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Inhibition of Th2 differentiation and GATA-3 expression by BCL-6 总被引:6,自引:0,他引:6
Kusam S Toney LM Sato H Dent AL 《Journal of immunology (Baltimore, Md. : 1950)》2003,170(5):2435-2441
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Repression of c-myc is necessary but not sufficient for terminal differentiation of B lymphocytes in vitro 总被引:9,自引:0,他引:9 下载免费PDF全文
The importance of c-myc as a target of the Blimp-1 repressor has been studied in BCL-1 cells, in which Blimp-1 is sufficient to trigger terminal B-cell differentiation. Our data show that Blimp-1-dependent repression of c-myc is required for BCL-1 differentiation, since constitutive expression of c-Myc blocked differentiation. Furthermore, ectopic expression of cyclin E mimicked the effects of c-Myc on both proliferation and differentiation, indicating that the ability of c-Myc to drive proliferation is responsible for blocking BCL-1 differentiation. However, inhibition of c-Myc by a dominant negative form was not sufficient to drive BCL-1 differentiation. Thus, during Blimp-1-dependent plasma cell differentiation, repression of c-myc is necessary but not sufficient, demonstrating the existence of additional Blimp-1 target genes. 相似文献
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The human transcriptional repressor protein NAB1: expression and biological activity 总被引:4,自引:0,他引:4
Thiel G Kaufmann K Magin A Lietz M Bach K Cramer M 《Biochimica et biophysica acta》2000,1493(3):289-301
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c-Jun/激活蛋白-1活性调节研究进展 总被引:3,自引:0,他引:3
转录因子激活蛋白-1(AP-1)对细胞增殖、细胞存活与细胞凋亡等重要生理过程具有调控作用,其核心组成成分是c-Jun.c-Jun活性从转录调控、翻译后调控(主要是磷酸化调节)和相互作用蛋白质调节等三个水平受到正负向调控.其分子内8个位点可被JNK1、GSK3、CKII、Abl等激酶磷酸化.通过N端的转录激活结构域和C端的碱性亮氨酸拉链区,c-Jun可与bZIP类转录因子、辅助激活因子和其他一些蛋白质直接相互作用而被调控.另外一些分子可通过CBP、JAB1等重要辅助激活因子的介导间接调控AP-1的活性,共同构成AP-1活性调节的复杂网络. 相似文献