医院国家自然科学基金项目申报精细化管理探讨

国家自然科学基金中标情况是评价科研实力的重要指标,强调精、准、细、严的精细化管理是提高基金申报中标的重要管理措施。通过分析2012—2016年某医院国家自然科学基金的申报和中标情况,结合医院基金申报的精细化管理实践,提出可将精细化管理用于基金项目申报,提高基金申报质量和中标率。     

对动物源性医疗器械免疫原性评价的思考

近年来,动物源性医疗器械产品的咨询和申报数量明显上升。本文对动物源性医疗器械申报现状进行了介绍,并结合技术审评的情况,对该类产品免疫原性的评价进行思考,以期对该类产品的申报注册有所帮助。     

学校召开新增硕士学位授予单位立项建设申报工作会议

正2018年7月17日下午,党委书记赵正洲在学术交流中心西湖厅主持召开武生院新增硕士学位授予单位立项建设申报工作会议,各学院院长及部分教授、博士参加了会议。会上,党委书记赵正洲进一步传达并解析了《省政府学位委员会关于开展新增博士硕士学位授予单位建设申报工作的通知》(鄂学位函[2018]5号)精神以及相关申报指标内涵,具体部署了我校新增硕士学位授予单位立项建设申报工作。     

五台山文化景观遗产突出普遍价值及其保护探讨

世界文化景观遗产的申报,是近年来国内越来越关注的话题,作为中国第一个成功以文化景观列入世界遗产名录的案例,五台山的申报过程为中国的文化景观遗产申报与研究提供了很多线索,尤其在突出普遍价值的认识及其保护管理方面,更是积累了一定的经验,同时也引发了新的思考。经过申报前后对遗产价值标准的对比研究及对保护管理的重新思考,认识到文化景观必须将自然、文化作为一个整体加以认知和保护,尤其要研究人与自然之间的作用机制,重视其中活态遗产的保护和展示。     

提高注册人员素质维护制药企业利益

概述药品注册申报人员的职业要求及其在制药企业中的作用,分析目前药品注册工作存在的问题,并强调加强药品注册申报人员能力建设,使其在制药企业发挥出重要的作用。     

关于申报第十四届“李汝祺动物遗传奖”的通知

中国遗传学会2012年申报第十四届"李汝祺动物遗传奖"工作已启动,申报时间从2012年9月25日至2013年5月31日。请有意申报"李汝祺动物遗传奖"的国内从事动物遗传学研究的青年学者(1967年以后出生),按申请书的要求填报,所提供的文章应该是国内工作在国内外期刊正式发表的。"李汝祺动物遗传奖"条例和申请书电子版请登陆学     

对胶原基创面修复材料安全性评价的思考

近年来,胶原基创面修复类医疗器械产品的咨询和申报数量明显上升。本文对胶原基创面修复材料现状进行了介绍,并结合技术审评的情况,对其安全性的评价进行思考,以期对该类产品的申报注册有所帮助。     

中国实验动物学会获中国科协学科发展研究项目资助

根据中国科协“关于申报2012年度中国科协学术交流项目的通知（科协学函[2012]78号）”通知精神,中国实验动物学会积极参与了项目申报工作。日前,该项目已获批准。近两年来,实验动物学科为适应飞速发展的生命科学,国内外的实验动物科学同样取得了很大进展。     

在美国进行植物药开发的路径、要求及策略探讨

近年来,越来越多药企开始在美国进行植物药的临床试验申请和新药申报,美国 FDA 日益重视植物药的开发,于 2016 年 12 月 发布并实施了修订版的《行业指南:植物药》,为植物药后期开发提供更多专业建议。结合 FDA 已经批准的 2 个植物药案例,详细介绍 植物药 CMC(化学、生产、控制)、临床前研究和过往人用历史方面的基本要求,浅谈 FDA 的申报要求、审评思想和申报策略,以期 为中国中药企业的国际化开发和注册提供参考。     

甲型H1N1流感疫苗生产用工作毒种的质量控制

根据中国药典2005年版三部和WHO"人用大流行流感疫苗制备的指导原则"相关要求,以及各企业的申报规程,对全国10家甲型H1N1流感疫苗生产企业工作毒种A/Californ ia/07/2009 NYMC X-179A进行毒种检定,结果均符合中国药典2005年版三部和各企业申报规程的要求。     

A Unique Protease Cleavage Site Predicted in the Spike Protein of the Novel Pneumonia Coronavirus (2019-nCoV) Potentially Related to Viral Transmissibility

正Dear Editor,In December 2019, a novel human coronavirus caused an epidemic of severe pneumonia(Coronavirus Disease 2019,COVID-19) in Wuhan, Hubei, China(Wu et al. 2020; Zhu et al. 2020). So far, this virus has spread to all areas of China and even to other countries. The epidemic has caused 67,102 confirmed infections with 1526 fatal cases     

Curcuminoids as inhibitors of thioredoxin reductase: A receptor based pharmacophore study with distance mapping of the active site

