共查询到20条相似文献，搜索用时 15 毫秒
1.
Marta Inglés Lucia Gimeno-Mallench Cristina Mas-Bargues Mar Dromant Raquel Cruz-Guerrero Francisco José García-García Leocadio Rodríguez-Mañas Juan Gambini Consuelo Borrás José Viña 《Revista espa?ola de geriatría y gerontología》2018,53(4):202-207
Introduction
The search for biomarkers that can lead to the early diagnosis and thus, early treatment of frailty, has become one of the main challenges facing the geriatric scientific community. The aim of the present study was to identify single nucleotide polymorphisms (SNPs) related to frailty.Material and methods
The study was conducted on 152 subjects from the Toledo Study for Healthy Aging (65 to 95 years of age), and classified as frail (n=78), and non-frail (n=74), according to Fried's criteria. After blood collection, DNA was isolated and amplified for the analysis of SNPs using AxiomTM Genotyping technology (Affymetrix). Statistical analyses were performed using the Plink program and library SNPassoc.Results
The results of the study showed 15 SNPs with a P < .001. Those SNPs involved in processes related to frailty, such as energy metabolism, regulation of biological processes, cell motility and integrity, and cognition are highlighted.Conclusions
These results suggest that the genetic variations identified in frail individuals that are involved in biological processes related to frailty may be considered as biomarkers for the early detection of frailty. 相似文献2.
3.
José F. Parodi Wendy Nieto-Gutierrez Walter A. Tellez Iris Ventocilla-Gonzales Fernando M. Runzer-Colmenares Alvaro Taype-Rondan 《Revista espa?ola de geriatría y gerontología》2018,53(2):73-76
Introduction
The prevention and management of neurocognitive disorders (NCD) among older adults can be improved by early identification of risk factors such as walking speed. The objective of the study is to assess the association between gait speed and NCD onset in a population of Peruvian older adults.Material and methods
Cohort conducted in older adults who attended the geriatrics service of Naval Medical Center (Callao, Peru). During the baseline assessment, participants’ gait speed was recorded. Subsequently, participants were followed-up annually for 5 years, with a mean of 21 months. NCD onset was defined as the occurrence of a score ≤ 24 points on the Mini Mental State Examination (screening test) during follow-up. The hazard ratios (HR) and their 95% confidence intervals (95% CI) were calculated using Cox regression.Results
The study included 657 participants, with a mean age of 73.4 ± 9.2 (SD) years, of whom 47.0% were male, 47.8% had a gait speed < 0.8 m/s, and 20.1% developed NCD during the follow up. It was found that older adults who had gait speed < 0.8 m/s at baseline were more likely to develop NCD than those who had a gait speed ≥ 0.8 m/s (adjusted HR = 1.41, 95% CI = 1.34-1.47).Conclusion
A longitudinal association was found between decreased gait speed and NCD onset, suggesting that gait speed could be useful to identify patients at risk of NCD onset. 相似文献4.
Ana Cristina Gracia-Rebled Javier Santabárbara Raul Lopez-Anton Concepción Tomas Elena Lobo Guillermo Marcos Antonio Lobo 《Revista espa?ola de geriatría y gerontología》2018,53(3):134-140
Introduction
The prevalence of cognitive impairment with no dementia (CIND) varies between 5.1% and 35.9%, increasing between 65 and 85 years. The CIND increases the risk of dementia. Factors such as education, occupation, and social activities are associated with the risk of cognitive impairment. The main objective of this study was to analyse the association between the main occupation developed throughout life and CIND in a general population sample of over 55 years.Methods
In wave I of the ZARADEMP Project, a sample (n = 4803) of people over 55 years was interviewed. CIND measurement was obtained through the Mini Mental State Examination. Occupational activity data were recoded into white collar, blue collar, homemakers, and farmers. The association between the occupation variables and CIND was estimated using the odds ratio, and 95% confidence intervals using logistic regression equations.Results
The prevalence of CIND in the sample was 28.2%. As regards white collar workers, the CIND diagnosis odds was 53% higher for blue collar workers, 77% higher for women who were homemakers and almost twice for farmers, after controlling for socio-demographic, behavioural and clinical variables. All results were statistically significant.Conclusions
CIND frequency is influenced by the previous occupation of the subjects. An occupation with higher intellectual requirements can help keep cognitive functions intact for longer. 相似文献5.
