蜂胶中黄酮类化合物药理作用研究进展

黄酮类化合物是广泛存在于自然植物中的次级代谢产物,具有多种保健功能。蜂胶(propolis)是蜜蜂收集不同树植物的树脂、分泌物与蜜蜂唾液混合而成的具有芳香气味的物质,含有丰富的黄酮类化合物。综述了对蜂胶中黄酮类化合物的抗肿瘤、损伤保护、降血糖、抗氧化等多种药理作用的研究进展,以期为蜂胶黄酮类化合物相关药用研究提供参考。     

柚皮素:新一代免疫调节剂

大量研究表明,植物来源的黄酮类化合物具有广泛的生理活性和药理作用,日常摄取适量的黄酮类化合物能够显著降低许多疾病的发生.柚皮素作为一种自然界分布广泛的黄酮类化合物富含于水果、蔬菜、坚果、咖啡、茶和红酒等日常饮食中,与其他黄酮类化合物相比柚皮素易于胃肠道吸收、生物利用度高且安全剂量大.自2004年起我们对柚皮素调节免疫的分子机制进行了深入系统的研究.本文将重点介绍柚皮素作为一种新型免疫调节剂的研究进展.     

综述: 柚皮素：新一代免疫调节剂

大量研究表明,植物来源的黄酮类化合物具有广泛的生理活性和药理作用,日常摄取适量的黄酮类化合物能够显著降低许多疾病的发生.柚皮素作为一种自然界分布广泛的黄酮类化合物富含于水果、蔬菜、坚果、咖啡、茶和红酒等日常饮食中,与其他黄酮类化合物相比柚皮素易于胃肠道吸收、生物利用度高且安全剂量大.自2004年起我们对柚皮素调节免疫的分子机制进行了深入系统的研究.本文将重点介绍柚皮素作为一种新型免疫调节剂的研究进展.     

补骨脂中异戊烯基黄酮类化合物及其药理作用研究进展

综述补骨脂(Psoralea corylifolia)中的异戊烯基黄酮类化合物及其药理作用的研究进展.     

山绿茶化学成分及药理作用研究

综述山绿茶的化学成分、药理作用和临床应用等研究进展。山绿茶对心血管系统、呼吸系统、免疫系统等具有显著的药理作用;山绿茶富含黄酮类、三萜及其皂苷类、咖啡酰奎宁酸类、半萜苷(酯)类等化学成分,这些化合物可能与上述的药理作用密切相关。为进一步利用山绿茶药材资源,应对其具体药理作用的物质基础作进一步研究。     

玫瑰花渣中黄酮类化合物的检测与提取纯化

玫瑰精油的提取会产生大量玫瑰花渣,对环境产生很大污染。同时,玫瑰花渣中含有大量黄酮类化合物,具有显著的药理作用。出于对玫瑰花渣资源开发利用之目的,本研究从工业化角度研究了玫瑰花渣中黄酮类化合物的检测方法及提取和纯化工艺。结果表明,与氯化铝显色法相比,硝酸铝显色法稳定可靠,更适于玫瑰花渣的黄酮含量测定。70%乙醇有利于从玫瑰花渣中提取黄酮类化合物,提取物中黄酮含量为14.60%,提取得率达2.63%。经AB-8大孔树脂纯化后,黄酮含量为53.23%,回收率达35.84%。本研究结果可为玫瑰花渣资源开发提供参考。     

萝藦科马利筋族植物化学成分研究进展(Ⅱ)

综述了到目前为止,从马利筋族植物中发现的黄酮、强心甙、生物碱、萜类、苯衍生物类等成分的种类及其分布,并介绍了一些化合物的药理作用以及黄酮类和C21甾体化合物在鹅绒藤属化学分类中的作用.     

萝Mo科马利筋族植物化学成分研究进展（Ⅱ）

综述了到目前为止,从马利筋族植物中发现的黄酮、强心甙、生物碱、萜类、苯衍生物类等成分的种类及其分布,并介绍了一些化合物的药理作用以及黄酮类和Ｃ２１甾体化合物 鹅绒藤属化学分类中的作用。     

仙人掌属植物的研究进展

对仙人掌属植物的化学成分和药理学研究进展进行了综述。其主要成分为黄酮类化合物、生物碱、多糖等;主要药理作用有抗炎、降血糖、抗病毒、抗菌等。     

我国药用菊花的化学及药理学研究新进展

对我国药用菊花植物的化学成分和药理学研究进展进行了综述.其主要成分为挥发油、黄酮类化合物等.主要药理作用有抗炎、镇痛、抗病毒、抗菌、抗衰老、抗肿瘤、抗病毒等.     

金丝桃属植物研究进展

金丝桃属植物中许多种是传统草药．二总酮类、类黄酮类及间苯三酚类等次生代谢产物具有许多药理作用。因此近年来对该属植物的分泌结构、具药理作川的化学成分、快速繁殖以及分子水平的研究越来越多。本文就以上各方面的研究进展作一综述。     

Metabolic engineering of flavonoids in plants and microorganisms

Over 9,000 flavonoid compounds have been found in various plants, comprising one of the largest families of natural products. Flavonoids are an essential factor in plant interactions with the environment, often serving as the first line of defense against UV irradiation and pathogen attacks. Flavonoids are also major nutritional compounds in foods and beverages, with demonstrated health benefits. Some flavonoids are potent antioxidants, and specific flavonoid compounds are beneficial in many physiological and pharmacological processes. Therefore, engineering of flavonoid biosynthesis in plants or in microorganisms has significant scientific and economical importance. Construction of biosynthetic pathways in heterologous systems offers promising results for large-scale flavonoid production by fermentation or bioconversion. Genomics and metabolomics now offer unprecedented tools for detailed understanding of the engineered transgenic organism and for developing novel technologies to further increase flavonoid production yields. We summarize some of the recent metabolic engineering strategies in plants and microorganisms, with a focus on applications of metabolic flux analysis. We are confident that these engineering approaches will lead to successful industrial flavonoid production in the near future.     

