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Abakay A Gokalp O Abakay O Evliyaoglu O Sezgi C Palanci Y Ekici F Karakus A Tanrikulu AC Ayhan M 《Biological trace element research》2012,145(2):151-157
The aim of this study was to investigate the respiratory function disorders that could be related to dust exposure during
the production of copper mine in copper mineworkers (CMWs). The study included 75 male CMWs (mean age, 32.0 ± 7.1 years, 58.6%
smokers) and 75 male age- and smoking status-matched healthy control subjects. Serum Cu level was significantly higher in
the CMW group (0.80 ± 0.62 μg/ml) than the control group (0.60 ± 0.39 μg/ml) (p = 0.017). Significant negative correlations were found between serum Cu level and forced expiratory volume in first second
(r = −0.600; p < 0.001) and between serum Cu level and forced vital capacity (r = −0.593; p = <0.001) in CMWs. Serum Cu level was significantly higher in the restrictive type pulmonary function disorders group (1.36 ± 0.62 μg/ml)
than obstructive type (0.90 ± 0.55 μg/ml) and normal pulmonary function pattern group (0.53 ± 0.43 μg/ml) (p < 0.001). Patients with radiological parenchymal abnormalities had significantly higher serum copper levels than those without
abnormalities (1.53 ± 0.52 vs. 0.71 ± 0.52 μg/ml, respectively; p = 0.002). In conclusion, result of the study has shown a negative association between pulmonary functions disorders and radiological
abnormalities and serum Cu levels in CMWs. 相似文献
3.
Manuel Olivares Fernando Pizarro Daniel López de Romaña Manuel Ruz 《Biological trace element research》2010,136(2):180-186
To measure the effect of acute copper (Cu) administration, given as an aqueous solution, on the absorption of iron (Fe), 29
healthy adult women participated in two iron absorption studies. Subjects received 0.5 mg of Fe, as ferrous sulfate, alone
or with Cu, as copper sulfate, at 0.5:1, 1:1, or 2:1 Cu/Fe molar ratios (study I) or at 4:1, 6:1, or 8:1 Cu/Fe molar ratios
(study II) as an aqueous solution on days 1, 2, 14, and 15 of the study. Fe absorption was assessed by erythrocyte incorporation
of iron radioisotopes 55Fe and 59Fe. Geometric mean (range ± SD) absorption of Fe alone or at 0.5:1, 1:1, 2:1 Cu/Fe molar ratios were 34.4% (17.3–68.5%), 40.9%
(24.9–67.2%), 48.3% (24.8–94.1%), and 50.2% (25.3–99.5%), respectively (ANOVA, p = 0.12). Geometric mean (range ± SD) absorption of Fe alone or at 4:1, 6:1, 8:1 Cu/Fe molar ratios were 28.7% (12.1–67.9%),
21.5% (6.5–71.5%), 29.6% (10.3–85.4%), and 36.5% (18.3–73.1%), respectively (ANOVA, p = 0.16). In conclusion, combined Cu and Fe administration in an aqueous solution does not inhibit Fe bioavailability. This
information could help in the design of rational guidelines for copper and iron supplementation programs. Our results support
the hypothesis that divalent metal transporter 1 is not physiologically relevant for copper absorption in humans. 相似文献
4.
Andreazza R Okeke BC Pieniz S Brandelli A Lambais MR Camargo FA 《Biological trace element research》2011,143(2):1182-1192
Environmental copper contamination is a serious human health problem. Copper reductase is produced by microorganisms to facilitate
copper uptake by ATPases into the cells increasing copper biosorption. This study assessed the reduction of Cu(II) by cell-free
extracts of a highly copper-resistant bacterium, Pseudomonas sp. strain NA, isolated from vineyard soil contaminated with copper. Both intact cells and cell-free extract of Pseudomonas sp. strain NA displayed substantial reduction of Cu(II). Intact cells reduced more then 80 mg L−1 of Cu(II) from medium amended with 200 mg L−1 of copper after 24 h of incubation. Cell-free extract of the isolate reduced more than 65% of the Cu(II) at initial copper
concentration of 200 mg L−1 after 24 h. Soluble protein production was high at 72 h of incubation at 100 mg L−1 of copper, with more then 60 μg L−1 of total soluble protein in cell-free extract recorded. Cu(II) reduction by isolate NA was increased when copper concentration
increased for both intact cells and cell-free extract. Results indicate that Pseudomonas sp. strain NA produces copper reductase enzyme as the key mechanism of copper biotransformation. 相似文献
5.