Vanessa Blanco María Adelina Guisande María Teresa Sánchez Patricia Otero Lara López Fernando Lino Vázquez 《Revista espa?ola de geriatría y gerontología》2019,54(1):19-26
Introduction
Most of existing work on burden among family caregivers has methodological sample constraints. Moreover, there is contradictory information regarding sociodemographic variables, especially those related to care, clinical variables, and burden. Few studies have analysed the self-esteem and personality characteristics as correlates of burden. In this study, an analysis is performed on the prevalence of burden among family caregivers and the relationship with their sociodemographic, care-related, and clinical characteristics.Materials and methods
The study consisted of a randomly selected sample of 294 family caregivers (mean age 55.3 years, 89.8% women) from the Autonomous Region of Galicia, Spain. Trained psychologists assessed the presence of burden via the Zarit Caregiver Burden Interview (CBI). Information was also collected on sociodemographic, care-related variables, social support, personality characteristics, and self-esteem.Results
More than half (55.4%) of the surveyed caregivers exhibited burden (CBI > 24), with mean score of 27.3 (SD = 13.3). Not being employed outside the home and having higher scores in neuroticism were associated with a greater probability of presenting with burden, while being older and having higher social support were associated with a lower risk.Conclusions
A significant number of caregivers suffered from burden in the current study. Psychotherapeutic interventions need to be developed for those who are already suffering from burden, as well as prevention strategies for those who have not yet developed it. 相似文献6.
Debora Moral-Cuesta Isabel Rodríguez-Sánchez Rocío Menéndez-Colino Jesús Díaz-Sebastián Teresa Alarcón Isabel Martín Maestre Juan Ignacio González-Montalvo 《Revista espa?ola de geriatría y gerontología》2018,53(2):81-84
Introduction
The prevalence of pelvic fracture (PF) due to frailty is increasing, leading to an increase in functional impairment in the patient, as well as increasing morbidity and mortality. The aim of the present study is to gain knowledge about the sociodemographic characteristics, as well as the functional features, of patients admitted to hospital with PF and evaluated by a Geriatrics department. The functional burden of PF and the potential influence of geriatric interventions are also assessed.Material and methods
A retrospective study conducted between 1995 and 2015 on all patients older than 65 years old with PF admitted to the Traumatology department, and then assessed in the Geriatrics Department. Sociodemographic information was also collected (age, gender and place of residence), as well as data from the geriatric assessment (baseline situation and at hospital admission), hospital stay, within hospital mortality, and discharge.Results
The study included 271 patients with a mean age of 81.1 ± 7 years, and mainly women (81.2%). The median hospital stay was 9 days (interquartile range 5 to 14 days). The ability to walk independently decreased after PF from 72.3% to 3.6%. Severe disability cases increased in activities of daily living from 7.9% to 79.5%. Within hospital mortality was 2.2%. As regards medical follow-up consultations, the mean length of stay was significantly reduced compared to the assessment consultations (10.0 ± 7.8 vs 16.1 ± 12.0 days, P<.001)Conclusion
PF patients evaluated by the Geriatrics Department were mainly women, with advanced age, and a severe functional impairment secondary to PF. The intervention of a geriatrician could contribute to optimise hospital resources. 相似文献7.
Cristina Buiza Javier Yanguas Amaia Zulaica Iván Antón Enrique Arriola Alvaro García 《Revista espa?ola de geriatría y gerontología》2018,53(4):208-212
Introduction
Adaptation and validation to the Basque language of tests to assess advanced cognitive impairment is a not covered need for Basque-speaking people. The present work shows the validation of the Basque version of the Severe Mini Mental State Examination (SMMSE).Material and methods
A total of 109 people with advanced dementia (MEC < 15) took part in the validation study, and were classified as GDS 5-7 on the Geriatric Depression Scale (GDS). All participants were Spanish-Basque bilingual.Results
It was shown that SMMSE-eus has a high internal consistency (alpha = 0.92), a good test-retest reliability (r = 0.88; P < .01), and a high inter-rater reliability (CCI = 0.99; P < .00) for the overall score, as well as for each item.Conclusions
Both the high internal consistency and inter-rater reliability, and to a lesser extent, test-retest reliability, made the SMMSE-eus a valid test for the brief assessment of cognitive status in people with advanced dementia in Basque-speaking people. For this reason, the SMMSE-eus is a usable and reliable alternative for assessing Basque-speaking people in their mother-tongue, or preferred language. 相似文献8.
