscordin, has been isolated, besides the previously known diterpenoids teucrin E and teucrin H4. The structure of 2-keto-19-hydroxyteuscordin, (12S)-15,16-epoxy-2-keto-19-hydroxy neo-clerodane-13(16),14-dien-18β,6β:20,12-diolide, was established by chemical and spectroscopic means. 相似文献
13.
A new neo-clerodane diterpenoid, teuchamaedrin C, has been isolated from the aerial parts of Teucrium chamaedrys. Its structure, (12S,18S)-15,16-epoxy-neo-clerodane-13(16)14-dien-19,20-olide-18,6β-hemiacetal, was established by spectroscopic and chemical means. In addition, the previously known diterpenoids 6α-hydroxyteuscordin and dihydroteugin were isolated from the same source. 相似文献
14.
Haba H Lavaud C Harkat H Alabdul Magid A Marcourt L Benkhaled M 《Phytochemistry》2007,68(9):1255-1260
Two new compounds with tigliane and cycloartane skeletons: 4,12-dideoxy(4alpha)phorbol-13-hexadecanoate (1) and 24-methylenecycloartane-3,28-diol (2), respectively, in addition of four known diterpenoids and 13 triterpenoids: 3-benzoyloxy-5,15-diacetoxy-9,14-dioxojatropha-6(17),11-diene (4), ent-abieta-8(14),13(15)-dien-16,12-olide (5), ent-8alpha,14alpha-epoxyabieta-11,13(15)-dien-16,12-olide (6), ent-3-hydroxyatis-16(17)-ene-2,14-dione (7), 3beta-hydroxytaraxer-14-en-28-oic acid (8), beta-sitosteryl-3beta-glucopyranoside-6'-O-palmitate (9), multiflorenyl acetate (10), multiflorenyl palmitate (11), peplusol (12), 24-methylenecycloartanol (3), lanosterol (13), euferol (14), butyrospermol (15), cycloartenol (16), obtusifoliol (17), cycloeucalenol (18) and beta-sitosterol (19), were isolated from the roots of Euphorbia guyoniana. Their structures were established on the basis of physical and spectroscopic analysis, including 1D and 2D homo- and heteronuclear NMR experiments (COSY, HSQC, HMBC and NOESY) and by comparison with the literature data. 相似文献
15.
Diterpenes from Alomia myriadenia (Asteraceae) with cytotoxic and trypanocidal activity 总被引:1,自引:0,他引:1
Scio E Ribeiro A Alves TM Romanha AJ Dias de Souza Filho J Cordell GA Zani CL 《Phytochemistry》2003,64(6):1125-1131
Further investigation of the aerial parts of Alomia myriadenia revealed an halimane diterpene identified as ent-8S,12S-epoxy-7R,16-dihydroxyhalima-5(10),13-dien-15,16-olide along with the known ent-16-hydroxylabda-7,13-dien-15,16-olide, ent-12R-hydroxylabda-7,13-dien-15,16-olide, 6,7-methylenedioxycoumarin (ayapin), and kaempferol-7-methylether (rhamnocitrin). Evaluated in a panel of human cancer cell lines, the 16-hydroxylabade diterpene was the most active, showing an ED(50) value of 0.3 mug/ml against Lu1 (human lung cancer) cells. Tested in vitro against Trypanosoma cruzi in infected murine blood, this compound caused lysis of 100% of the parasites at 250 mug/ml. 相似文献
16.
Giuseppe Savona Franco Piozzi Orietta Servettaz Benjamín Rodríguez Francisco Fernández-Gadea Manuel Martín-Lomas 《Phytochemistry》1984,23(4):843-848
From the aerial part of Teucrium flavum subsp. glaucum a new neo-clerodane diterpenoid, teuflavin, and a new 19-nor-neo-clerodane glucoside, teuflavoside, have been isolated, besides the previously known diterpene teuflin. The structures of teuflavin (19-acetoxy-4α,18:15,16-diepoxy-6β-hydroxy-3-keto-neo-cleroda-13(16),14-diene-20,ξ,12S-hemiacetal) and teuflavoside (18-acetoxy-15,16-epoxy-19-nor-neo-cleroda-4,13(16),14-trien-20,12S-olid-6β-yl-2′-O-acetyl-β-d-glucopyranoside) were established by chemical and spectroscopic means and by correlation with known compounds. In addition, the previously known flavone salvigenin has also been obtained from the same source. 相似文献
17.
Ayhan Ulubelen Nezhun Gören Ferdinand Bohlmann Jasmin Jakupovic Michael Grenz Nevin Tanker 《Phytochemistry》1985,24(6):1305-1308
In addition to previously obtained furanosesquiterpenes, two new eudesmanolides and a new glechomanolide were isolated from the fruits of Smyrnium cordifolium, while the roots gave two new eudesmanolides. The new compounds from the fruits were 1β-acetoxy-eudesman-4(15), 7(11)-dien-8,12-olide, 1β-acetoxy-8β-hydroxy-eudesman-4(15),7(11)-dien-8,12-olide, 1β,10α;4α,5β-diepoxy-8-hydroxy-glechomanolide, those obtained from the roots were smyrnicordiolide and the corresponding 8β-hydroxy derivative belonging to a new type of oxepine derivative. 相似文献
18.
Three labdane diterpenes 15,16-epoxy-6-hydroxylabda-5,8,13(16),14-tretraen-7-one (leojaponin), (9alpha,13S);15,16-diepoxy-7beta-hydroxylabd-14-en-6-one (13-epi-preleoheterin), and (9alpha,13R);15,16-diepoxy-6beta-hydroxylabd-14-en-7-one (iso-preleoheterin) were isolated from the leaves of Leonurus japonicus, in addition to the previously reported preleoheterin. The structure elucidations were made based on analysis of their spectroscopic data. 相似文献
19.
20.
Otilia D. L. Pessoa Telma L. G. De Lemos M rio G. De Carvalho Raimundo Braz-Filho 《Phytochemistry》1995,40(6):1777-1786
Further cordiachromes, rel-10,11β-epoxy-11-ethoxy-8-hydroxy-2-methoxy-8aβ-methyl-5,6,7,8,8a,9,10aβ-octahydro-1,4-anthracendione, 6-formyl-2-methoxy-9-methyl-7,8-dihydro-1,4-phenanthrendione, rel-8,11;9,11-diepoxy-1,4-dihydroxy-2-methoxy-8aβ-methyl-5,6,7,8,8a,9,10,10aβ-octahydro-10-anthracenone, rel-9,11-epoxy-1,4,8-trihydroxy-2-methoxy-8aβ-methyl-5,6,7,8,8a,9,10,10aβ-octahydro-10-anthracenone, rel-2″-methoxy-7″-methyl-1″,4″-naphtalendione-(6″→5)-tetrahydropyran-(2-eq→O→2ax)-tetrahydropyran-(5′→6)- 2-methoxy-7-methyl-1,4-naphthalendione, together with the known, allantoin, sitosterol and 3β-O-d-glucopyranosylsitosterol, have been isolated from Auxemma oncocalyx. Their structures were determined from spectral data, including 2D NMR experiments. 相似文献