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1.
Autophagy and innate immunity: Insights from invertebrate model organisms   总被引:2,自引:0,他引:2  
Cheng-Ju Kuo 《Autophagy》2018,14(2):233-242
  相似文献   

2.
The effect of population density on the growth of an animal population   总被引:1,自引:1,他引:0  

Contribution from the Department of Fisheries, Kyoto University.

Contribution from the Entomological Laboratory, Kyoto University, No. 201.  相似文献   

3.
《Journal of bryology》2013,35(4):532-536
Abstract

The chromosome numbers of five species belonging to the Jubulae have been described, and are as follows:

Lejeuneaceae

Cololejeunea cf. dissita, n = 9.

Arehilejeunea autoiea Vanden Berghen, n=9.

Caudalejeunea hanningtonii (Mitt.) Schiffn., n =9.

Mastigolejeunea florea (Mitt.) Steph., n=9.

Frullaniaceae

Frullania spongiosa Steph., female, n = 9.

F. spongiosa Steph., male, n=8.

The author wishes to thank Dr E. W. Jones for assistance in identifications, especially with Cololejeunea cf. dissita.  相似文献   

4.
Abstract

Peroxisome proliferator-activated receptors (PPARs) are considered important targets for the treatment of Type 2 diabetes (T2DM). To accelerate the discovery of PPAR α/γ dual agonists, the comparative molecular field analysis (CoMFA) were performed for PPARα and PPARγ, respectively. Based on the molecular alignment, highly predictive CoMFA model for PPARα was obtained with a cross-validated q2 value of 0.741 and a conventional r2 of 0.975 in the non-cross-validated partial least-squares (PLS) analysis, while the CoMFA model for PPARγ with a better predictive ability was shown with q2 and r2 values of 0.557 and 0.996, respectively. Contour maps derived from the 3D-QSAR models provided information on main factors towards the activity. Then, we carried out structural optimization and designed several new compounds to improve the predicted biological activity. To investigate the binding modes of the predicted compounds in the active site of PPARα/γ, a molecular docking simulation was carried out. Molecular dynamic (MD) simulations indicated that the predicted ligands were stable in the active site of PPARα/γ. Therefore, combination of the CoMFA and structure-based drug design results could be used for further structural alteration and synthesis and development of novel and potent dual agonists. Abbreviations DM diabetes mellitus

T2DM type 2 diabetes

PPARs peroxisome proliferator-activated receptors

LBDD ligand based drug design

3D-QSAR three-dimensional quantitative structure activity relationship

CoMFA comparative molecular field analysis

PLS partial least square

LOO leave-one-out

q2 cross-validated correlation coefficient

ONC optimal number of principal components

r2 non-cross-validated correlation coefficient

SEE standard error of estimate

F the Fischer ratio

r2pred predictive correlation coefficient

DBD DNA binding domain

MD molecular dynamics

RMSD root-mean-square deviation

RMSF root mean square fluctuations

Communicated by Ramaswamy H. Sarma  相似文献   

5.
《Epigenetics》2013,8(4):212-215
Dosage compensation is an essential process that equalizes X-linked gene dosage

between the sexes. In the worm Caenorhabditis elegans, a complex of proteins called the dosage

compensation complex (DCC) binds both X chromosomes in hermaphrodites to downregulate

gene expression two-fold and hence to reduce X-linked gene expression levels equal to that in

males. Five subunits of the DCC form the condensin IDC complex, a homolog of the

evolutionarily conserved condensin complex required for chromosome segregation and

compaction during mitosis and meiosis. How related complexes can perform such diverse

functions remains a mystery. Nevertheless, it is believed that the mitotic and interphase functions

of condensin are mechanistically related, and understanding one process will reveal new insights

into the other. We discuss how during worm dosage compensation a condensin-mediated

function may guide the organization of the interphase chromatin fibers, leading to the formation

of a repressive nuclear compartment.  相似文献   

6.
Abbreviations HAS human serum albumin

BSA bovine serum albumin

β-LG beta-lactoglobulin

cis-Pt and trans-Pt Pt(NH3)2Cl2

FTIR Fourier transform infrared

Communicated by Ramaswamy H. Sarma  相似文献   

7.
Studies on the Biosynthesis of Streptomycin   总被引:2,自引:0,他引:2       下载免费PDF全文
Myo-inositol, especially in combination with arginine, enhances streptomycin production. Compounds which show structural relationship with myo-inositol are ineffective.

