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1.
目的:探讨糖化血红蛋白(HbAlc)与糖尿病诊断、疗效评价及并发症的关系。方法:选择2型糖尿病患者250例和健康体检者150例,分别测定空腹血糖(FPG)、2h血糖(2hPG)及糖化血红蛋白(HbA1c),统计学分析HbA1c与FPG、2hPG的相关性;分析HbA1c与糖尿病并发症发生的关系。结果:糖尿病组FPG、2hPG及HbA1c水平均显著高于对照组(P<0.01);糖尿病伴有并发症患者的HbAlc明显高于无并发症者(P<0.05),HbA1c水平与糖尿病并发症的发生率存在高度相关性(P<0.01)。结论:检测外周血中HbA1c水平对2型糖尿病诊断、疗效评价具有重要临床价值,控制糖化血红蛋白对预防糖尿病并发症的发生具有重要意义。  相似文献   

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目的:研究血清Fractalkine(FKN)、爱帕琳肽(Apelin)水平与糖尿病视网膜病变(DR)患者血糖、血脂以及病程的关系。方法:选取我院于2015年1月至2016年12月收治的160例糖尿病患者为研究对象,行眼底荧光造影、裂隙灯显微镜检查,按照检查结果将其区分为非增生型DR组(稳定组,43例)、背景期DR组(背景组,62例)和增殖期DR组(增殖组,55例),另外于同期选取我院40例健康体检者为健康对照组(健康组),测量4组血清FKN、Apelin、空腹血糖(FPG)、餐后2h血糖(2hPG)、糖化血红蛋白(HbA1c)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)和总胆固醇(TC)水平,使用Pearson相关性分析分析血清FKN、Apelin与FPG、2hPG、HbA1c、HDL-C、LDL-C、TG、TC、糖尿病病程的相关性。结果:血清FKN、Apelin水平比较:增殖组背景组稳定组健康组,各组间比较差异具有统计学意义(P0.05);血清FPG、2hPG、HbA1c、LDL-C、TG、TC水平比较:增殖组背景组稳定组健康组,各组间比较差异具有统计学意义(P0.05);血清HDL-C水平比较:健康组稳定组背景组增殖组,各组间比较差异具有统计学意义(P0.05);采用Pearson相关性分析显示,血清FKN水平与FPG、2hPG、HbA1c、LDL-C、TG、TC、糖尿病病程呈正相关性(r=0.321、0.215、0.645、0.154、0.215、0.325、0.578,P0.05),与HDL-C呈负相关性(r=-0.547,P0.05);血清Apelin水平与FPG、2hPG、HbA1c、LDL-C、TG、TC、糖尿病病程呈正相关性(r=0.245、0.574、0.951、0.357、0.357、0.159、0.546,P0.05),与HDL-C呈负相关性(r=-0.459,P0.05);糖尿病病程、HbA1c、LDL-C、HDL-C、FKN和Apelin为DR病程的相关影响因素。结论:糖尿病伴发DR患者血清FKN、Apelin水平随着病程的加重逐渐增加,且这两种因子的水平与患者血糖、血脂代谢关系密切。  相似文献   

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目的:探讨糖化血红蛋(HbA1c)、空腹血糖(FPG)与2型糖尿病患者视网膜病变(DR)的相关性。方法:对我院2010年1月-2012年12月住院或门诊的336例2型糖尿病(T2DM)患者进行眼底检查或眼底血管荧光素造影检测,按有无视网膜病变分为视网膜病变(DR)组和无视网膜病变(NDR)组,并对HbA1c、FBG水平进行检测。结果:DR组较NDR组HbA1c水平高,差异有统计学意义(P〈0.05),HbA1c水平和DR分期呈正相关(I=0.526,P〈0.001),而DR组和NDR组FPG水平差异无无统计学意义(P〉0.05)。结论:可将HbA1c作为2型糖尿病患者视网膜病变发生和发展的监测指标之一。  相似文献   

