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1.
The relationship between advancing age in adults and patterns of cortical bone maintenance has been extensively documented for archaeological populations (Dewey, et al., 1969; Van Gerven et al., 1969; Perzigian, 1973). Most recently, this research has been expanded to include a more thorough consideration of the geometric properties of bone in relationship to adult age changes (Martin and Atkinsin, 1977; Ruff and Hayes, 1983). To date, however, few studies have documented subadult patterns of cortical bone maintenance in archaeological populations and none have incorporated the relationship between patterns of cortical bone loss and gain and the changing geometric properties of growing bone. Using a sample of 172 tibias from children excavated from the Medieval Christian site of Kulubnarti, located in Nubia's Batn el Hajar, the present research examines the relationship between percent cortical area, bone mineral content, and cross-sectional moments of inertia. Among these children, bone mineral content increases steadily from birth in spite of a reduction in percent cortical area during early and late childhood. It appears, therefore, that tissue quality of the bone is not adversely affected by the reduction. Furthermore, the reduction in percent cortical area in later childhood corresponds to a dramatic increase in bending strength measured by cross-sectional moments of inertia. Thus, whether this cortical reduction is due entirely or in part to either normal modeling or nutritional stress, the tissue and organ quality of the bone is not adversely affected. 相似文献
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Dennis P. van Gerven Rosemary Beck James R. Hummert 《American journal of physical anthropology》1990,82(4):413-420
Analysis of enamel hypoplasia frequencies for two medieval populations representing the earliest and latest Christian periods of ancient Nubia reveals important diachronic shifts in childhood stress. The mean frequency for hypoplastic bands among the early Christians is 4.2, while the late Christian sample has a mean frequency of 3.7. In addition, the earlier Christians show a prolongation of hypoplastic occurrences through childhood corresponding to a prolonged period of intensified childhood mortality. The modal time interval between hypoplastic occurrences is also shorter for the early Christian children. A comparison of hypoplasia frequencies by sex also reveals a pattern of considerable interest. Females show both lower frequencies of hypoplasias as well as a delay in onset. The diachronic differences are consistent with other indications from paleopathology and paleodemography that childhood stress decreased in later Christian times. The sex differences suggest that during the infancy and early childhood females were more resilient than their male counterparts. 相似文献
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This study examined the efficacy of bilateral asymmetry in epiphyseal union as an indicator of environmental stress affecting the skeleton. We compared the extent of asymmetry in the postcranial skeleton between two cemetery samples excavated from Medieval Kulubnarti, Sudanese Nubia. Past studies have strongly suggested that these ancient Nubians experienced environmental stress-the early Christian period (550-750 AD) population to a greater extent than the late Christian period (750-1450 AD) population. We hypothesized that if bilateral asymmetry is a reflection of stress, then it should be present or greater in the more stressed population, the early Christian period population, while absent or found to a lesser extent in the less stressed population, the late Christian period population. We computed two mean values, representative of right-side and left-side epiphyseal union, for each individual in both cemetery samples, and tested for significant differences. Bilateral asymmetry was significant in the combined cemetery sample of 90 individuals (P < 0.019). When cemetery samples were tested separately, bilateral asymmetry was significant for the early Christian period sample (P < 0.001), but not for the late Christian period sample. There were no differences attributable to sex. Finally, we discuss why we conclude that environmental stress was favored over a biomechanic explanation as the cause for asymmetry. To the extent that our results support previous findings that early Christian period individuals were more affected by environmental stress than late Christian period individuals, it is reasonable to consider bilateral asymmetry in skeletal growth and maturation a good indicator of environmental stress. 相似文献
