共查询到20条相似文献,搜索用时 15 毫秒
1.
《Molecular & cellular proteomics : MCP》2019,18(9):1745-1755
Highlights
- •We have developed a decellularization protocol for ECM protein enrichment.
- •We have characterized the proteome of adult zebrafish heart ECM.
- •We describe dynamic changes in heart ECM proteome during regeneration.
- •We describe changes in heart ECM stiffness during regeneration.
2.
《Molecular & cellular proteomics : MCP》2019,18(5):936-953
Highlights
- •In-depth proteome profiling of primary human myeloma cells
- •Characteristics of myeloma cells are related to hypoxic bone marrow conditions
- •Myeloma cells show specific immune evasion strategies
- •Metabolic adaptations involve tumor and stroma cells
3.
《Molecular & cellular proteomics : MCP》2018,17(12):2496-2507
Highlights
- •Quantitative (phospho)proteome analysis of antibiotic treatment in E. coli.
- •Largest bacterial phosphorylation catalogue.
- •Specific phosphorylation motifs changes during resistance development.
- •Phosphorylation mediated signaling could be a potential target for drug design.
4.
《Molecular & cellular proteomics : MCP》2019,18(9):1705-1720
Highlights
- •Quantitative changes in global proteome and ubiquitinome in Huntington's disease.
- •Differential ubiquitination of wild-type and mutant Htt in mice brain.
- •Enriched pathways include vesicle transport and mRNA processing.
- •Correlation between protein and diGly site fold changes.
5.
《Molecular & cellular proteomics : MCP》2018,17(11):2119-2131
Highlights
- •Temporal proteome profiling of lipotoxicity and glucolipotoxicity in β-cells
- •Palmitate induced cholesterol metabolism earlier than fatty acid metabolism
- •Setd8 promotes palmitate + glucose-stimulated INS-1 cell proliferation
- •PA induced apoptosis partially via upregulation of Rhob in INS-1 cells
6.
《Molecular & cellular proteomics : MCP》2019,18(10):1939-1949
Highlights
- •Proteome profiling of tissue interstitial fluids (TIFs) of oral cancer.
- •Pathway of aminoacyl tRNA biosynthesis enriched in proteome of TIFs.
- •Verification of nidogen-1 as a salivary biomarker of oral cancer.
- •High correlation between elevated tissue level of nidogen-1 and poor survival.
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8.
Spatiotemporal Changes of the Phagosomal Proteome in Dendritic Cells in Response to LPS Stimulation*
《Molecular & cellular proteomics : MCP》2019,18(5):909-922
Highlights
- •Characterization of the phagosomal proteome comparing resting and LPS-treated BMDCs.
- •Label-free quantification determined 2843 phagosomal proteins.
- •Reduced recruitment of hydrolases and V-ATPase to phagosomes of LPS-treated cells.
- •Increased recruitment of antigen cross-presentation molecules to these phagosomes.
9.
《Molecular & cellular proteomics : MCP》2019,18(6):1110-1122
Highlights
- •Comprehensive analysis of inter-individual variation of normal urinary proteome.
- •Significant gender differences were observed.
- •Proteins increased in female urine are enriched in immunological pathways.
- •Estimated reference intervals of proteins as the baseline for biomarker discovery.
10.
11.
《Molecular & cellular proteomics : MCP》2019,18(6):1085-1095
Highlights
- •Rapamycin and zinc induce moderate but significant mitochondrial proteome changes.
- •The mitochondrial proteins processing system is robust under subtoxic conditions.
- •Rapamycin and zinc perturb the mitochondrial proteins processing system.
- •Rapamycin and zinc perturb the mitochondrial proteins homeostasis.
12.
《Molecular & cellular proteomics : MCP》2019,18(9):1864-1879
Highlights
- •Feeding mice a western-style obesogenic diet resulted in dramatic changes in fecal microbial proteome.
- •Basal fecal microbial proteome, but not microbiome, composition was associated with extent of diet-induced obesity.
- •A major feature of fecal microbial proteome of high-responder mice was enriched motility-related proteins.
13.
《Molecular & cellular proteomics : MCP》2019,18(2):391-405
Highlights
- •PTMiner software for intelligent post-processing of open-search results.
- •Unrestrictive modification site localization based on a Bayesian model.
- •Extended transfer FDR estimation for accurate grouped FDR estimation.
- •Comprehensive PTM characterization in a draft map of human proteome.
14.
《Molecular & cellular proteomics : MCP》2018,17(11):2146-2163
Highlights
- •Construction of threespine stickleback gill assay library using DDA proteomics
- •Population-specific gill proteome signatures of four ecotypes identified by DIA
- •HSP47 and extracellular matrix proteins highly elevated in warm-adapted sticklebacks
- •Inflammasome and proteolytic proteins highly elevated in freshwater sticklebacks
15.
《Molecular & cellular proteomics : MCP》2019,18(6):1210-1226
Highlights
- •Quantitative global proteome, acetylome and succinylome of phytoplasma-infected Paulownia tomentosa seedlings.
- •Acetylation may be more important than succinylation in response to phytoplasma infection.
- •Acetylation modified the activities of POR and RuBisCO.
- •Possible model to elucidate the molecular mechanism responses to PaWB from proteome and PTMs.
16.
《Molecular & cellular proteomics : MCP》2019,18(6):1123-1137
Highlights
- •Changes to the proteome of skin fibroblasts subjected to reductive stress have been quantitated.
- •Only a small set of proteins is selectively diminished upon exposure to reductants.
- •Collagens (COL1A2 and COL6A2) emerge as sentinels of reductive stress.
- •Reductive stress triggers receptor-independent Akt phosphorylation at Ser473.
17.
《Molecular & cellular proteomics : MCP》2019,18(4):773-785
Highlights
- •The developed Ac-LysargiNase showed higher stability and activity than before.
- •The merged spectra of the mirror peptides achieved nearly complete ion coverage.
- •pNovoM obviously increased the efficiency and accuracy of peptide sequencing.
- •The mirror enzymatic strategy achieved precision de novo sequencing on proteome scales.
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19.
《Molecular & cellular proteomics : MCP》2019,18(7):1468-1478
Highlights
- •TMT labeling protocol with excellent intra- and interlaboratory reproducibility.
- •Complete in-solution labeling of peptides using 1/8 of recommended TMT quantities.
- •Demonstration of utility for deep-scale (phospho)proteome analysis.
20.
《Molecular & cellular proteomics : MCP》2019,18(6):1036-1053
Highlights
- •Establishment of a flow system allowing multi-omics analysis of S. aureus biofilms.
- •Biofilm proteome profiling (intracellular and ECM) plus metabolic footprint analysis.
- •Virulence factors and ribosomal proteins stabilize the ECM as moonlighting proteins.
- •They act as electrostatic bridges between anionic cell surfaces, eDNA and metabolites.