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目的:通过比较短期胰岛素泵持续皮下胰岛素输注(CSⅡ)治疗前后初诊2型糖尿病(T2DM)患者血清C反应蛋白(C-reactive protein,CRP),胰岛素抵抗水平(Insulin Resistance,IR)和胰岛β细胞功能(β-cell function)的变化,评价CSⅡ对初诊T2DM患者CRP的改善情况.方法:对空腹血糖(FPG)>13mmol/L或餐后两小时血糖>15 mmol/L的初诊T2DM患者63例(男33例,女30例)行为期2周的CSⅡ治疗,并于治疗前后测定血清CRP、FPG、空腹胰岛素(FINS)、餐后两小时血糖(2hPG),对各指标进行分析.结果:1.治疗后CRP和HOMA-IR明显低于治疗前,差异均有统计学意义(P<0.01).2.治疗后HOMA-β明显高于治疗前,差异有统计学意义(P<0.01).3.CRP水平与FPG(r=0.26,P<0.05),HOMA-IR(r=0.21,P<0.05)呈正相关.结论:对伴有明显高血糖的初诊T2DM患者,CSⅡ治疗可以改善CRP水平和胰岛素抵抗.  相似文献   

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目的 探讨糖尿病(DM)患者阴道真菌菌群结构和生态分布特点.方法 采用真菌18S rDNA克隆文库法,对不同血糖控制情况下DM患者的阴道真菌18S rDNA序列进行克隆和测序,构建阴道真菌18S rDNA克隆文库,建立系统发育树,获取DM患者阴道真菌菌群的结构和组成特征.结果 DM患者和健康妇女阴道标本中存在3个真菌类群14个属共20个种系型的真菌菌群.健康妇女(H组)、HbA1c<6.5%患者(DMa组)、HbA1c6.5%~7.5%患者(DMb组)和HbA1c>7.5%患者(DMc组)的阴道真菌菌落分别存在7、9、13和16个OTUs.念珠菌属为各组研究对象阴道真菌菌群的优势菌属,其阳性克隆子在H组、DMa组、DMb组和DMc组的比例呈上升趋势.DM患者阴道白色念珠菌、光滑念珠菌和克柔念珠菌的比例不同程度升高,而阴道酿酒酵母菌和Uncultured fungi的比例显著降低(P<0.05),伴随其他一些真菌菌种的出现和比例改变.结论 DM患者阴道真菌菌群分子生态结构发生不同程度改变,DM患者阴道真菌菌群紊乱程度与血糖控制情况关系密切.  相似文献   

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目的:分析2型糖尿病(T2DM)患者血清低密度脂蛋白(LDL)、胱抑素C(CysC)与动脉粥样硬化(AS)的相关性。方法:选取2型糖尿病患者300名,根据颈动脉内膜中膜厚度分为非动脉粥样硬化斑块组(n=109)和动脉粥样硬化斑块组(n=191),并对动脉粥样硬化斑块的相关危险因素进行多因素Logistic回归分析。结果:(1)Pearson相关分析显示,LDL、CysC水平与IMT值呈正相关(P0.05)。(2)单因素分析示,非AS组和AS组两组间LDL(t=8.876,P0.05)、CysC(t=7.985,P0.05)、HbA1c(t=9.912,P0.05)、Hs-CRP(t=12.461,P0.05)、年龄(t=7.114,P0.05)、UA((t=8.618,P0.05)间差异有统计学意义;(3)多因素Logistic回归分析示,LDL、CysC、HbA1c、年龄是T2DM并AS的独立危险因素(P0.05);结论:LDL与CysC水平是T2DM并AS的独立危险因素。  相似文献   