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Long bone growth variation among skeletal samples has had limited application to ecological studies of archaeological groups, in spite of its well-known sensitivity to health and nutritional status. In this study we examine long bone growth variation among ten samples of Arikara skeletal groups, all located in the Middle Missouri subarea of South Dakota and ranging in time from A.D. 1600 to 1832. The samples are analyzed by variant, an archaeological taxonomic unit below Tradition. Children's long bones between about 0.5 and 11.9 years of age were analyzed by means of regression using the model, bone length =b0 + b1 (age) + b2 (log10 age). The three variants, Extended Coalescent, Postcontact Coalescent, and Disorganized Coalescent, differ from one another with regard to health and nutritional status. Extended Coalescent groups probably experienced periods of undernutrition due to unfavorable climatic conditions prevailing at the time. Postcontact Coalescent groups experienced more favorable health and nutrition due to improved climatic conditions and introduction of the horse. Disorganized Coalescent groups were exposed to undernutrition and high levels of morbidity, due to introduction of epidemic diseases, depopulation, and intertribal conflict. Analysis of slopes shows significant heterogeneity among variants for humerus, radius, and tibia, but not femur. In general, the Postcontact Coalescent is characterized by slighter greater rates of increase with age and longer bone lengths for each age than is Extended Coalescent. Disorganized Coalescent exhibits lower rates of increase, particularly in later childhood, with shorter bone lengths in late childhood. Disorganized Coalescent also presents longer radius and humerus lengths than the other two variants in early childhood, an unexpected finding. This may be partly, but not entirely, explained by differential bone response to stress along the lines of maturity gradients. 相似文献
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Simon Mays Rachel Ives Megan Brickley 《American journal of physical anthropology》2009,140(3):410-416
Endochondral growth, appositional growth, and acquisition of cortical bone thickness in the femur are investigated in subadult skeletons (N = 43, dental age range birth to 12 years) from the 19th‐century AD burial site of St. Martin's churchyard, Birmingham, England. Endochondral growth is monitored using diaphyseal femoral length. Appositional growth is monitored using radiographic midshaft mediolateral width and acquisition of cortical bone using combined mediolateral cortical thickness measured at the midshaft from radiographs. The methodology involves plotting these variables against dental age. Growth is compared in children of differing socioeconomic status. Higher and lower status individuals are identified in the assemblage by their burial in brick vaults in the case of the former and in earth‐cut graves in the case of the latter. The relationships between bone dimensions and dental age are described using a polynomial regression procedure, and analysis of regression residuals is used to evaluate differences in bone dimension‐for‐dental age between the two status groups. Results show that lower socioeconomic status individuals had lower cortical thickness‐for‐dental age than those of higher status. This was interpreted as likely reflecting poorer nutrition in the children of lower socioeconomic backgrounds. There was no patterning with respect to socioeconomic status in femur diaphyseal length or midshaft width. The results support the idea that, for skeletal populations, growth in cortical thickness may be a more sensitive indicator of adverse conditions in childhood than growth in bone length or width. Am J Phys Anthropol, 2009. © 2009 Wiley‐Liss, Inc. 相似文献
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Setup of a bone aging experimental model in the rabbit comparing changes in cortical and trabecular bone: Morphological and morphometric study in the femur 下载免费PDF全文