Flavonoids and related compounds as inhibitors of arachidonic acid peroxidation

Until now only few data have been reported on biochemically explicable pharmacological effects of flavonoid structures. When tested against arachidonic acid metabolism many flavonoids were found to be effective against the lipoxygenase and cyclo-oxygenase pathways. Some flavonoids were predominant inhibitors of either cyclo-oxygenase or lipoxygenase, others were equally effective against both enzymes. Therefore, these compounds proved to be useful tools to elucidate fatty acid peroxidation problems.     

老鸦烟筒花的化学成分及药理作用研究进展

通过查阅近年来国内外的文献,对紫葳科植物老鸦烟筒花(Millingtonia hortensis L.)的化学成分及药理活性研究现状进行了整理和总结。老鸦烟筒花的主要化学成分和有效成分均为黄酮类化合物,另外还包括生物碱类、环己乙醇类、苯丙素苷类和三萜类等多种类型的化合物,药理活性显著,具有止咳、抗菌、消炎、抗癌、抗突变、驱虫、治疗糖尿病等多种作用。     

Tissue-Specific,Development-Dependent Phenolic Compounds Accumulation Profile and Gene Expression Pattern in Tea Plant [Camellia sinensis]

Phenolic compounds in tea plant [Camellia sinensis (L.)] play a crucial role in dominating tea flavor and possess a number of key pharmacological benefits on human health. The present research aimed to study the profile of tissue-specific, development-dependent accumulation pattern of phenolic compounds in tea plant. A total of 50 phenolic compounds were identified qualitatively using liquid chromatography in tandem mass spectrometry technology. Of which 29 phenolic compounds were quantified based on their fragmentation behaviors. Most of the phenolic compounds were higher in the younger leaves than that in the stem and root, whereas the total amount of proanthocyanidins were unexpectedly higher in the root. The expression patterns of 63 structural and regulator genes involved in the shikimic acid, phenylpropanoid, and flavonoid pathways were analyzed by quantitative real-time polymerase chain reaction and cluster analysis. Based on the similarity of their expression patterns, the genes were classified into two main groups: C1 and C2; and the genes in group C1 had high relative expression level in the root or low in the bud and leaves. The expression patterns of genes in C2-2-1 and C2-2-2-1 groups were probably responsible for the development-dependent accumulation of phenolic compounds in the leaves. Enzymatic analysis suggested that the accumulation of catechins was influenced simultaneously by catabolism and anabolism. Further research is recommended to know the expression patterns of various genes and the reason for the variation in contents of different compounds in different growth stages and also in different organs.     

Erratum to: “Spiroflavonoid Compounds: Structure and Distribution in Nature Review”

This review summarizes the results of research aimed at isolation and structural characterization of flavonoid compounds belonging to a new class, namely, spirobiflavonoids, from different plant sources.     

Spiroflavonoid compounds: Structure and distribution in nature review

This review summarizes the results of research aimed at isolation and structural characterization of flavonoid compounds belonging to a new class, namely, spirobiflavonoids, from different plant sources.     

天然间苯三酚的化学结构和药理活性研究进展

天然的间苯三酚类化合物来源广泛、结构新颖,具有多种药理活性,是目前天然药物化学的研究热点之一。本文对近十年发现的天然间苯三酚类化合物的化学结构和药理活性的研究进展做了调研和综述,以期对该类化合物进一步的研究提供参考。     

Quercetin as an inhibitor of snake venom secretory phospholipase A2

As polyphenolic compounds isolated from plants extracts, flavonoids have been applied to various pharmaceutical uses in recent decades due to their anti-inflammatory, cancer preventive, and cardiovascular protective activities. In this study, we evaluated the effects of the flavonoid quercetin on Crotalus durissus terrificus secretory phospholipase A2 (sPLA2), an important protein involved in the release of arachidonic acid from phospholipid membranes. The protein was chemically modified by treatment with quercetin, which resulted in modifications in the secondary structure as evidenced through circular dichroism. In addition, quercetin was able to inhibit the enzymatic activity and some pharmacological activities of sPLA2, including its antibacterial activity, its ability to induce platelet aggregation, and its myotoxicity by approximately 40%, but was not able to reduce the inflammatory and neurotoxic activities of sPLA2. These results suggest the existence of two pharmacological sites in the protein, one that is correlated with the enzymatic site and another that is distinct from it. We also performed molecular docking to better understand the possible interactions between quercetin and sPLA2. Our docking data showed the existence of hydrogen-bonded, polar interactions and hydrophobic interactions, suggesting that other flavonoids with similar structures could bind to sPLA2. Further research is warranted to investigate the potential use of flavonoids as sPLA2 inhibitors.