共查询到20条相似文献,搜索用时 15 毫秒
1.
Joanne Yap Lois A Salamonsen Tom Jobling Peter K Nicholls Evdokia Dimitriadis 《Reproductive biology and endocrinology : RB&E》2010,8(1):63
Background
Interleukin (IL) 11 is produced by human endometrium and endometrial cancer tissue. It has roles in endometrial epithelial cell adhesion and trophoblast cell invasion, two important processes in cancer progression. This study aimed to determine the levels of IL11 in uterine lavage fluid in women with endometrial cancer and postmenopausal women. It further aimed to determine the levels of IL11 protein and its signaling molecules in human endometrial cancer of varying grades, and endometrium from postmenopausal women and IL11 signalling mechanisms in endometrial cancer cell lines. 相似文献2.
3.
Background
The endometrium prepares for implantation under the control of steroid hormones. It has been suggested that there are complicated interactions between the epithelium and stroma in the endometrium during menstrual cycle. In this study, we demonstrate a difference in gene expression between the epithelial and stromal areas of the secretory human endometrium using microdissection and macroarray technique. 相似文献4.
Ariane Germeyer Michael von Wolff Julia Jauckus Thomas Strowitzki Tanuj Sharma Anna T Grazul-Bilska 《Reproductive biology and endocrinology : RB&E》2010,8(1):67
Background
Reproductive failure, determined as recurrent spontaneous abortions (RSA) or recurrent implantation failure (RIF) in women is not well understood. Several factors, including embryo quality, and cellular and molecular changes in endometrium may contribute to the insufficient feto-maternal interaction resulting in reproductive failure. Prior clinical studies suggest an inadequate endometrial growth and development of the endometrium, leading to a lesser endometrial thickness. 相似文献5.
Michal Amir Shabtai Romano Shlomit Goldman Eliezer Shalev 《Reproductive biology and endocrinology : RB&E》2009,7(1):152-8
Background
To study the expression of Plexin-B1, Glycodelin, and MMP7 during the menstrual cycle in the endometrium and in the fallopian tube. 相似文献6.
Eva-Katrin Bentz Marina Kenning Christian Schneeberger Andrea Kolbus Johannes C Huber Lukas A Hefler Clemens B Tempfer 《Reproductive biology and endocrinology : RB&E》2010,8(1):38
Background
The stem cell marker Octamer-4 (OCT-4) is expressed in human endometrium. Menstrual cycle-dependency of OCT-4 expression has not been investigated to date. 相似文献7.
Gabriela F Meresman Carla Olivares Susana Vighi Margarita Alfie Marcela Irigoyen Juan J Etchepareborda 《Reproductive biology and endocrinology : RB&E》2010,8(1):126
Background
Various endometrial abnormalities have been associated with luteal phase deficiency: a significant dyssynchrony in the maturation of the glandular epithelium and the stroma and a prevalence of out-of-phase endometrial biopsy specimens. Out-of phase endometrium is a controversial disorder related to failed implantation, infertility and early pregnancy loss. Given that the regulation of the apoptotic process in endometrium of luteal phase deficiency is still unknown, the aim of this study was to evaluate cell proliferation, apoptosis and the levels of the main effector caspase, caspase-3 in the luteal in-phase and out-of-phase endometrium. 相似文献8.
Background
Selective estrogen receptor modulators (SERMs) have been developed in order to create means to control estrogenic effects on different tissues. A major drawback in treatment of estrogen receptor (ER) positive breast cancer with the antagonist tamoxifen (TAM) is its agonistic effect in the endometrium. Raloxifene (RAL) is the next generation of SERMs where the agonistic effect on the endometrium has been reduced. 相似文献9.
Ioannis Mylonas Ansgar Brüning Naim Shabani Susanne Kunze Markus S Kupka 《Reproductive biology and endocrinology : RB&E》2010,8(1):143
Background
Inhibins are important regulators of the female reproductive system. Recently, two new inhibin subunits betaC and betaE have been described, although it is unclear if they are synthesized in normal human endometrium. 相似文献10.
Malgorzata Szczepańska Przemyslaw Wirstlein Jana Skrzypczak Pawe? P Jagodziński 《Reproductive biology and endocrinology : RB&E》2012,10(1):1
Background
A decrease in HOXA11 expression in eutopic mid-secretory endometrium has been found in women with endometriosis-associated infertility. 相似文献11.
Background
The human endometrium is an important site for contact between the host and pathogens ascending the reproductive tract, and thus plays an important role in female reproductive tract immunity. Previous work in our laboratory has suggested that Toll-like receptors (TLRs) are involved in endometrial epithelial recognition of pathogens and that ligation of endometrial TLRs results in the production of cytokines and chemokines important for both immune and reproductive functions of the endometrium. We have also demonstrated cyclic regulation of TLR3 mRNA and protein expression in human endometrium, suggesting that steroid hormones might play a role in the expression and function of TLR3. In this study, the effects of 17beta-estradiol (E2) and progesterone (P) on TLR3 expression and function in endometrial cell lines were investigated. 相似文献12.