9.
Pilar Zueras Jeroen Spijker Amand Blanes 《Revista espa?ola de geriatría y gerontología》2018,53(2):66-72
Introduction
The increasing participation of women in the workforce may make it difficult to sustain the current model of elderly care. The aim of this article was to determine the changing sociodemographic profile of informal elderly caregivers with disabilities, the interaction between employment and care, and the view of the public on the responsibility of that care.Materials and methods
Cross-sectional analysis of secondary data from four national surveys were used: the disability surveys held in 1999 (N = 3,936) and 2008 (N = 5,257), the 2011-12 National Health Survey (N = 439), and the Family and Gender survey of 2012 (N = 1,359). They were analysed using contingency tables based on gender and age.Results
Half of the informal caregivers were women aged 45 to 64 years. Between 1999 and 2011-12 they became more concentrated in the 55-64 age-bracket, among whom participation in the workforce doubled from 20% to 40%. Increased care for men was associated with unemployment. Care work had a negative impact on working life, with greater impact among women and those who cared for elderly people with severe disabilities. Less likely to consider that elderly care provision should rest on family are 45-54 year-old economically active women (only 42%) or those who are more educated (40%), compared to 60% of economically inactive women and 55% of less educated women.Conclusions
Economically active and educated women are less inclined to family-based care, but assume it independently of their workforce participation, whereas males do so according to their availability. 相似文献10.
Claudio Farías-Valenzuela Cristian Pérez-Luco Rodrigo Ramírez-Campillo Cristian Álvarez Mauricio Castro-Sepúlveda 《Revista espa?ola de geriatría y gerontología》2018,53(3):141-144
Background
Handgrip strength (HS) and peak oxygen consumption (Vo2peak) are powerful predictors of cardiovascular risk, although it is unknown which of the two variables is the better predictor.Aim
The objective of the following study was to relate HS and Vo2peak to cardiovascular risk markers in older Chilean women.Methods
Physically active adult women (n = 51; age, 69 ± 4.7 years) participated in this study. The HS and Vo2peak were evaluated and related to the anthropometric variables of body mass, body mass index (BMI), waist circumference (WC), hip circumference (HC), waist ratio (WR), and waist height ratio (WHR), as well as with the cardiovascular variables systolic (SBP) and diastolic (DBP) and cardiac recovery in one minute (RHR1). A multilinear regression model was used for the analysis of the associated variables (P < .05).Results
The cardiovascular risk markers associated (P < .05) with the handgrip strength of the dominant limb (HSDL) were body mass, BMI, WR, and WHR. The handgrip strength of the non-dominant limb (HSNDL) was associated with body mass. Vo2peak was associated with body mass, BMI, HC and RHR1. The multilinear regression model showed a value of r = 0.43 in HSDL, r = 0.39 in HSNDL and r = 0.69 in peak Vo2.Conclusion
Although HS and Vo2peak were related to cardiovascular risk markers, Vo2peak offers greater associative power with these cardiovascular risk factors. 相似文献11.
Miguel Ángel De la Cámara Sara Higueras-Fresnillo David Martinez-Gomez Óscar L. Veiga 《Revista espa?ola de geriatría y gerontología》2018,53(6)
Introduction
Physical activity and physical inactivity patterns can affect health status. In the elderly people, their study is relevant given the importance that they have on the morbidity and mortality.Objective
To present preliminary data on activity and inactivity patterns of a sub-sample of older adults from the IMPACT65+ Study.Material and methods
The sample included the first 84 participants (57% women) over 65 years (age 70.7±4.7). Time spent in activity and inactivity patterns was obtained from an Intelligent Device for Energy Expenditure and Activity monitor over a continuous period of 24 hours. The patterns analysed were: standing, lying down, sitting or reclining, and the transition between them. The physical activity patterns analysed were; walking, step up or step down, running, and jumping.Results
Time spent in inactivity patterns like reclining, lying down, and sitting was 16.1±1.9 hours (67% day), while the amount of time spent in activity patterns was 2.4±1.9 hours (10% day). Differences were observed between men and women in the amount of hours sitting (9.7±3 men vs. 7.5±2.7 women) and standing (4.5±1.4 men vs. 5.6±2.7 women). These differences were greater in the older participants.Conclusions
Preliminary results show that older adults spend a great part of day in inactivity patterns like sitting, and that gender is the only factor analysed that affects the time spent in the activity patterns analysed. 相似文献12.
