共查询到20条相似文献,搜索用时 15 毫秒
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Albrecht U Yang X Asselta R Keitel V Tenchini ML Ludwig S Heinrich PC Häussinger D Schaper F Bode JG 《Cellular signalling》2007,19(9):1866-1878
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Respiratory syncytial virus-inducible BCL-3 expression antagonizes the STAT/IRF and NF-kappaB signaling pathways by inducing histone deacetylase 1 recruitment to the interleukin-8 promoter 下载免费PDF全文
Jamaluddin M Choudhary S Wang S Casola A Huda R Garofalo RP Ray S Brasier AR 《Journal of virology》2005,79(24):15302-15313
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STAT5 induces macrophage differentiation of M1 leukemia cells through activation of IL-6 production mediated by NF-kappaB p65 总被引:6,自引:0,他引:6
Kawashima T Murata K Akira S Tonozuka Y Minoshima Y Feng S Kumagai H Tsuruga H Ikeda Y Asano S Nosaka T Kitamura T 《Journal of immunology (Baltimore, Md. : 1950)》2001,167(7):3652-3660
We recently demonstrated that STAT5 can induce a variety of biological functions in mouse IL-3-dependent Ba/F3 cells; STAT5-induced expression of pim-1, p21(WAF/Cip1), and suppressor of cytokine signaling-1/STAT-induced STAT inhibitor-1/Janus kinase binding protein is responsible for induction of proliferation, differentiation, and apoptosis, respectively. In the present study, using a constitutively active STAT5A (STAT5A1*6), we show that STAT5 induces macrophage differentiation of mouse leukemic M1 cells through a distinct mechanism, autocrine production of IL-6. The supernatant of STAT5A1*6-transduced cells contained sufficient concentrations of IL-6 to induce macrophage differentiation of parental M1 cells, and STAT3 was phosphorylated on their tyrosine residues in these cells. Treatment of the cells with anti-IL-6 blocking Abs profoundly inhibited the differentiation. We also found that the STAT5A1*6 transactivated the IL-6 promoter, which was mediated by the enhanced binding of NF-kappaB p65 (RelA) to the promoter region of IL-6. These findings indicate that STAT5A cooperates with Rel/NF-kappaB to induce production of IL-6, thereby inducing macrophage differentiation of M1 cells in an autocrine manner. In summary, we have shown a novel mechanism by which STAT5 induces its pleiotropic functions. Cytokines 相似文献
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Oda T Ueda A Shimizu N Handa H Kasahara T 《Journal of immunology (Baltimore, Md. : 1950)》2002,169(6):3329-3335
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