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1.
J. M. Bateman 《Bulletin of mathematical biology》1986,48(5-6):525-543
A theoretical study is made of three organ flow models with heterogeneity of capillary transit times. A new parametrization
of Rose and Goresky's Model III facilitates in many cases a reduction to Goresky's Model II, accomplished by a special time
shift. The shift parameter
defined here is critical in this analysis of Model III. A new expression of the series for outflow concentration in Model
III is given and proves useful in examining the model as an operator and in relating it to Models I and II. A result on parameter
optimization is given: if
then Model III cannot fit better than Model II. This is applied to some data from Rose and Goresky [Circulation Res.
39, 541–544 (1976)] and raises a new question about their model. A heart model of Levin and Bassingthwaighte based on regional
flow measurement is shown to be a discretized generalization of Model II.
This work supported in part by PHS Grant Nos. HL-19153 (SCOR for Pulmonary Vascular Disease) and HL-19370 at Vanderbilt University. 相似文献
2.
Didier G. Arqués Jean-Paul Fallot Christian J. Michel 《Bulletin of mathematical biology》1998,60(1):163-194
The self-complementary subset
∪{AAA,TTT} with
= {AAC, AAT, ACC, ATC, ATT, CAG, CTC, CTG, GAA, GAC, GAG, GAT, GCC, GGC, GGT, GTA, GTC, GTT, TAC, TTC} of 22 trinucleotides
has a preferential occurrence in the frame 0 (reading frame established by the ATG start trinucleotide) of protein (coding)
genes of both prokaryotes and eukaryotes. The subsets
∪{CCC} and
∪{GGG} of 21 trinucleotides have a preferential occurrence in the shifted frames 1 and 2 respectively (frame 0 shifted by
one and two nucleotides respectively in the 5′-3′ direction).
and
are complementary to each other. The subset
contains the subset
which has the rarity property (6 × 10−8) to be a complementary maximal circular code with two permutated maximal circular codes
and
in the frames 1 and 2 respectively.
is called a C3 code.
A quantitative study of these three subsets
in the three frames 0, 1, 2 of protein genes, and the 5′ and 3′ regions of eukaryotes, shows that their occurrence frequencies
are constant functions of the trinucleotide positions in the sequences. The frequencies of
in the frame 0 of protein genes are 49, 28.5 and 22.5% respectively. In contrast, the frequencies of
in the 5′ and 3′ regions of eukaryotes, are independent of the frame. Indeed, the frequency of
in the three frames of 5′ (respectively 3′) regions is equal to 35.5% (respectively 38%) and is greater than the frequencies
and
, both equal to 32.25% (respectively 31%) in the three frames.
Several frequency asymmetries unexpectedly observed (e.g. the frequency difference between
and
in the frame 0), are related to a new property of the subset
involving substitutions. An evolutionary analytical model at three parameters (p, q, t) based on an independent mixing of the 22 codons (trinucleotides in frame 0) of
with equiprobability (1/22) followed by t ≈ 4 substitutions per codon according to the proportions p ≈ 0.1; q ≈ 0.1 and r = 1 − p − q ≈ 0.8 in the three codon sites respectively, retrieves the frequencies of
observed in the three frames of protein genes and explains these asymmetries. Furthermore, the same model (0.1, 0.1, t) after t ≈ 22 substitutions per codon, retrieves the statistical properties observed in the three frames of the 5′ and 3′ regions.
The complex behaviour of these analytical curves is totally unexpected and a priori difficult to imagine. 相似文献
3.
P. Padmini S. K. Rakshit K. Krishnaiah A. Baradarajan 《Bioprocess and biosystems engineering》1994,11(1):39-42
The authors have developed a continuous recycle reactor which efficiently performs emulsion type enzymatic reactions. The reactor column is filled with immobilised lipase and the reactions are effected by pumping the pre-prepared oil-water emulsion through the bottom of the reactor. A part of the product was recycled back and this type of recycling greatly improves the productivity of fatty acid compared to continuous once-through reactor without recycling. The recycle reactor could be continuously run for 35 days without decrease in conversions. The performance of the reactor was interpreted by a model and the theoretical conversion was compared with the experimental data.List of Symbols
F
AO
mol/min
feed rate
-
K
M g/l
Michaelis constant
-
R
recycle ratio
-
r
5
mol/(ml · min)
reaction rate
-
S
0 g/l
initial substrate concentration
-
V
max
mol/(ml · min)
maximum reaction velocity
-
V
R l
void volume of the reactor
-
x
s
fractional conversion
- Standard deviation
相似文献
4.