Rafael Bielza Galindo Jesús Llorente Gutiérrez José Luis Pérez González Asunción Mora Casado David Blanco Díaz Javier Escalera Alonso Adoración Morales Fernández Cristina Molano Ortiz Beredys Esmirla García López Nazaret del Amo del Arco Juan Pablo Barro Ordovas Estefanía Arias Muñana Marta Neira Álvarez David Sanz Rosa Jorge Fco. Gómez Cerezo 《Revista espa?ola de geriatría y gerontología》2018,53(1):38-44
Introduction
There are no previous studies evaluating the effect of intravenous iron therapy on functional and cognitive status of patients with hip fracture (HF).Material and methods
A single-centre randomised, placebo-controlled, double-blind and parallel treatment, clinical trial has been designed to assess the efficacy of intravenous iron therapy during the peri-operative period in elderly patients suffering from a HF. Blinding will be ensured by the packaging of the drug infusion system. On days 1, 3, and 5 from admission, the intervention group will receive 200 mg Venofer® (iron sucrose) diluted in 100 ml saline, and the control group 100 ml saline, also on days 1, 3 and 5. Patients will received conventional treatment in ortho-geriatric unit of the Hospital Infanta Sofia. Functional variables (activities of daily living and walking), cognitive (cognitive status and delirium), surgical, demographic and clinical characteristics will be collected during admission in order to assess the impact of treatment. A safety analysis of the treatment will also performed. Patients will be followed-up at 3, 6, and 12 months.Results
The study will attempt to provide evidence on the impact of the intravenous iron administration on functional recovery. It will be determined whether iron therapy negatively affects the incidence of post-operative delirium. Finally, report will be presented on the safety data of intravenous iron in elderly HF patients, as well as the impact on allogenic blood transfusion savings.Conclusions
The inclusion of elderly HF patients admitted to an ortho-geriatric unit, in a clinical trial, will help to improve the knowledge of the treatment impact on a usual scenario, and provide useful data for use in other units. 相似文献13.
Oriol Turró Garriga Sílvia Farrés Costa Albert Pérez Terré Pau Batlle Amat 《Revista espa?ola de geriatría y gerontología》2018,53(4):196-201
Introduction
The care of dependent persons is arduous, and requires time, energy, and physical effort on the part of caregivers. Personal characteristics, such as the sense of coherence (SOC), can influence the perceived burden and care giving.Objective
To determine the impact of SOC on the perceived burden and to determine if these characteristics are associated with adherence to a psycho-educational program for informal caregivers.Material and method
Prospective observational study of caregivers of dependent persons participating in the ‘School of Caregivers’, a psycho-educational program for family and paid caregivers. An analysis was made of the SOC-13 items and the results of the Zarit Burden Interview. The relationship between the SOC and the adherence to the program (≥ 50% sessions) was also analysed.Results
The study included 96 participants, with 71.9% family carers. The higher burden was associated with a lower SOC meaningfulness factor (β = –0.388; P = .002), and to be a relative vs. paid carer (β = –0.300; P = .010). Just over half (52.1%) of carers completed 50% or more sessions, and in the case of the relatives, this adherence increased by higher SOC (OR: 1.1, P = .034), and lower burden (OR: 0.95, P = .032). The lack of adherence of paid caregivers was not associated with any of the analysed variables.Conclusions
The sense of coherence and mainly the meaning, is a characteristic to take into account for the adaptation of interventions in caregivers and provide them with greater equity working more on the people who need it the most (lower SOC and greater burden). 相似文献14.