Ugo E. Pazzaglia Valeria Sibilia Terenzio Congiu Francesca Pagani Marco Ravanelli Guido Zarattini 《Journal of morphology》2015,276(7):733-747
Bone aging was studied in an experimental model (rabbit femur) in three populations aged 0.5, 1.5, and 7.5 years. Cortical bone histology was compared with a data set from a 1.5‐month‐old population of an earlier published paper. From 0.5‐year‐old onward, the mean femur length did not increase further. Thereafter, the mean marrow area increased and the cortical area decreased significantly with aging. This was associated with a structural pattern transformation from plexiform to laminar and then Haversian‐like type. The distal meta‐epiphysis bone trabecular density of the oldest populations also was significantly lower in specific regions of interest (ROI). Percentage sealed primary vascular canals in laminar bone significantly increased with aging without variation of percentage sealed secondary osteons. Remodeling rate reflected by the density of cutting cones did not significantly change among the age populations. These data suggest that laminar bone vascular pattern is more functional in the fast diaphyseal expansion but not much streamlined with the renewal of blood flow during secondary remodeling. Bone aging was characterized by: 1) secondary remodeling subendosteally; 2) increment of sealed primary vascular canals number; 3) increased calcium content of the cortex; 4) cortical and trabecular bone mass loss in specific ROIs. Taken together, the present data may give a morphological and morphometric basis to perform comparative studies on experimental models of osteoporosis in the rabbit. J. Morphol. 276:733–747, 2015. © 2015 Wiley Periodicals, Inc. 相似文献
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This study aimed to investigate effects of restricted calcium intake on cortical and trabecular bone density in white rats. Low Ca diet was fed for six weeks, and bone density and bone metabolism parameters were assessed in blood. This study was carried out on 12 male white rats aged 12 weeks (Sprague-Dawley; SD). These rats were bred for 1 week and randomly assigned to the standard calcium diet group (SCa group, n = 6) and the low calcium diet group (LCa group; n = 6). The SCa group was given a modified AIN-93M mineral mix (with 0.5% Ca), which was made by adding calcium to a standard AIN93 diet, and the LCa Group was fed a modified AIN-93 Mineral mix (with 0.1% Ca). Femoral BMD and BMC were measured by DEXA in each rat. After trabecular bone was separated from cortical bone, volumetric bone mineral density (vBMD) was measured using pQCT. Serum Ca and P levels were measured as parameters of bone metabolism, and S-ALP, S-TrACP and-Dpd levels were also measured. The results revealed no significant differences in weight, growth rate, feed consumption and feed efficiency between the two groups before and after calcium-restricted diet (p > .05). No significant differences were also observed in bone length and bone mass between the two groups (p > .05). Although bilateral femoral BMDs were not significantly different between the two groups, bilateral femoral BMCs significantly decreased in the LCa group, compared with the SCa group (p = .023, p = .047). Bilateral cortical MDs were not significantly different between the two groups, either. However, trabecular BMD significantly decreased in the LCa group, compared with the SCa group (p = .041). U-Dpd and S-TrACP levels significantly declined in the LCa group, compared to the SCa group (p = .039, p = .010). There were no significant differences in serum Ca and P levels between the two groups (p > .05). However, a significant decrease in urinary Ca level (p = .001) and a significant increase in urinary P (p = .001) were observed in the LCa group, compared to the Sca group. These findings described that six-week low calcium diet led to decreased trabecular bone density, reduced urinary excretion of Ca and increased urinary excretion of P. As a result, Ca hemeostasis can be maintained. 相似文献
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Christopher B. Ruff Evan Garofalo Megan A. Holmes 《American journal of physical anthropology》2013,150(1):29-37