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目的:评价胃转流术(RYGP)治疗非肥胖2型糖尿病(T2DM)的1年血糖代谢变化,并探讨术前T2DM病史对术后1年效果的影响。方法:收集我科2009年6月~2010年4月期间60例行RYGP的非肥胖T2DM患者术前及术后1年内的一般资料,临床及实验室检查数据等。根据T2DM病史分为两组:Ⅰ组:≤5年;Ⅱ组:5-10年,两组体质指数(BMI)均<30 kg/m2。术后6M、12M主要随访:空腹血糖(FPG)、餐后2h血糖(2hPG)、体重、BMI、糖化血红蛋白(HbA1c)、空腹血清胰岛素(Fins)、空腹C肽(C-P)、胰岛素抵抗指数和用药情况,采用SPSS17.0软件进行手术前后对照与组间对照分析。结果:与术前相比,Ⅰ组术后6M、12M时FPG,2hPG,体重,BMI,C-P,HbA1c,Fins均明显改善(P<0.05),HOMA-IR在术后6M无显著差异(P>0.05),术后12M有显著差异(P<0.05);Ⅱ组术后6M、12M时与术前相比,FPG,2hPG,体重,BMI,C-P,HbA1c,HOMA-IR均明显改善(P<0.05),Fins在术后6M、12M与术前相比无显著差异(P>0.05)。Ⅰ组和Ⅱ组于术后6M、12M在FPG、2hPG、体重、BMI、C肽、Fins、HbA1c、HOMA-IR、用药以及手术缓解率方面均无显著差异(P>0.05)。结论:非肥胖T2DM患者胃转流术后1年血糖代谢明显改善,术后完全缓解率逐步增高,术前T2DM病史(≤5年与5-10年)对术后1年效果的影响无显著差异。  相似文献   

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目的 研究老年2型糖尿病患者肠道菌群的变化,分析肠道菌群与糖化血红蛋白(HbA1c)的关系,为老年2型糖尿病患者血糖控制提供指导。方法 选择2019年1月至2020年1月我院169例老年2型糖尿病患者为研究对象,分为血糖控制良好组(67例,HbA1c<7.0%)及血糖控制不良组(102例,HbA1c≥7.0%),并选择同期83例健康老年志愿者为对照组,采用光冈法检测3组研究对象肠道菌群,分析肠道菌群变化与HbA1c关系。结果 对照组、血糖控制良好组以及血糖控制不良组对象肠道双歧杆菌、乳杆菌、拟杆菌数量依次降低,肠杆菌数量依次升高,任意组间差异均有统计学意义(均P<0.05);但肠球菌数量在3组间差异无统计学意义(均P>0.05)。2型糖尿病患者肠道双歧杆菌、乳杆菌数量与HbA1c水平呈负相关,相关系数分别为-0.431、-0.356,均有统计学意义(均P<0.05)。结论 2型糖尿病与肠道菌群紊乱相互影响,纠正肠道菌群紊乱对于2型糖尿病患者血糖控制有重要意义。  相似文献   

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目的系统评价益生菌制剂对2型糖尿病(T2DM)患者空腹血糖、脂质代谢以及应激反应的影响。方法计算机检索PubMed、Embase、The Cochrane Library、中国知网、维普期刊数据库和万方数据库。筛选关于糖尿病患者添加益生菌制剂相关性研究的中英文随机对照试验(RCT),进行纳入文献的资料提取和质量评价,采用RevMan 5.3软件进行Meta分析。对比益生菌组与对照组患者空腹血糖(FPG)、糖化血红蛋白(HbA1c)、甘油三酯(TG)、胆固醇(TC)和C反应蛋白(CRP)指标。结果共纳入17项符合标准的RCTs,Meta分析结果显示:与对照组患者相比,益生菌制剂可显著降低T2DM患者FPG (SMD=-0.43,95%CI:-0.57~-0.28,P0.00001)、HbA1c (SMD=-0.47,95%CI:-0.82~-0.12,P=0.009)和TG (SMD=-0.31,95%CI:-0.51~-0.11,P=0.002)水平;TC (SMD=-0.63,95%CI:-1.46~0.20,P=0.13)、CRP (SMD=-0.59,95%CI:-1.41~0.22,P=0.15)在两组患者之间差异无统计学意义。结论益生菌制剂可改善T2DM患者血糖、血脂状况。  相似文献   

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目的:研究糖化血红蛋白的检测在糖尿病患者中的诊断价值及对代谢指标的影响。方法:对126例临床确诊为糖尿痛患者进行糖化血红蛋白及空腹血糖检测,并且将糖化血红蛋白分为A组(HbA1c≤10%)和B组(HbA1c>10%),比较两组TG,TC,LDL.HD等指标。结果:FPG在B组患者的水平明显高于A组患者的水平,差异有显著的统计学意义(P<0.01),而2hPG,TC,LDL B组患者的水平明显高于A组患者的水平,差异有明显的统计学意义(P<0.05)。结论:检测糖化血红蛋白在糖尿病患者具有重要的临床价值。  相似文献   