Myo-inositol decreases the incorporation of C14-glucose into streptomycin, particularly into streptidine. This effect suggests that myo-inositol is a precursor of the streptidine ring.

Methionine stimulates antibiotic production in a synthetic medium but proves to be unfavorable in a complex medium.

The γ- and δ-isomers of hexachlorocyclohexane inhibit streptomycin formation.

The formation of streptomycin by washed mycelium was studied. Essentially the same results were here obtained as with growing cultures.

  相似文献   

8.

Masking in motor systems was defined as the omission of one act in a sequence due to an earlier or later act in the sequence. A study of phoneme omission in natural speech showed that:

  1. 1.

    Masked phonemes were usually preceded or followed by an identical phoneme (referred to as the masking phoneme).

  2. 2.

    Backward masking, where the masked phoneme preceded the masking phoneme was as frequent as forward masking.

  3. 3.

    The phonemes immediately adjacent to the masked and masking phonemes were usually similar in distinctive features, but rarely identical.

  4. 4.

    The masking phoneme usually occurred in a stressed syllable and the masked phoneme in an unstressed one, suggesting that motor intensity may be a factor in masking.

  5. 5.

    The components for an adequate model of motor masking were shown to be similar to those in models of other types of errors in speech.

  相似文献   

9.

über einige besondere Formen der Leberzellen, ihre Beziehungen zu den Gallenkapillaren und ihre Funktionelle Bedeutung

allievo interno

Mit 12 Textabbildungen.  相似文献   

10.
Shear Pleasure     
Ceramic Design, John B. Kenny Chilton Books, Publisher List price: $9.95

Illustrating Children's Books, Henry C. Pit Watson-Guptill Publisher List price: $9.75

Watercolor Landscape, Rex Brandt Reinhold Publishers List price: $10.00

Wood Carving, Freda Skinner Sterling Publishing Co. List price: $3.95

ABC Book of Early Americana, Eric Sloane Doubleday &; Co., Publisher List price: $2.95

The Best of Origami, Samuel Randlett E. P. Dutton, Publisher List price: $5.95

Romanesque Sculpture, Buoch &; Lohse Macmillan Company, Publisher List price: $12.95

International Poster Annual, edited by Arthur Niggli Hastings House, Publisher List price: $12.95

1800 Woodcuts, Thomas Bewick and His School Dover Publications List price: $10.00

Illustrators'63, Edited by Harry Carter Hastings House, Publishers List price: $15.00

Mosaics: Principles and Practice, Joseph Young Reinhold Publisher List prim $6.50

Reinhold Craft and Hobby Book, Gunther Voss Reinhold, Publisher List price: $8.95

The New How to Draw, Pihnan Drawing Series Pitman Publishing Co. List price: $4.95

Hand Bookbinding, Aldren A. Watson Reinhold Publishers List price $6.00

English Furniture of 18th Cen. David Nickerson Putnam's Sons Publisher List price: $4.95

Bronzes, Jennifer Mantagu Putnam's Sons Publisher List price: $4.95

The Craft of Woodcuts, John R. Biggs Sterling Publishing Co. List price: $2.95

The Art of Ancient Egypt, Shirley Glubok Atheneum, Publisher List price: $3.95

The Art of Ancient Greece, Shirley Glubok Atheneum, Publisher List price: $3.95

Life for Dead Spaces, C. Goodman, W. Van Eckardt Harcourt, Brace (L World List price: $12.50  相似文献   

11.

The Mediterranean evergreen vegetation of Sicily, comprised in the belt of the Quercetea ilicis, occupies a large part of the island. Human intervention (cutting, fire, pasture) has brought about a degradation of the natural vegetation. This study is based on our phytosociological research of the Quercetea ilicis belt on Sicily.

With the ‘habitat comparison’ method, the dynamical relations between the different vegetation units have been defined.