The study of juvenile skeletal remains can yield important insights into the health, behavior, and biological relationships of past populations. However, most studies of past skeletal growth have been limited to relatively simple metrics. Considering additional skeletal parameters and taking a broader physiological perspective can provide a more complete assessment of growth patterns and environmental and genetic effects on those patterns. We review here some alternative approaches to ontogenetic studies of archaeological and paleontological skeletal material, including analyses of body size (stature and body mass) and cortical bone structure of long bone diaphyses and the mandibular corpus. Together such analyses can shed new light on both systemic and localized influences on bone growth, and the metabolic and mechanical factors underlying variation in growth. Am J Phys Anthropol, 2013. © 2012 Wiley Periodicals, Inc. 相似文献
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Gloria Y'Edynak 《American journal of physical anthropology》1976,45(3):569-574
The pattern of long bone growth in Eskimo and Aleut juvenile skeletons reflects that in living Eskimos and Aleuts. There is a pre-adolescent growth spurt which is particularly intense in females. After age 14 male long bones supercede those of females in length. The characteristic Eskimo and Aleut adult body proportion is established early in childhood. Eskimos and Aleuts have shorter bones than whites at all ages. The difference in length of the forearm and lower leg in comparison with whites appears to increase especially at adolescence. 相似文献
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Rats were exposed to a 60-Hz electric field at an unperturbed field strength of 100 kV/m to determine its affect on bone growth and fracture repair. Exposure of immature male and female rats for 20 h/day for 30 days did not alter growth rate, cortical bone area, or medullary cavity area of the tibia. In another experiment, midfibular osteotomies were performed and the juvenile rats were exposed at 100 kV/m for 14 days. Evaluation by resistance to deformation and breaking strength indicated that fracture repair was not as advanced in the exposed animals as in the sham-exposed animals. In another experiment measurements of resistance to deformation were made in adult rats at 16, 20, and 26 days after osteotomy. Fracture repair was slower in exposed compared to control animals at day 20 and, to a lesser extent, at day 16, but not at day 26. 相似文献
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Abstract: Patterns of bone deposition are reported and deduced from mid‐shaft sections of 21 limb bones of the dicynodont Placerias hesternus from the Placerias Quarry (Upper Triassic), Arizona, USA. All sampled elements of P. hesternus have a large medullary cavity completely filled with bony trabeculae surrounded by dense cortical bone. Dense Haversian bone extends from the perimedullary region to at least the mid‐cortex in all sampled bones. Primary bone in the outer cortex of limb elements of P. hesternus is generally zonal fibrolamellar with a peripheral layer of parallel‐fibred bone. These data suggest periodic rapid osteogenesis followed by slower growth. Among dicynodonts, this strategy is most similar to growth previously reported in other Triassic (Lystrosaurus, Wadiasaurus) and some Permian taxa (Oudenodon, Tropidostoma). An external fundamental system (EFS), suggesting complete or near complete cessation of appositional growth, is present in the largest tibia. This is the first report of EFS in dicynodonts and may represent the attainment of maximum size in P. hesternus. Slow‐growing peripheral bone was observed in elements of varying size in our sample and may support a differential growth pattern between P. hesternus individuals from this locality. A complete growth series of P. hesternus, analysis of Placerias specimens from other localities, and further sampling of other Upper Triassic dicynodonts are needed to better understand a more complete picture of the growth and remodelling patterns that we have initially investigated. 相似文献
