共查询到10条相似文献,搜索用时 171 毫秒
1.
2.
3.
A short nucleotide sequence required for regulation of HIS4 by the general control system of yeast 总被引:48,自引:0,他引:48
We have made deletions of the HIS4 5' noncoding region in vitro and inserted these deletions into the yeast genome by transformation. Deletions that extend from -588 to -235 have no detectable effects on either promoter or regulatory functions. Deletions that extend to -138 affect promoter function, but are still regulated by the general control of amino acid biosynthesis. A deletion that extends to -136 cannot derepress HIS4 mRNA in response to the general control. This deletion removes all copies of the sequence 5'-TGACTC-3', which appears at positions -194, -182 and -138 in strains without the deletion. The importance of at least one copy of this repeat for regulation of HIS4 is shown by the reappearance of this sequence in revertants of the -136 deletion that have regained the regulatory response. The fact that deletion of this sequence leads to the inability to derepress suggests that HIS4 is under positive control. 相似文献
4.
5.
6.
7.
8.
The general control of amino acid biosynthetic genes in the yeast Saccharomyces cerevisiae 总被引:18,自引:0,他引:18
A G Hinnebusch 《CRC critical reviews in biochemistry》1986,21(3):277-317
9.
Multiple upstream AUG codons mediate translational control of GCN4 总被引:128,自引:0,他引:128
10.