Eliana Patricia Dueñas Liliana Patricia Ramírez Elizabeth Ponce Carmen Lucía Curcio 《Revista espa?ola de geriatría y gerontología》2019,54(2):68-74
Introduction
The fear of falling has a high prevalence in the community, and intervention programs for this condition are scarce, making it is necessary to strengthen this type of therapy in order to prevent adverse consequences in the elderly population.Objective
To establish the effectiveness of three intervention programs in reducing the fear of falling and increasing functionality in elderly people in the city of Manizales.Participants and methods
A randomised trial was conducted on ambulatory elderly patients with fear of falling and functional limitation of the city of Manizales. A total of 125 individuals were randomised to one of three interventions: Tai Chi (TCh), cognitive behavioural therapy (CBT), and postural control (CP) exercises. The primary outcomes were: fear of falling (evaluated by the Falls Efficacy Scale [FES-I]), and functionality using the Short Physical Performance Battery (SPPB). The data was collected before initiating the interventions and after the 8 weeks intervention.Results
An intention-to-treat analysis was conducted on 119 elderly patients. The three interventions reduced the fear of falling and increased physical performance, with no significant differences observed between them (P = .13). As regards gait speed, differences were only found between the pre- and post-intervention with CP (P < .001).Conclusions
The results suggest that the TCh, CBT and CP interventions helped the elderly to reduce their fear of falling. Only CP demonstrated an improvement in the speed of walking at the end of the eight weeks of intervention (identifier NCT03211429). 相似文献15.
I. Jardak F. Hamza Y. Hentati W. Amouri F. Kallel M. Maaloul S. Charfeddine K. Chtourou Z. Mnif F. Guermazi 《Médecine Nucléaire》2018,42(2):78-87
Aim of the study
Show the added value of SPECT-CT of the trunk in the diagnosis of bone metastases, compare its results to those of whole body scintigraphy (WBS) and specify the diagnostic impact while taking into account the cost of additional irradiation attributable to the scanner.Patients and methods
Prospective study including 150 patients presenting neoplasic pathology between June 2013 and December 2014. All patients have had WBS followed by a SPECT-CT of the axial skeleton.Results
A total of 1375 lesions were noted, of which 15.7 % were not seen in the WBS. The rate of indeterminate lesions increased from 18.7 % in the WBS to 1.9 % in the SPECT-CT. The concordance and discordance rates between WBS and SPECT-CT in the characterization of lesions according to their nature were 63.9 % and 1.5 %, respectively. The rib cage and the thoracic spine were the first localizations of the suspicious lesions of malignancy in SPECT-CT. Patient analysis showed a reduction in the number of scintigraphies classified as indeterminate to the WBS of 69 %. It also made it possible to better specify the metastatic extension without modification of the status in 32 patients and to change the status of the patient in 6 cases. SPECT-CT did not provide additional information to the WBS in 47 patients. The effective dose of 4 mSv was due to emission imaging while the scanner delivered an average effective dose estimated at 10.4 mSv.Conclusion
The SPECT-CT of the trunk has an indisputable contribution since it improves the quality of the report, reduces the number of undecided exams and increases the confidence level in favor of a non-significant irradiation. 相似文献16.
Juan Ignacio González-Montalvo Coro Mauleón Ladrero Rocío Menéndez-Colino Sara Hernández-Gutiérrez Raquel Ramírez-Martín Macarena Díaz-de Bustamante Francisco Sanz Segovia Francisco Robles Agudo Teresa Alarcón Alarcón 《Revista espa?ola de geriatría y gerontología》2019,54(2):94-98
Introduction
Hospital occupancy rate by older patients is high, and it will be even higher in the future. Their hospital stay is usually longer, making it important for hospitals to develop structures with the best efficiency possible.Method
Hospital discharges of patients older than 75 years with the 15 most frequent Diagnosis-Related Groups (DRG) in Geriatrics were recorded during a 5-year period in a 1,200-bed hospital. Length of stay was compared between the two acute geriatric units (AGU), one in the general hospital (GH) and another in an affiliate hospital (AH), as well as with the rest of departments.Results
A total of 14,948 discharged patients were included. Length of stay was 2.9 (25%) days shorter in AGU units than in the rest of departments. Differences were 22% (9.2 vs 11.7 days) in 2011, 16% (9.3 vs 11.1 days) in 2012, 21% (9.3 vs 11.1 days) in 2013, 34% (7.4 vs 11.1 days) in 2014, and 25% (8.3 vs 11 days) in 2015 in the GH. Differences were 18% (10.4 vs 12.7 days) in 2011, 19% (9.5 vs 11.7 days) in 2012, 25% (8.8 vs 11.7 days) in 2013, 24% (8.8 vs 11.6 days) in 2014, and 32% (9 vs 13.1 days) in 2015 at the AH, all of them with a P < .05.Conclusions
AGU are 25% more efficient than the rest of hospital departments in managing hospital admissions of patients older than 75 years. 相似文献17.