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【背景】矿区废渣堆重金属污染严重,废渣堆分布着一些耐重金属的微生物。【目标】探究重金属胁迫对真菌生长及发酵液pH的影响。【方法】从金川矿区废渣堆采集土样,分离培养具有产酸能力的真菌,采用形态学与分子生物学技术鉴定这些菌株,并测定其产酸能力及其对Pb~(2+)、Cd~(2+)和Zn~(2+)的耐受性。【结果】形态学及18S rRNA基因序列分析获得黑曲霉ZJ-I (Aspergillus niger ZJ-I)和产黄青霉ZJ-V (Penicilium chrysogenum ZJ-V)两个产酸菌株。未加重金属培养时,与不接种真菌对照相比,上述2个菌株的发酵液pH分别下降0.58和0.69;添加重金属处理后,随着重金属浓度的增加,pH变化幅度变小,不同浓度Pb~(2+)使A.nigerZJ-I发酵液pH值分别下降0.53、0.39、0.34和0.39,使P. chrysogenum ZJ-V发酵液pH值分别下降0.21、0.23、0.14和0.09;不同浓度Cd~(2+)使A. niger ZJ-I发酵液pH值分别下降0.75、0.43、0.39和0.32,使P. chrysogenum ZJ-V发酵液pH值分别下降0.62、0.46、0.38和0.49;不同浓度Zn~(2+)可使A.nigerZJ-I发酵液pH分别下降0.87、0.61、0.57和0.43,使P. chrysogenum ZJ-V发酵液pH分别下降1.1、0.34、0.44和0.49;低浓度的Zn~(2+)对菌株A.niger ZJ-I和P. chrysogenum ZJ-V产酸都有促进作用,低浓度的Cd~(2+)对A. niger ZJ-I产酸有促进作用。当Cd~(2+)、Zn~(2+)与Pb~(2+)的浓度分别超过200、400、2 000 mg/L时,3种不同浓度的重金属对菌株A. niger ZJ-I的抑制率达到80%以上,抑制效果显著;当Cd~(2+)、Zn~(2+)与Pb~(2+)浓度分别超过200、1 000、2 000 mg/L时,3种不同浓度的重金属对菌株P.chrysogenumZJ-V抑制率达到80%以上,抑制效果显著。【结论】两株真菌均具有产酸能力和一定的重金属耐受性,菌株P. chrysogenum ZJ-V发酵液产酸性能与重金属耐受能力都要优于ZJ-I,菌株ZJ-V具备潜在的淋洗重金属污染土壤的能力。 相似文献
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Damage and recovery of the bone growth mechanism in young rats following 5-fluorouracil acute chemotherapy 总被引:2,自引:0,他引:2
Chemotherapy-induced bone growth arrest and osteoporosis are significant problems in paediatric cancer patients, and yet how chemotherapy affects bone growth remains unclear. This study characterised development and resolution of damage caused by acute chemotherapy with antimetabolite 5-fluorouracil (5-FU) in young rats in the growth plate cartilage and metaphyseal bone, two important tissues responsible for bone lengthening. In metaphysis, 5-FU induced apoptosis among osteoblasts and preosteoblasts on days 1-2. In growth plate, chondrocyte apoptosis appeared on days 5-10. Interestingly, Bax was induced prior to apoptosis and Bcl-2 was upregulated during recovery. 5-FU also suppressed cell proliferation on days 1-2. While proliferation returned to normal by day 3 in metaphysis, it recovered partially on day 3, overshot on days 5-7 and normalised by day 10 in growth plate. Histologically, growth plate heights decreased by days 4-5 and returned normal by day 10. In metaphysis, primary spongiosa height was also reduced, mirroring changes in growth plate thickness. In metaphyseal secondary spongiosa, a reduced bone volume was observed on days 7-10 as there were fewer but more separated trabeculae. Starting from day 4, expression of some cartilage/bone matrix proteins and growth factors (TGF-beta1 and IGF-I) was increased. By day 14, cellular activity, histological structure and gene expression had returned normal in both tissues. Therefore, 5-FU chemotherapy affects bone growth directly by inducing apoptosis and inhibiting proliferation at growth plate cartilage and metaphyseal bone; after the acute damage, bone growth mechanism can recover, which is associated with upregulated expression of matrix proteins and growth factors. 相似文献
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Differentiation and growth of bone ornamentation in vertebrates: A comparative histological study among the Crocodylomorpha 下载免费PDF全文
V. de Buffrénil F. Clarac M. Fau S. Martin B. Martin E. Pellé M. Laurin 《Journal of morphology》2015,276(4):425-445
Bone ornamentation, that is, hollow (pits and grooves) or protruding (ridges) repetitive reliefs on the surface of dermal bones, is a frequent, though poorly studied and understood, feature in vertebrates. One of the most typical examples of this characteristic is given by the Crurotarsi, a taxon formed by the crocodilians and their closest allies, which generally display deep ornamentation on skull roof and osteoderms. However, the ontogenetic process responsible for the differentiation and development of this character remains controversial. This study was conducted to settle the question on histological and microanatomical evidence in several crurotarsan taxa. Observational and experimental data in extant and extinct crocodyliforms show that bone ornamentation is initially created, and later maintained during somatic growth (that is indefinite in crocodilians), by a complex process of bone remodeling comprising local resorption of superficial bone cortices, followed by partial reconstruction. The superficial reliefs of crocodilian dermal bones are thus permanently modified through pit enlargement, drift, stretching, shrinking, or complete filling. Ridges are also remodeled in corresponding ways. These processes allow accommodation of unitary ornamental motifs to the overall dimensions of the bones during growth. A parsimony optimization based on the results of this study, but integrating also published data on bone histology in non‐crocodyliform crurotarsans and some non‐crurotarsan taxa, suggests that the peculiar mechanism described above for creating and maintaining bone ornamentation is a general feature of the Crurotarsi and is quite distinct from that attributed by previous authors to other vertebrates. J. Morphol. 276:425–445, 2015. © 2014 Wiley Periodicals, Inc. 相似文献