Ersoy IH Koroglu BK Varol S Ersoy S Varol E Aylak F Tamer MN 《Biological trace element research》2011,143(2):619-624
Although there are many studies on effect of fluoride on trace elements in experimental animals, few studies exist on serum
trace elements levels in patients with endemic fluorosis. We aimed to determine the serum levels of trace elements including
serum copper (Cu), zinc (Zn), and serum levels of minerals including calcium (Ca), phosphorus (P), magnesium (Mg), sodium
(Na), potassium (K) in patients with endemic fluorosis. The study group consisted of 30 patients with endemic fluorosis (17
females, 13 males, mean age 33.53 ± 9.85 years). An age, gender, and body mass index matched 30 healthy volunteers comprised
control group (21 females, ten males with a mean age 33.93 ± 7.39 years). Urine fluoride levels of chronic fluorosis patients
were significantly higher than that of control subjects as expected (1.92 ± 0.10 mg/l vs. 0.41 ± 0.09 mg/l, respectively;
P < 0.001). Serum Cu levels (89.14 ± 16.77 μg/dL vs. 102.69 ± 25.04 μg/dL, respectively, P = 0.017), serum Zn levels (77.98 ± 20.58 μg/dL vs. 94.57 ± 35.87μg/dL, respectively, P = 0.032), and serum Mg levels (1.92 ± 0.18 mg/dL vs. 2.07 ± 0.31 mg/dL, respectively, p = 0.022) was significantly lower in chronic fluorosis patients than in controls. There were no statistically significant
differences between the fluorosis group and control group with respect to serum levels of Na, K, Ca, and P. We concluded that
chronic fluorosis is associated with reduced serum levels of Cu, Zn, and Mg. 相似文献
6.
Fatemi Naieni F Ebrahimi B Vakilian HR Shahmoradi Z 《Biological trace element research》2012,146(1):30-34
Premature graying of hair with unclear etiology, which is known as premature canities, is a common cause of referrals to the
dermatologists. We assessed the relationship between serum iron, copper, and zinc concentrations with premature canities.
This study was conducted on patients under 20 years old suffering from premature canities, having a minimum of ten gray hair
fibers, and referring to university hospitals of Isfahan (Iran). The results were compared with age–sex-matched controls.
Demographic data and disease characteristics were recorded for two groups. We studied serum iron, copper, and zinc concentrations
of 66 patients and 66 controls using atomic absorption and Ferrozine methods. The mean age of studied cases was 17.8 ± 2.0 years,
and the mean age of the onset of canities was 15.5 ± 3.2 years with no significant difference between males and females (P > 0.05). Serum copper concentration was significantly lower in patients compared with controls (90.7 ± 37.4 vs. 105.3 ± 50.2 μg/dL,
P = 0.048), but serum iron concentration was significantly lower in controls compared to patients (88.8 ± 39.5 vs. 108.3 ± 48.4 μg/dL,
P = 0.008). Also, there was no significant difference between patients and controls in serum zinc concentration (114.8 ± 67.8
vs. 108.2 ± 49.9 μg/dL, P = 0.285). According to these results, among copper, zinc, and iron, a low serum copper concentration may play a role in premature
graying of hairs in our society. Further studies are needed to find the underlying mechanism of this relationship. 相似文献
7.