Pawel Basta Marcin Majka Wojciech Jozwicki Ewelina Lukaszewska Anna Knafel Marek Grabiec Elzbieta Stasienko Lukasz Wicherek 《Reproductive biology and endocrinology : RB&E》2010,8(1):116
Background
The presence of regulatory T (Treg) cells in human endometrium is crucial for maintaining immunological homeostasis within the uterus. For this study we decided to evaluate the subpopulations of Treg cells in conditions where a disturbance in the immunological equilibrium in ectopic endometrium and decidua has been observed, such as in cases of ovarian endometriosis (involving local immune cell suppression) and ectopic pregnancy (involving an increase in local immune system activity). We then compared these findings to what we observed in the normal eutopic endometrium of women during the secretory phase of the menstrual cycle (with immune cells under individual control). 相似文献13.
Steven D Fleming Asgerally T Fazleabas Stephen C Bell 《Reproductive biology and endocrinology : RB&E》2008,6(1):6
Background
The purpose of this study was to examine the effect of insulin on expression and synthesis of IGFBP-1 and IGFBP-2 in the baboon endometrium in vitro. 相似文献14.
Background
Endometriosis is a condition that affects women of reproductive age, where the glandular and/or stromal tissues from the eutopic endometrium implant in ectopic locations. It is well established that the survival of ectopic implants is due to lower levels of apoptosis, but no consensus exists as to which pathway/s this is mediated by. The ubiquitin protein shares a similar sequence homology to an anti-apoptotic protein called BAG-1 and is expressed in the normal endometrium. Currently, no studies have been conducted to determine ubiquitin expression and its possible anti-apoptotic effects in endometriosis. 相似文献15.
Svenja Allhorn Carsten Böing Andrea A Koch Rainer Kimmig Isabella Gashaw 《Reproductive biology and endocrinology : RB&E》2008,6(1):40
Background
Toll-like receptors (TLRs) play an essential role in the innate immune system by initiating and directing immune response to pathogens. TLRs are expressed in the human endometrium and their regulation might be crucial for the pathogenesis of endometrial diseases. 相似文献16.
Robert Kuo-Kuang Lee Chi-Chen Fan Yuh-Ming Hwu Chung-Hao Lu Ming-Huei Lin Ying-Jie Chen Sheng-Hsiang Li 《Reproductive biology and endocrinology : RB&E》2011,9(1):38
Background
SERPINE2, also known as protease nexin-1, belongs to the serine protease inhibitor (SERPIN) superfamily. It is one of the potent SERPINs that modulates the activity of plasminogen activators (PAs). PAs and their SERPIN inhibitors, such as SERPINB2 and SERPINE1, were expressed in the human endometrium and were implicated in implantation. However, expression data about SERPINE2 in the human endometrium is still unknown. Thus, we conducted an investigation to reveal the spatiotemporal and cellular expression of SERPINE2 in the human uterus during the menstrual cycle. 相似文献17.
Evdokia Dimitriadis Andrew M Sharkey Yee Lee Tan Lois A Salamonsen J Robert A Sherwin 《Reproductive biology and endocrinology : RB&E》2007,5(1):44-8
Background
Uterine receptivity and embryo implantation are critical in the establishment of pregnancy. The diagnosis of endometrial fertility requires more precise measurements of endometrial receptivity. Interleukin (IL-11) and leukemia inhibitory factor (LIF) are essential for murine implantation and signal via intracellular phosphorylation (p) of STAT3 in the endometrium. Both cytokines are present in the endometrium of women duiring the receptive window. Endometrial IL-11, IL-11 receptor alpha (IL-11Ralpha), LIF and pSTAT3 in women with primary unexplained infertility was compared to normal fertile women during the implantation window. 相似文献18.
Marissa A Bowden Ying Li Yi-Xun Liu Jock K Findlay Lois A Salamonsen Guiying Nie 《Reproductive biology and endocrinology : RB&E》2008,6(1):22
Background
HTRA3 is a recently identified member of the mammalian serine protease family HTRA (high temperature requirement factor A). In both the rodent and the human HTRA3 is transcribed into two mRNA species (long and short) through alternative splicing. We have previously shown that HTRA3 is expressed in the mature rat ovary and may be involved in folliculogenesis and luteinisation. HTRA3 is also upregulated during mouse and human placental development. The current study investigated whether HTRA3 is also localised in the primate ovary (rhesus monkey n = 7). In addition, we examined the non-pregnant rhesus monkey endometrium (n = 4) and maternal-fetal interface during early pregnancy (n = 5) to further investigate expression of HTRA3 in primate endometrium and placentation. 相似文献19.
Darren Davies Kieran G Meade Shan Herath P David Eckersall Deyarina Gonzalez John O White R Steven Conlan Cliona O'Farrelly I Martin Sheldon 《Reproductive biology and endocrinology : RB&E》2008,6(1):53
Background
The endometrium is commonly infected with bacteria leading to severe disease of the uterus in cattle and humans. The endometrial epithelium is the first line of defence for this mucosal surface against bacteria and Toll-like receptors (TLRs) are a critical component of the innate immune system for detection of pathogen associated molecular patterns (PAMPs). Antimicrobial peptides, acute phase proteins and Mucin-1 (MUC-1) also provide non-specific defences against microbes on mucosal surfaces. The present study examined the expression of innate immune defences in the bovine endometrium and tested the hypothesis that endometrial epithelial cells express functional receptors of the TLR family and the non-specific effector molecules for defence against bacteria. 相似文献20.