In the past years, several frequency-domain causality measures based on vector autoregressive time series modeling have been suggested to assess directional connectivity in neural systems. The most followed approaches are based on representing the considered set of multiple time series as a realization of two or three vector-valued processes, yielding the so-called Geweke linear feedback measures, or as a realization of multiple scalar-valued processes, yielding popular measures like the directed coherence (DC) and the partial DC (PDC). In the present study, these two approaches are unified and generalized by proposing novel frequency-domain causality measures which extend the existing measures to the analysis of multiple blocks of time series. Specifically, the block DC (bDC) and block PDC (bPDC) extend DC and PDC to vector-valued processes, while their logarithmic counterparts, denoted as multivariate total feedback $f^\mathrm{m}$ and direct feedback $g^\mathrm{m}$ , represent into a full multivariate framework the Geweke’s measures. Theoretical analysis of the proposed measures shows that they: (i) possess desirable properties of causality measures; (ii) are able to reflect either direct causality (bPDC, $g^\mathrm{m})$ or total (direct + indirect) causality (bDC, $f^\mathrm{m})$ between time series blocks; (iii) reduce to the DC and PDC measures for scalar-valued processes, and to the Geweke’s measures for pairs of processes; (iv) are able to capture internal dependencies between the scalar constituents of the analyzed vector processes. Numerical analysis showed that the proposed measures can be efficiently estimated from short time series, allow to represent in an objective, compact way the information derived from the causal analysis of several pairs of time series, and may detect frequency domain causality more accurately than existing measures. The proposed measures find their natural application in the evaluation of directional interactions in neurophysiological settings where several brain activity signals are simultaneously recorded from multiple regions of interest. 相似文献
5.
M. -T. Linossier D. Dormois R. Fouquet A. Geyssant C. Denis 《European journal of applied physiology and occupational physiology》1996,74(5):420-427
A group of 15 untrained male subjects pedalled on a friction-loaded cycle ergometer as fast as possible for 5–7 s to reach
the maximal velocity (V{immax}) against different braking forces (F
B). Power was averaged during a complete crank rotation by adding the power dissipated againstF
B to the power necessary to accelerate the flywheel. For each sprint, determinations were made of peak power output (
) power output attained atV
max (
) calculated as the product ofV
max andF
B and the work performed to reachV
max expressed in mean power output (
). The relationships between these parameters andF
B were examined. A biopsy taken from the vastus lateralis muscle and tomodensitometric radiographs of both thighs were taken
at rest to identify muscle metabolic and morphometric properties. The
value was similar for allF
B. Therefore, the average of values was defined as corrected maximal power (
). This value was 11 higher than the maximal power output uncorrected for the acceleration. Whereas the
determination did not require high loads, the highest
value (
) was produced when loading was heavy, as evidenced by the
-F
B parabolic relationship. For each subject, the braking force (
) giving
was defined as optimal. The
, equal to 0.844 (SD 0.108) N · kg−1 bodymass, was related to thigh muscle area (r = 0.78,P < 0.05). The maximal velocity (
) reached against this force seemed to be related more to intrinsic fibre properties (% fast twitch b fibre area and adenylate
kinase activity). Thus, from the
determination, it is suggested that it should be possible to predict the conditions for optimal exercise on a cycle ergometer. 相似文献
6.
D. L. Evans R. J. Rose 《Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology》1988,157(6):791-799
Summary Six Standardbred horses were used to evaluate the time course of pulmonary gas exchange, ventilation, heart rate (HR) and acid base balance during different intensities of constant-load treadmill exercise. Horses were exercised at approximately 50%, 75% and 100% maximum oxygen uptake (
max) for 5 min and measurements taken every 30 s throughout exercise. At all work rates, the minute ventilation, respiratory frequency and tidal volume reached steady state values by 60 s of exercise. At 100%
max, the oxygen consumption (
) increased to mean values of approximately 130 ml/kg·min, which represents a 40-fold increase above resting
. At the low and moderate work rates,
showed no significant change from 30 s to 300 s of exercise. At the high work rate, the mean
at 30 s was 80% of the value at 300 s. The HR showed no significant change over time at the moderate work rate but differing responses at the low and high work rates. At the low work rate, the mean HR decreased from 188 beats/min at 30 s to 172 beats/min at 300 s exercise, whereas at the high work rate the mean HR increased from 204 beats/min at 30 s to 221 beats/min at 300 s exercise. No changes in acid base status occurred during exercise at the low work rate. At the moderate work rate, a mild metabolic acidosis occurred which was nonprogressive with time, whereas the high work rate resulted in a progressive metabolic acidosis with a base deficit of 16 mmol/l by 300 s exercise. It is concluded that the kinetics of gas exchange during exercise are more rapid in the horse than in man, despite the relatively greater change in
in the horse when going from rest to high intensity exercise.Symbols and abbreviations E
minute ventilation
-
V
T
tidal volume
-
oxygen uptake
-
carbon dioxide output
-
oxygen pulse
-
ventilatory equivalent for oxygen
-
ventilatory equivalent for carbon dioxide
- R
respiratory exchange ratio
- HR
heart rate
- SBC
standard bicarbonate
- STPD
standard temperature and pressure dry
- BTPS
body temperature and pressure saturated
-
arterial oxygen content
-
arteriovenous oxygen content difference
- Rf
respiratory frequency 相似文献
7.