We distinguish the following stages, with reference to their vegetation structure:

  • a herbaceous stage formed by steppic vegetation, preceded by various types of nitrophilous-ruderal vegetation on abandoned fields;

  • a garrigue stage dominated by half-shrubs;

  • a macquis stage with various distinct plant communities, four communities being important in regressive successions, and three in progressive ones;

  • a woodland and shrub-woodland stage with three different substages: pre-existent forests, present woodlands, and woodlands which tend towards the final, stable stage of vegetation (potential natural vegetation).

The dynamic relationships both in progressive and regressive successions have been synthesized in a scheme. In this scheme we have shown the main stages of the vegetation in their dynamics and we have constructed different series of vegetation types in two altitudinal belts, which are determined by varying environmental conditions of today.

The results also show that in some cases the progressive series follow different pathways than the regressive series, and the final stage of the progressive series is different from the original vegetation.

  相似文献   

12.
Abbreviations SAHA suberoylanilide hydroxamic acid

EhHDAC Histone Deacetylase from Entamoeba histolytica

Rg Radius of gyration

RMSD root-mean-square deviation

RMSF root-mean-square fluctuation

MDS molecular dynamics simulation

VMD Visual Molecular Dynamics

NAMD Nanoscale Molecular Dynamics

PBC periodic boundary conditions

PME Particle Mesh Ewald

3D three-dimensional

Cα alpha carbon

FDA Food and Drug Administration

ns nanoseconds

GPU CUDA Graphics Processing Unit Compute Unified Device Architecture

Communicated by Ramaswamy H. Sarma  相似文献   

13.
Abbreviations ADME absorption, distribution, metabolism, and excretion

MMGB/SA molecular mechanics generalized born surface area

IFD induced fit docking

RTK receptor tyrosine kinase

NSCLC non-small-cell lung cancer

ATP adenosine triphosphate

OPLS optimized potential for liquid stimulation

RMSD root mean square deviation

HTVS high-throughput virtual screening

SP standard precision

XP extra precision

OPLS-AA optimized potential for liquid stimulation-all atom

MD molecular simulation

MME molecular mechanics energies

SGB surface generalized born

POPC membrane 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine membrane

PDB Protein Data Bank

DDR1 discoidin domain receptor 1

DDR2 discoidin domain receptor 2

DDRs discoidin domain receptors

ECM extracellular matrix

TIP4P transferable intermolecular potential 4 point

NPT constant particle number, pressure and temperature

RMSF root mean square fluctuation

Communicated by Ramaswamy H. Sarma  相似文献   

14.
Abstract

CARYOEMBRYOLOGICAL STUDIES in ORNITHOGALUM OF SARDINIA.

I. - SPOROGENESIS AND DEVELOPMENT OF THE GAMETOPHYTES IN ÒRNITHOGALUM CAUDATUM AIT. — After a concise synthesis of the caryoembryological knowledges regarding the taxa of Ornithogalum present in Sardinia, the embryology and morphology of Ornithogalum caudatum Ait., have been investigated.

In a three-locular ovary the ovules are anatropous, epitropous with nucellus crassinucellate and only one archesporial cell evolves a mother cell.

The development of the female gametophyte tallies with the Polygonum (Normal) Type.

The homoetypical division presents an asynchronous proceeding in the cellules of the dyad with a considerable delay in the two-nucleate arrangement, especially in the chalazal cell.

Antipodal cells present a hypertrophic growing, but they present no tendency to polyantipody.

The endosperm is of the Helobiae Type.

The divisions of the pollen mother-cells are of the successive Type.

Longest axis of 1-sulcate pollen grains about 76 micron.

A true tapetal periplasmodium isn't formed in the anthers.

The chromosome number is 2n = 54.

Raphides accour in the cataphylls, in the parenchymatous tissues of the leaf and in several parts of the floral region.  相似文献   

15.
16.
Purpose

Many consumers are transitioning away from single-use plastic products and turning to reusable alternatives. Oftentimes, this change is being made with the assumption that these alternatives have fewer environmental impacts; however, reusable products are frequently made from more environmentally intensive materials and have use phase impacts. This study used LCA to examine the GWP, water consumption, and primary nonrenewable energy use associated with reusable alternatives for single-use plastic kitchenware products and determined environmental payback periods.

