共查询到20条相似文献，搜索用时 656 毫秒
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BERCEL NA 《California medicine》1955,82(2):107-110
Animal experiments having indicated a nearly twofold increase in anticonvulsant protection with the use of diuretics which increase blood-brain barrier permeability, the principle was applied to treatment of humans with epilepsy. The addition of diuretics to anticonvulsant medication permitted a decrease of previously toxic dosages in ten epileptics, followed for six months, without lessening (and in some cases improving) the control of seizures. In three cases excessive diuresis and gastric distress necessitated discontinuance or decrease in dosage of the diuretic used. 相似文献
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POPKIN RJ 《California medicine》1954,80(4):291-293
Three hundred patients with the post-thrombophlebitic syndrome were studied. The lower extremities were involved in the majority of cases. Severe disabling subjective symptoms, such as burning, aching, cramping and shooting pains, occurred in approximately 15 per cent of cases regardless of the presence or absence of objective findings such as ulcerations, edema or dermatitis. Subjective symptoms occurred in about as many men as women. The persistence and severity of disabling subjective symptoms seemed to be unrelated to the possibility of compensation or pecuniary gain. No adequate explanation could be found for the perseverance of disabling subjective symptoms. There was no consistent relation of subjective symptoms and disability to psychic factors. 相似文献
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Natalia Mota-Martorell Irene Pradas Mariona Jové Alba Naudí Reinald Pamplona 《Revista espa?ola de geriatría y gerontología》2019,54(2):88-93
Background
The glycerophospholipids, synthesised from diacylglycerol (DAG), are one of the main lipid components of cell membranes. The lipid profile is an optimised feature associated with animal longevity. In this context, the hypothesis is presented that the DAG biosynthesis rate, and thus, the glycerophospholipids content, is related to animal longevity.Material and methods
A plasma lipidomic analysis was performed based on the mass spectrometry of 11 mammalian species with a maximum longevity ranging from 3.5 to 120 years. Lipid identification was based on exact mass, retention time, and isotopic distribution. ANOVA test was applied to differentiate the lipids between animal species. The relationship between these lipids and longevity was carried out with a Spearman correlation. Data was analysed using SPSS and MetaboAnalyst.Results
Among the 1,061 different lipid molecular species found between species, 47 were defined as DAG. Interestingly, 14 of them showed a negative correlation with mammalian maximum longevity. Multivariate statistics revealed that 14 DAGs were enough to define mammalian species and their maximum longevity.Conclusions
Data suggest that long-lived mammalian species have a lower rate of glycerophospholipids synthesis through the de novo pathway, possibly associated with a lower rate of membrane lipid exchange, which in turn is related to lower energy expenditure. 相似文献11.
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SHELTON JT 《California medicine》1955,82(5):388-391
Mental retardation is a symptom of an underlying disease process. In California state hospitals for the retarded an accurate dynamic diagnosis is possible through utilizing the knowledge of neurology, psychiatry, pediatrics, psychology, social service, rehabilitation, education, the laboratory and trained psychiatric technicians. A program of "custody" is archaic and we are returning to the concept of training, treatment, and turnover. This kind of program is essential in order to avoid building new hospitals at the cost of millions of dollars every few years.Parent organizations for retarded children are expanding in ever increasing number. Special education programs in public schools, foster care homes and sheltered workshops may make admission to hospitals unnecessary and aid return of patients to the community. 相似文献
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