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Defects in mitochondrial energy metabolism have been implicated in the pathology of several neurodegenerative disorders. In addition, the reactive metabolites generated from the metabolism and oxidation of the neurotransmitter dopamine (DA) are thought to contribute to the damage to neurons of the basal ganglia. We have previously demonstrated that infusions of the metabolic inhibitor malonate into the striata of mice or rats produce degeneration of DA nerve terminals. In the present studies, we demonstrate that an intrastriatal infusion of malonate induces a substantial increase in DA efflux in awake, behaving mice as measured by in vivo microdialysis. Furthermore, pretreatment of mice with tetrabenazine (TBZ) or the TBZ analogue Ro 4-1284 (Ro-4), compounds that reversibly inhibit the vesicular storage of DA, attenuates the malonate-induced DA efflux as well as the damage to DA nerve terminals. Consistent with these findings, the damage to both DA and GABA neurons in mesencephalic cultures by malonate exposure was attenuated by pretreatment with TBZ or Ro-4. Treatment with these compounds did not affect the formation of free radicals or the inhibition of oxidative phosphorylation resulting from malonate exposure alone. Our data suggest that DA plays an important role in the neurotoxicity produced by malonate. These findings provide direct evidence that inhibition of succinate dehydrogenase causes an increase in extracellular DA levels and indicate that bioenergetic defects may contribute to the pathogenesis of chronic neurodegenerative diseases through a mechanism involving DA.  相似文献   

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The lactate dehydrogenase activity in reactions of lactate oxidation and synthesis was studied in subfractions of the chicken brain, heart and liver at the embryonal, early postembryonal and adult stages of development after thyroxine administration. It has been shown that during embryogenesis thyroxine predominantly enhanced the rate of lactate oxidation in the mitochondrial tissues. A marked increase in the lactate synthesis was found in cytoplasm of the adult chicken tissues. Specificity of enzyme activity alterations was detected in the chicken brain during ontogenesis after thyroxine administration.  相似文献   

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In order to determine if the absence of vitamin C in the diet of capybaras (Hydrochoerus hydrochaeris) causes scurvy, a group of seven young individuals were fed food pellets without ascorbic acid, while another group of eight individuals received the same food with 1 g of ascorbic acid per animal per day. Animals in the first group developed signs of scurvy-like gingivitis, breaking of the incisors and death of one animal. Clinical signs appeared between 25 and 104 days from the beginning of the trial in all individuals. Growth rates of individuals deprived of vitamin C was considerably less than those observed in the control group. Deficiency of ascorbic acid had a severe effect on reproduction of another population of captive capybaras. We found that the decrease in ascorbic acid content in the diet affected pregnancy, especially during the first stages. The results obtained suggest that it is necessary to supply a suitable quantity of vitamin C in the diet of this species in captivity.  相似文献   

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Somatostatin (SST) peptide is a potent inhibitor of insulin secretion and its effect is mediated via somatostatin receptor 5 (SSTR5) in the endocrine pancreas. To investigate the consequences of gene ablation of SSTR5 in the mouse pancreas, we have generated a mouse model in which the SSTR5 gene was specifically knocked down in the pancreatic beta cells (betaSSTR5Kd) using the Cre-lox system. Immunohistochemistry analysis showed that SSTR5 gene expression was absent in beta cells at three months of age. At the time of gene ablation, betaSSTR5Kd mice demonstrated glucose intolerance with lack of insulin response and significantly reduced serum insulin levels. Insulin tolerance test demonstrated a significant increase of insulin clearance in vivo at the same age. In vitro studies demonstrated an absence of response to SST-28 stimulation in the betaSSTR5Kd mouse islet, which was associated with a significantly reduced SST expression level in betaSSTR5Kd mice pancreata. In addition, betaSSTR5Kd mice had significantly reduced serum glucose levels and increased serum insulin levels at 12 months of age. Glucose tolerance test at an older age also indicated a persistently higher insulin level in betaSSTR5Kd mice. Further studies of betaSSTR5Kd mice had revealed elevated serum C-peptide levels at both 3 and 12 months of age, suggesting that these mice are capable of producing and releasing insulin to the periphery. These results support the hypothesis that SSTR5 plays a pivotal role in the regulation of insulin secretion in the mouse pancreas.  相似文献   

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