Juan José Calvo Aguirrey Josu Alustiza Navarro Joana Uranga Zaldúa Cristina Sarasqueta Eizaguirre Olga Bueno Yáñez 《Revista espa?ola de geriatría y gerontología》2018,53(5):255-261
Introduction
Physical and psychological functional conditions are key factors in the elderly population. Many evaluation tools are available, but they cannot be applied to the whole geriatric population. The use Alusti Test is presented. This test consists of 2 versions, which enable it to encompass this wide and complex population spectrum.Materials and methods
A prospective study with the institutionalised, hospitalised, and community population, was conducted between September and December 2016. A comparative analysis was conducted using the Barthel Index (BI), Gait Speed Test (GST), Timed «Up & Go» Test (TUG), Short Physical Performance Battery (SPPB), and Tinetti Test.Results
A total of 363 subjects were enrolled (mean age: 83.25 years), with varying levels of functional and cognitive conditions. The test was simple and quick to apply (3–6 min), 100% applicable and usable with broad floor and ceiling effects (0-100 points) with an intraclass correlation coefficient (ICC) that shows a high inter-observer reliability (ICC = 0.99), and a good correlation in its full version with BI (ICC = 0.86) (95% CI: 0.82-0.88), and the Tinetti test (ICC = 0.76; 95% CI: 0.71-0.81), as well as in the abbreviated version BI (ICC = 0.71; 95% CI: 0.65-0.75) and Tinetti Test (ICC = 0.90; 95% CI: 0.88-0.92). This allows the variation of the functional condition to be measured, which in our sample showed an increase of 10.9%, after a period of hospital admission.Conclusions
It is considered that Alusti test meets the requirements for physical performance assessment in the whole the geriatric population. The highest level of accuracy is given by the Tinetti test, which has greater applicability. 相似文献18.
19.
José Mauricio Ocampo-Chaparro José Ignacio Mosquera-Jiménez Annabelle S. Davis Carlos A. Reyes-Ortiz 《Revista espa?ola de geriatría y gerontología》2018,53(1):19-22
Introduction
The aim of this study was to analyse the effect of cognitive impairment on functional decline in hospitalised patients aged ≥ 60 years.Methods
Measurements at admission included demographic data, Charlson's comorbidity index, and cognitive impairment (according to education level).Data were also collected on hospital length of stay, depression, and delirium developed during hospitalisation. The outcome, Barthel Index (BI), was measured at admission, discharge, and 1-month post-discharge. Patients with BI ≤ 75 at admission (n = 54) or with a missing BI value were excluded (n = 1). Multivariate logistic regression analyses were conducted to explore predictive factors with functional decline (BI ≤ 75) from admission to discharge, and 1-month later.Results
Of the 133 patients included, 24.8% and 19.6% had a BI ≤ 75 at discharge and at 1-month, respectively. Compared with men, women had more than double risk for functional decline at discharge and 1-month (P < .05). Compared with those without delirium and without cognitive impairment, those with delirium and cognitive impairment had an increased risk for functional decline (BI ≤ 75) at discharge (OR 5.15, 95% CI; 1.94-13.67), and at 1-month (OR 6.26, 95% CI; 2.30-17.03). Similarly, those with comorbidity (≥ 2) had increased functional decline at discharge (OR 2.36, 95% CI; 1.14-4.87), and at 1-month after discharge (OR 2.71, 95% CI; 1.25-5.89).Conclusion
Delirium during hospitalisation, together with cognitive impairment on admission, was a strong predictor of functional decline. 相似文献20.
Federico Gordo Cristina Castro Inés Torrejón Sonia Bartolomé Francisco Coca Ana Abella 《Revista espa?ola de geriatría y gerontología》2018,53(4):213-216