Curcumin is the yellow pigment of turmeric that interacts irreversibly forming an adduct with thioredoxin reductase (TrxR), an enzyme responsible for redox control of cell and defence against oxidative stress. Docking at both the active sites of TrxR was performed to compare the potency of three naturally occurring curcuminoids, namely curcumin, demethoxy curcumin and bis-demethoxy curcumin. Results show that active sites of TrxR occur at the junction of E and F chains. Volume and area of both cavities is predicted. It has been concluded by distance mapping of the most active conformations that Se atom of catalytic residue SeCYS498, is at a distance of 3.56 from C13 of demethoxy curcumin at the E chain active site, whereas C13 carbon atom forms adduct with Se atom of SeCys 498. We report that at least one methoxy group in curcuminoids is necessary for interation with catalytic residues of thioredoxin. Pharmacophore of both active sites of the TrxR receptor for curcumin and demethoxy curcumin molecules has been drawn and proposed for design and synthesis of most probable potent antiproliferative synthetic drugs.     

Comparative morphology of the carpel in the Liliaceae: Hewardieae, Petrosavieae, and Tricyrteae

The young pistils in the melanthioid tribes, Hewardieae, Petrosavieae and Tricyrteae, are uniformly tricarpellate and syncarpous. They lack raphide idioblasts. All are multiovulate, with bitegmic ovules. The Petrosavieae are marked by the presence of septal glands and incomplete syncarpy. Tepals and stamens adhere to the ovary in the Hewardieae and the Petrosavieae but not in the Tricyrteae. Two vascular bundles occur in the stamens of the Hewartlieae and Tricyrtis latifolia. Ventral bundles in the upper part of the ovary of the Hewardieae are continuous with compound septal bundles and placental bundles in the lower part. Putative ventral bundles occur in the alternate position in the Tricyrteae and putative placental bundles in the opposite. position in the Petrosavieae. The dichtomously branched stigma in each carpel of the Tricyrteae is supplied by a bifurcated dorsal bundle.     

Enterovirus 71 3C proteolytically processes the histone H3 N-terminal tail during infection

Highlights
1. The N-terminal tail of histone H3 is specifically cleaved during EV71 infection.
2. Viral protease 3C is identified as a protease responsible for proteolytically processing the N-terminal H3 tail.
3. Our finding reveals a new epigenetic regulatory mechanism for Enterovirus 71 in virus-host interactions.     

Detection of EBV and HHV6 in the Brain Tissue of Patients with Rasmussen’s Encephalitis

Rasmussen’s encephalitis (RE) is a rare pediatric neurological disorder, and the exact etiology is not clear. Viral infection may be involved in the pathogenesis of RE, but conflicting results have reported. In this study, we evaluated the expression of both Epstein-Barr virus (EBV) and human herpes virus (HHV) 6 antigens in brain sections from 30 patients with RE and 16 control individuals by immunohistochemistry. In the RE group, EBV and HHV6 antigens were detected in 56.7% (17/30) and 50% (15/30) of individuals, respectively. In contrast, no detectable EBV and HHV6 antigen expression was found in brain tissues of the control group. The co-expression of EBV and HHV6 was detected in 20.0% (6/30) of individuals. In particular, a 4-year-old boy had a typical clinical course, including a medical history of viral encephalitis, intractable epilepsy, and hemispheric atrophy. The co-expression of EBV and HHV6 was detected in neurons and astrocytes in the brain tissue, accompanied by a high frequency of CD8⁺ T cells. Our results suggest that EBV and HHV6 infection and the activation of CD8⁺ T cells are involved in the pathogenesis of RE.     

Perinatal Vertical Transmission of Chikungunya Virus in Ruili,a Town on the Border between China and Myanmar

正Dear Editor,Chikungunya virus (CHIKV), an arbovirus in the family of Togaviridae, genus Alphavirus, is transmitted by the A.aegyptii or A. albopictus mosquito, and causes disease in humans characterized by fever, rash, and arthralgia (Silva and Dermody 2017; Suhrbier 2019). It was first reported in 1953 in Tanzania, and caused only a few outbreaks and sporadic cases in Africa and Asia in last century. However, in the epidemic in 2004, CHIKV acquired mutations that conferred enhanced transmission by the A. albopictus mosquito(Schuffenecker et al. 2006). Since then, it has successively caused outbreaks in Africa, the Indian Ocean, South East Asia, the South America, and Europe (Zeller et al. 2016).     

Development of a Novel Reverse Transcription Loop-Mediated Isothermal Amplification Method for Rapid Detection of SARS-CoV-2

In conclusion, the novel visual RT-LAMP assay is a simple, rapid, and sensitive approach for detection of SARS-CoV-2, and it is ready for application in primary care and community hospitals or health care centers, and even patients' own houses in response to the current SARS-CoV-2 epidemic because the assay does not require sophisticated equipment and skilled personnel. Furthermore, it is also ready to be used in fields for screening samples from wild animals and environments to facilitate the identification of potential intermediate hosts that mediate the cross-species transmission of SARS-CoV-2 from bats to humans.