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将能源植物用作矿区生态修复物种,对矿区的经济发展和生态环境具有重要意义。以能源植物柳枝稷为研究对象,通过盆栽试验,分析其在对照、轻度、中度以及重度干旱胁迫下柳枝稷幼苗在矿区土壤基质和非矿区土壤基质下的生长特性,并结合不同干旱胁迫下矿区土壤基质中种子萌发特征,揭示柳枝稷对干旱胁迫的响应机制和对矿区土壤的生态适应性。试验结果表明:(1)柳枝稷种子发芽总数、发芽率、发芽势以及发芽指数在轻度胁迫下达到最大值,活力指数在对照组最高,而在重度胁迫下,各项指标均达到最小值;种苗各生长指标在轻度胁迫下最小,幼苗根长和鲜重在重度胁迫下最高,芽长和芽重在其余三组胁迫下相差不大。(2)干旱胁迫使两种土壤基质下的柳枝稷株高降低,枯叶率增加,在对照、轻度胁迫和重度胁迫下能够保持叶片水分含量和分蘖数稳定;矿区土壤基质中,柳枝稷根体积在轻度胁迫下最大,中度胁迫下根长最长,重度胁迫下根数最多;根冠比随着干旱胁迫的加剧表现出先减后增的趋势,在轻度胁迫下最小,在重度胁迫下最大。(3)与非矿区土壤基质相比,柳枝稷在矿区土壤基质下根冠比更大,其余生长指标均更小;随着干旱胁迫的加剧,柳枝稷在矿区土壤基质下的株高、枯叶率、叶片相... 相似文献
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Bone strength traits in chickens are gaining importance due to economic losses and welfare concerns associated with bone fractures and other abnormalities. A chicken F2 resource population was generated from layer and broiler genetic lines, and traits relating to bone strength, egg production, egg quality and growth rate were measured in approximately 500 F2 hens. Four biological candidate genes (vitamin D receptor, VDR; insulin, INS; insulin-like growth factor 1, IGF1; and osteopontin, SPP1) were selected for investigation. Single nucleotide polymorphisms (SNPs) were identified for each candidate gene by comparing sequences between grandparent lines. Polymerase chain reaction restriction-fragment length polymorphism or SNaPshot assays were developed to genotype the F2 population and to evaluate associations between each SNP genotype and multiple phenotypes. Significant associations (P < 0.0125) were found between VDR and bone mineral content of the humerus at 35 weeks of age; between IGF1 and SPP1 and 5-week body weight; and between INS and 55-week body weight. 相似文献
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Insulin‐like growth factor binding protein 4 inhibits proliferation of bone marrow mesenchymal stem cells and enhances growth of neurospheres derived from the stem cells 下载免费PDF全文
Huiwen Li Shukui Yu Fei Hao Xiaohong Sun Junpeng Zhao Qunyuan Xu Deyi Duan 《Cell biochemistry and function》2018,36(6):331-341
Insulin‐like growth factor binding protein 4 (IGFBP‐4) was reported to trigger cellular senescence and reduce cell growth of bone marrow mesenchymal stem cells (BMSCs), but its contribution to neurogenic differentiation of BMSCs remains unknown. In the present study, BMSCs were isolated from the femur and tibia of young rats to investigate effects of IGFBP‐4 on BMSC proliferation and growth of neurospheres derived from BMSCs. Bone marrow mesenchymal stem cell proliferation was assessed using CCK‐8 after treatment with IGFBP‐4 or blockers of IGF‐IR and β‐catenin. Phosphorylation levels of Akt, Erk, and p38 in BMSCs were analysed by Western blotting. Bone marrow mesenchymal stem cells were induced into neural lineages in NeuroCult medium; the number and the size of BMSC‐derived neurospheres were counted after treatment with IGFBP‐4 or the blockers. It was shown that addition of IGFBP‐4 inhibited BMSC proliferation and immunodepletion of IGFBP‐4 increased the proliferation. The blockade of IGF‐IR with AG1024 increased BMSC proliferation and reversed IGFBP‐4‐induced proliferation inhibition; however, blocking of β‐catenin with FH535 did not. p‐Erk was significantly decreased in IGFBP‐4‐treated BMSCs. IGFBP‐4 promoted the growth of neurospheres derived from BMSCs, as manifested by the increases in the number and the size of the derived neurospheres. Both AG1024 and FH535 inhibited the formation of NeuroCult‐induced neurospheres, but FH535 significantly inhibited the growth of neurospheres in NeuroCult medium with EGF, bFGF, and IGFBP‐4. The data suggested that IGFBP‐4 inhibits BMSC proliferation through IGF‐IR pathway and promotes growth of BMSC‐derived neurospheres via stabilizing β‐catenin. 相似文献