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A novel susceptibility locus in MST1 and gene‐gene interaction network for Crohn's disease in the Chinese population 下载免费PDF全文
William K.K. Wu Rui Sun Tao Zuo Yuanyuan Tian Zhirong Zeng Jeffery Ho Justin C.Y. Wu Francis K.L. Chan Matthew T.V. Chan Jun Yu Joseph J.Y. Sung Sunny H. Wong Maggie H. Wang Siew C. Ng 《Journal of cellular and molecular medicine》2018,22(4):2368-2377
The incidence of Crohn's disease is increasing in many Asian countries, but considerable differences in genetic susceptibility have been reported between Western and Asian populations. This study aimed to fine‐map 23 previously reported Crohn's disease genes and identify their interactions in the Chinese population by Illumina‐based targeted capture sequencing. Our results showed that the genetic polymorphism A>G at rs144982232 in MST1 showed the most significant association (P = 1.78 × 10?5; odds ratio = 4.87). JAK2 rs1159782 (T>C) was also strongly associated with Crohn's disease (P = 2.34 × 10?4; odds ratio = 3.72). Gene‐gene interaction analysis revealed significant interactions between MST1 and other susceptibility genes, including NOD2, MUC19 and ATG16L1 in contributing to Crohn's disease risk. Main genetic associations and gene‐gene interactions were verified using ImmunoChip data set. In conclusion, a novel susceptibility locus in MST1 was identified. Our analysis suggests that MST1 might interact with key susceptibility genes involved in autophagy and bacterial recognition. These findings provide insight into the genetic architecture of Crohn's disease in Chinese and may partially explain the disparity of genetic signals in Crohn's disease susceptibility across different ethnic populations by highlighting the contribution of gene‐gene interactions. 相似文献
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Transcriptome sequencing reveals abundant olfactory genes in the antennae of the rice leaffolder,Cnaphalocrocis medinalis (Lepidoptera: Pyralidae) 下载免费PDF全文
Su Liu Wen‐Long Wang Yu‐Xing Zhang Bang‐Xian Zhang Xiang‐Jun Rao Xiao‐Ming Liu Dong‐Ming Wang Shi‐Guang Li 《Entomological Science》2017,20(1):177-188
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Li Huang Heng Dong Dong Zhou Ming Li Yanhong Liu Fang Zhang Yaoyao Feng Dongliang Yu Sue Lin Jiashu Cao 《The Plant journal : for cell and molecular biology》2018,94(1):203-209
The importance of long non‐coding RNAs (lncRNAs) in plant development has been established, but a systematic analysis of lncRNAs expressed during pollen development and fertilization has been elusive. We performed a time series of RNA‐seq experiments at five developmental stages during pollen development and three different time points after pollination in Brassica rapa and identified 12 051 putative lncRNAs. A comprehensive view of dynamic lncRNA expression networks underpinning pollen development and fertilization was provided. B. rapa lncRNAs share many common characteristics of lncRNAs: relatively short length, low expression but specific in narrow time windows, and low evolutionary conservation. Gene modules and key lncRNAs regulating reproductive development such as exine formation were uncovered. Forty‐seven cis‐acting lncRNAs and 451 trans‐acting lncRNAs were revealed to be highly coexpressed with their target protein‐coding genes. Of particular importance are the discoveries of 14 lncRNAs that were highly coexpressed with 10 function‐known pollen‐associated coding genes. Fifteen lncRNAs were predicted as endogenous target mimics for 13 miRNAs, and two lncRNAs were proved to be functional target mimics for miR160 after experimental verification and shown to function in pollen development. Our study provides the systematic identification of lncRNAs during pollen development and fertilization in B. rapa and forms the foundation for future genetic, genomic, and evolutionary studies. 相似文献
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Comparative transcriptome analysis provides insights of anti‐insect molecular mechanism of Cassia obtusifolia trypsin inhibitor against Pieris rapae 下载免费PDF全文
Mian Xiang Xian Zhang Yin Deng Yangyang Li Jihua Yu Jianquan Zhu Xinhe Huang Jiayu Zhou Hai Liao 《Archives of insect biochemistry and physiology》2018,97(1)
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