Structure-guided optimization of light-activated chimeric G-protein-coupled receptors

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A Conserved PDZ-Binding Motif in aPKC Interacts with Par-3 and Mediates Cortical Polarity

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Computational Modeling of Protein Stability: Quantitative Analysis Reveals Solutions to Pervasive Problems

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Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal

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Co-crystallization with diabodies: A case study for the introduction of synthetic symmetry

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Optimization of Protein Thermostability and Exploitation of Recognition Behavior to Engineer Altered Protein-DNA Recognition

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Engineering a modular double-transmembrane synthetic receptor system for customizing cellular programs

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Upstream continuous processing: recent advances in production of biopharmaceuticals and challenges in manufacturing

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Structure and engineering of the minimal type VI CRISPR-Cas13bt3

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Dipeptidylpeptidase 4 promotes survival and stemness of acute myeloid leukemia stem cells

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AGC kinases and MAB4/MEL proteins maintain PIN polarity by limiting lateral diffusion in plant cells

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Phage-assisted evolution and protein engineering yield compact,efficient prime editors

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Proximity labeling reveals non-centrosomal microtubule-organizing center components required for microtubule growth and localization

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Enhanced safety and efficacy of protease-regulated CAR-T cell receptors

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Engineered miniature CRISPR-Cas system for mammalian genome regulation and editing

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CTP regulates membrane-binding activity of the nucleoid occlusion protein Noc

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Hsf1 promotes hematopoietic stem cell fitness and proteostasis in response to ex vivo culture stress and aging

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Genetic requirements for cell division in a genomically minimal cell

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Disease-linked mutations cause exposure of a protein quality control degron

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Hematopoietic stem cells preferentially traffic misfolded proteins to aggresomes and depend on aggrephagy to maintain protein homeostasis

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