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《Molecular & cellular proteomics : MCP》2019,18(6):1085-1095
Highlights
- •Rapamycin and zinc induce moderate but significant mitochondrial proteome changes.
- •The mitochondrial proteins processing system is robust under subtoxic conditions.
- •Rapamycin and zinc perturb the mitochondrial proteins processing system.
- •Rapamycin and zinc perturb the mitochondrial proteins homeostasis.
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Spatiotemporal Changes of the Phagosomal Proteome in Dendritic Cells in Response to LPS Stimulation*
《Molecular & cellular proteomics : MCP》2019,18(5):909-922
Highlights
- •Characterization of the phagosomal proteome comparing resting and LPS-treated BMDCs.
- •Label-free quantification determined 2843 phagosomal proteins.
- •Reduced recruitment of hydrolases and V-ATPase to phagosomes of LPS-treated cells.
- •Increased recruitment of antigen cross-presentation molecules to these phagosomes.
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《Molecular & cellular proteomics : MCP》2019,18(4):606-621
Highlights
- •In-depth proteome underpins the gland ontogeny and age-specific activity of the HGs.
- •The well-developed acini in the HGs of NBs promote the RJ secretary activities.
- •The enhanced protein and energy metabolism in the HGs boost the stronger RJ secretion of RJBs.
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《Molecular & cellular proteomics : MCP》2019,18(3):408-422
Highlights
- •Quantitative phosphoproteomics of cells treated with sphingolipid analogs or PP2A inhibitor identify novel protein targets of PP2A.
- •PP2A substrates include several nutrient transporter proteins, GTPase regulators and proteins associated with actin cytoskeletal remodeling.
- •Differential regulation of Akt and Gsk3b account for the difference in vacuolating phenotype observed between SH-BC-893 and C2-ceramide.
- •Dynamic phosphoproteomics enabled the correlation of cell signaling with phenotypes to rationalize their mode of action.
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《Molecular & cellular proteomics : MCP》2019,18(7):1285-1306
Highlights
- •Identification of previously undetected chloroplast envelope proteins.
- •Up to date manual annotation of genuine (or shared) envelope components.
- •New hypotheses for localizations, functions, interactions among cell compartments.
- •A new resource of significant value to the broader plant science community.
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《Molecular & cellular proteomics : MCP》2019,18(7):1345-1362
Highlights
- •Plant mitoribosomes contain several pentatricopeptide repeat proteins.
- •The small mitoribosomal subunit is of an exceptionally large size.
- •Protein units not directly related to translation may be attached to plant mitoribosomes to confer additional functions to these molecular machines.
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《Molecular & cellular proteomics : MCP》2019,18(3):504-519
Highlights
- •Dimethyl fumarate covalently modifies cysteine residues in neurons and astrocytes.
- •Cofilin-1, tubulin and collapsin response mediator protein 2 (CRMP2) are targets.
- •DMF-modified cofilin-1 reduces actin-severing ability, preserving filamentous actin.
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《Molecular & cellular proteomics : MCP》2020,19(11):1739-1748
Highlights
- •Label-free and isobaric labeling approaches for in-depth profiling of single cells.
- •Miniaturization and simplification of sample processing reduce surface losses.
- •Nanoflow separations enhance ionization efficiency and reduced chemical noise.
- •Ultrasensitive mass spectrometry and gas-phase separation add selectivity.
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《Molecular & cellular proteomics : MCP》2019,18(6):1157-1170
Highlights
- •Auxin responsive proteins in Arabidopsis roots were identified from 3,514 detected proteins.
- •All six auxin receptors are stable in response to hormone via novel MRM assays.
- •The >100 differentially expressed proteins exhibit dynamic and transient responses to auxin.
- •Phenotypic screening of the top responsive proteins uncovered several novel root mutants.
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《Molecular & cellular proteomics : MCP》2019,18(4):657-668
Highlights
- •Global proteomic remodeling alters antibiotic susceptibility in K. pneumoniae.
- •Drug specific transport, sugar utilization, central metabolism, capsule synthesis.
- •Common pathways of reactive oxygen scavenging, turnover of misfolded proteins.
- •Integrated adjustments and unique drug-specific features for drug combinations.