Methods

The environmental impacts for each reusable alternative are calculated on the functional units of 1 use, 1 year (5 uses/week), and 5 years (5 uses/week). Payback periods are calculated for each reusable alternative and defined as the number of times a consumer must reuse an alternative in order for the environmental impact per use to be equivalent to the environmental impact for the single-use product. The research explored the sensitivity of the results to different consumer washing and reuse behaviors, as well as local conditions such as overall transportation distances and the carbon intensity of different electricity grids. Product types studied included straws (4 reusable, 2 single-use), sandwich storage (2 reusable, 3 single-use), coffee cups (3 reusable, 2 single-use), and forks (1 single-use, 3 reusable).

Results and discussion

Environmental impacts associated with the reusable alternatives were highly dependent on the use phase due to dishwashing, making payback period sensitive to washing frequency and method, and for GWP, carbon intensity of the energy grid (used for water heating). For single-use products, the material/manufacturing phase was the largest contributor to overall impacts. It was found that nine of the twelve reusable alternatives were able to breakeven in all three environmental indicators. The coffee cup product type was the only product type to have one reusable alternative, the ceramic mug, and have the shortest payback period for all three impact categories. Both the bamboo straw and beeswax wrap were unable to breakeven in any scenario due to high use phase impacts from manual washing.

Conclusions

The research found that reusable alternatives can payback the environmental impacts of GWP, water consumption, and energy use associated with their more resource intensive materials, but it is dependent on number of uses, consumer behavior, and for GWP, carbon intensity of the energy grid. A key takeaway is that consumer behavior and use patterns influence the ultimate environmental impact of reusable kitchenware products.

Recommendations

Some recommendations for consumers looking to reduce the overall impact of kitchenware products include the following:

  1. 1)

    Not always assuming reusable is the best option.

  2. 2)

    Extending product lifetime.

  3. 3)

    Researching which reusable option has the lowest impact.

  4. 4)

    Following best practice washing behaviors.

  5. 5)

    Not washing products after every use.

  6. 6)

    Advocating for integration of renewables into the local energy grid.

  7. 7)

    Reducing consumption of these product types (reusable or single-use).

  相似文献   

17.
Entry to medical schools; Harry Grenville

Nuffleld Advanced Biology

Environmental politics and policy

Grants for school nature areas

Biology in TVEI/CPVE courses - new handbook

New AV catalogue  相似文献   

18.
The observation of a double kidney pelvis with duplication of the ureter, which was found discordant in identical twins is demonstrated.

Stipendiat der Alexander-von-Humboldt-Stiftung.

Mit Unterstützung durch die Deutsche Forschungsgemeinschaft.  相似文献   

19.
20.

Functionalized compounds, which are difficult to produce by classical chemical synthesis, are of special interest as biotechnologically available targets. They represent useful building blocks for subsequent organic syntheses, wherein they can undergo stereoselective or regioselective reactions. “White Biotechnology” (as defined by the European Chemical Industry [http://www.europabio.org/white_biotech.htm], as part of a sustainable “Green Chemistry,”) supports new applications of chemicals produced via biotechnology. Environmental aspects of this interdisciplinary combination include:

  • Use of renewable feedstock

  • Optimization of biotechnological processes by means of:

    • New “high performance” microorganisms

    • On-line measurement of substrates and products in bioreactors

    • Alternative product isolation, resulting in higher yields, and lower energy demand

In this overview we describe biotechnologically produced pyruvic, 2-oxopentaric and 2-oxohexaric acids as promising new building blocks for synthetic chemistry. In the first part, the microbial formation of 2-oxocarboxylic acids (2-OCAs) in general, and optimization of the fermentation steps required to form pyruvic acid, 2-oxoglutaric acid, and 2-oxo-d-gluconic acid are described, highlighting the fundamental advantages in comparison to chemical syntheses. In the second part, a set of chemical formula schemes demonstrate that 2-OCAs are applicable as building blocks in the chemical synthesis of, e.g., hydrophilic triazines, spiro-connected heterocycles, benzotriazines, and pyranoic amino acids. Finally, some perspectives are discussed.

  相似文献   

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