Syun’iti Iwao 《Population Ecology》1976,18(1):243-260
Summary and Conclusion The measurement of spatial association between two species is considered on the basis of interspecies mean crowding. Two indices
of overlapping, γ andC
μ, are derived as geometric and weighted arithmetic means of the same component ratios related to inter- and intraspecies mean
crowdings. Both indices behave in a similar way, ranging from 1 when the distributions of two species are completely overlapped
to 0 when they are completely exclusive with each other. The former is essentially identical with indices proposed byKuno (1968) andPianka (1973), and the latter is a modified form ofMorisita’s (1959)C
δ index. Indices to measure the degree of spatial correlation between species, ω andR
μ, are then derived for both kinds of overlapping indices, which vary from 1 in complete overlapping, through 0 in independent
occurrence, to −1 in complete exclusion.
Various kinds of interspecies association are analyzed using these indices and an extended form of the
regression graph which provides a convenient way of indicating the spatial interrelation between two species as well as distribution
patterns of respective species.
The method presented in this paper may also be applicable to compare temporal distribution patterns between species, similarity
between communities, etc. For such a wider application which includes continuous as well as discrete distributions, the interpretation
of intra- and interspecies mean crowdings is not necessarily appropriate, and hence the concept of mean concentration with
the symbols
and
for intraspecies relation and
and
for interspecies relation is suggested.
This study was supported by Science Research Fund (No. 148041) from the Ministry of Education. 相似文献
8.
Jean-Philippe Bellenger Françoise Arnaud-Neu Zouhair Asfari Satish C. B. Myneni Edward I. Stiefel Anne M. L. Kraepiel 《Journal of biological inorganic chemistry》2007,12(3):367-376
Azotochelin is a biscatecholate siderophore produced by the nitrogen-fixing soil bacterium Azotobacter vinelandii. The complexation properties of azotochelin with a series of oxoanions [Mo(VI), W(VI) and V(V)] and divalent cations [Cu(II),
Zn(II), Co(II) and Mn(II)] were investigated by potentiometry, UV–vis and X-ray spectroscopy. Azotochelin forms a strong 1:1
complex with molybdate (log K = 7.6 ± 0.4) and with tungstate and vanadate; the stability of the complexes increases in the order Mo < V < W (log K
appMo = 7.3 ± 0.4; log K
appV = 8.8 ± 0.4 and log K
appW = 9.0 ± 0.4 at pH 6.6). The Mo atom in the 1:1 Mo–azotochelin complex is bound to two oxo groups in a cis position and to the two catecholate groups of azotochelin, resulting in a slightly distorted octahedral configuration. Below
pH 5, azotochelin appears to form polynuclear complexes with Mo in addition to the 1:1 complex. Azotochelin also forms strong
complexes with divalent metals. Of the metals studied, Cu(II) binds most strongly to azotochelin , followed by Zn(II) , Mn(II) and Co(II) . Since very few organic ligands are known to bind strongly to oxoanions (and particularly molybdate) at circumneutral pH,
the unusual properties of azotochelin may be used for the separation and concentration of oxoanions in the laboratory and
in the field. In addition, azotochelin may prove useful for the investigation of the biogeochemistry of Mo, W and V in aquatic
and terrestrial systems.
Electronic supplementary material Supplementary material is available in the online version of this article at and is accessible for authorized users. 相似文献
9.
To evaluate the order and the values of Markov properties of the time series of events, we have proposed a statistical measure dependency:D
m
= (H
0
–H
m
)/H
0
, whereH
0 andH
m are Shannon's entropy and them-th order conditional entropy, respectively. It is indicated that
is a better point estimator ofD
m, giving a total value of them-th order Markov process. Here
and
are the estimate ofD
m and the arithmetic mean of
when them-th order shuffling is made many times for a given observed series, respectively. The value
represents Markov value of the orderm. Under the assumption that the series has continuous variables and the normal distribution, simplified dependency is defined by, where |S
m
| is the determinant of serial correlation coefficients. It is shown that is practically useful for the estimation of the order and the values of Markov processes with small sample size. It is also indicated that analysis is basically equivalent to the least mean-square analysis of autoregressive models. 相似文献
10.