Familial long-read sequencing increases yield of de novo mutations

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High-coverage whole-genome sequencing of the expanded 1000 Genomes Project cohort including 602 trios

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Functional genetics of human gut commensal Bacteroides thetaiotaomicron reveals metabolic requirements for growth across environments

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Single-cell multiome sequencing clarifies enteric glial diversity and identifies an intraganglionic population poised for neurogenesis

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Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course

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Simple oligonucleotide-based multiplexing of single-cell chromatin accessibility

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The Early Evolution of Oral Poliovirus Vaccine Is Shaped by Strong Positive Selection and Tight Transmission Bottlenecks

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Hierarchy in Hfq Chaperon Occupancy of Small RNA Targets Plays a Major Role in Their Regulation

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Multiplatform Molecular Profiling Reveals Epigenomic Intratumor Heterogeneity in Ependymoma

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Spatial mapping reveals human adipocyte subpopulations with distinct sensitivities to insulin

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Bi-allelic variants in DNHD1 cause flagellar axoneme defects and asthenoteratozoospermia in humans and mice

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A Two-Layered Targeting Mechanism Underlies Nuclear RNA Sorting by the Human Exosome

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High-resolution analyses of associations between medications,microbiome, and mortality in cancer patients

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Overlapping transcriptional programs promote survival and axonal regeneration of injured retinal ganglion cells

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Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma

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Co-transcriptional splicing regulates 3′ end cleavage during mammalian erythropoiesis

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A Single-Cell Transcriptomic Atlas of Human Skin Aging

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Midbrain organoids mimic early embryonic neurodevelopment and recapitulate LRRK2-p.Gly2019Ser-associated gene expression

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Decoding the temporal and regional specification of microglia in the developing human brain

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Brain Endothelial Cells Are Exquisite Sensors of Age-Related Circulatory Cues

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