共查询到20条相似文献,搜索用时 31 毫秒
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The product of the c-ets-1 proto-oncogene and the related Ets2 protein act as transcriptional activators of the long terminal repeat of human T cell leukemia virus HTLV-1 总被引:34,自引:3,他引:31 下载免费PDF全文
R Bosselut J F Duvall A Ggonne M Bailly A Hmar J Brady J Ghysdael 《The EMBO journal》1990,9(10):3137-3144
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Characterization of the human interleukin-2 receptor beta-chain gene promoter: regulation of promoter activity by ets gene products. 总被引:2,自引:2,他引:0 下载免费PDF全文
J X Lin N K Bhat S John W S Queale W J Leonard 《Molecular and cellular biology》1993,13(10):6201-6210
The interleukin-2 receptor (IL-2R) beta chain (IL-2R beta) is an essential signaling component of high- and intermediate-affinity IL-2Rs. Our laboratory previously reported that a DNA fragment containing 857 bp of 5'-flanking sequence of the human IL-2R beta gene exhibited promoter activity. We have now further characterized the promoter and delineated cis-acting regulatory regions. The region downstream of -363 is critical for basal and phorbol myristate acetate-inducible IL-2R beta promoter activity and contains at least three enhancer-like regions. Among them, the -56 to -34 enhancer was the most potent and had high-level activity in two T-cell lines but not in nonlymphoid HeLaS3 and MG63 cells. This enhancer contains a GGAA Ets binding site which bound two Ets family proteins, Ets-1 and GA-binding protein in vitro. Mutation of the Ets motif strongly diminished both promoter and enhancer activities. We conclude that this Ets binding site plays a key role in regulating basal and phorbol myristate acetate-inducible IL-2R beta promoter activity and may also contribute to tissue-specific expression of the IL-2R beta gene. 相似文献
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G Bensi M Mora G Raugei D T Buonamassa M Rossini M Melli 《Cell growth & differentiation》1990,1(10):491-497
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