Rahman A Azad MA Hossain I Qusar MM Bari W Begum F Huq SM Hasnat A 《Biological trace element research》2009,127(2):102-108
The purpose of the study was to determine the concentration of trace elements present in scalp hair sample of schizophrenic
patients and to find out the relationship between trace elements level and nutritional status or socioeconomic factors. The
study was conducted among 30 schizophrenic male patients and 30 healthy male volunteers. Patients were recruited from Bangabandhu
Sheikh Mujib Medical University by random sampling. Hair trace element concentrations were determined by flame atomic absorption
spectroscopy and analyzed by independent t test, Pearson’s correlation analysis, regression analysis, and analysis of variance (ANOVA). Mn, Zn, Ca, Cu, and Cd concentrations
of schizophrenic patients were 3.8 ± 2.31 μg/gm, 171.6 ± 59.04 μg/gm, 396.23 ± 157.83 μg/gm, 15.40 ± 5.68 μg/gm, and 1.14 ± 0.89 μg/gm
of hair sample, while those of control subjects were 4.4 ± 2.32 μg/gm, 199.16 ± 27.85 μg/gm, 620.9 ± 181.55 μg/gm, 12.23 ± 4.56 μg/gm,
and 0.47 ± 0.32 μg/gm of hair sample, respectively. The hair concentration of Zn and Ca decreased significantly (p = 0.024; p = 0.000, respectively) and the concentration of Cu and Cd increased significantly (p = 0.021; p = 0.000, respectively) in schizophrenic patients while the concentration of Mn (p = 0.321) remain unchanged. Socioeconomic data reveals that most of the patients were poor, middle-aged and divorced. Mean
body mass indices (BMIs) of the control group (22.26 ± 1.91 kg/m2) and the patient group (20.42 ± 3.16 kg/m2) were within the normal range (18.5−25.0 kg/m2). Pearson’s correlation analysis suggested that only Ca concentration of patients had a significant positive correlation
with the BMI (r = 0.597; p = 0.000) which was further justified from the regression analysis (R
2 = 44%; t = 3.59; p = 0.002) and one-way ANOVA test (F = 3.62; p = 0.015). A significant decrease in the hair concentration of Zn and Ca as well as a significant increase in the hair concentration
of Cu and Cd in schizophrenic patients than that of its control group was observed which may provide prognostic tool for the
diagnosis and treatment of this disease. However, further work with larger population is suggested to examine the exact correlation
between trace element level and the degree of disorder. 相似文献
8.
Lucianna Fernandes J. C. Marques Carmen Marino Donangelo Juliana Gastao Franco Luciane Pires Aderval Severino Luna Gustavo Casimiro-Lopes Patricia Cristina Lisboa Josely Correa Koury 《Biological trace element research》2011,142(3):415-423
Intense physical activity is associated with biological adaptations involving hormones and trace elements. Zinc supplementation
may affect plasma copper concentration, thyroid-stimulating hormone (TSH), thyroid hormones, insulin, and glucose homeostasis,
but data in athletes are scarce. The aim of this study was to evaluate in competitive athletes (cyclists, n = 7, 32 ± 8 years) the effect of zinc supplementation (22 mg/day as zinc gluconate) during 30 days, and discontinuation using
placebo (maltodextrin) during the following 30 days, on plasma zinc and copper concentrations, serum thyroid hormones, insulin
and glucose levels, and HOMA2-IR. Compared to baseline, plasma zinc and Zn:Cu plasma ratio increased, but plasma copper decreased
after zinc supplementation (day 30) and discontinuation (day 60) (p < 0.05). Zn supplementation and discontinuation had no effect on TSH, T3, and T4. Fasting serum insulin and HOMA2-IR increased
(27% and 47%, respectively) on day 60 compared to baseline (p = 0.03), suggesting a delayed effect of zinc supplementation. Moreover, plasma zinc was positively associated with serum
insulin (r = 0.87, p = 0.009) and HOMA2-IR (r = 0.81, p = 0.03) after zinc supplementation (day 30), indicating that supplemental zinc may impair glucose utilization in cyclists. 相似文献
9.
Variations of copper (Cu) concentration and ceruloplasmin (Cp) activity in serum and plasma of dairy cows at different stages
of lactation were assessed in 240 Holstein dairy cows. Furthermore, ceruloplasmin to copper ratios were also investigated.
The cows were classified according to their lactation stages into four different groups as close-up stage (3–1 week(s) antepartum),
fresh lactation stage (0–1 week postpartum), early lactation stage (3–5 weeks postpartum), and mid-lactation stage (15–18 weeks
postpartum). Each group consisted of 60 multiparous cows. Serum and heparinised plasma samples were obtained from each cow.
Concentrations of serum copper (sCu) and plasma copper (pCu) as well as activities of plasma Cp (pCp) were higher in the group
of fresh lactation stage than other groups (P < 0.05). Serum Cp (sCp) exhibited no significant difference between fresh lactation and early lactation groups (P > 0.05). Low correlations were obtained between sCp and pCu, sCp and sCu, and sCu and pCu. Plasma copper concentration and
plasma ceruloplasmin activity were higher than serum copper concentration and serum ceruloplasmin activity, respectively (P < 0.001). The ratios of Cp activity to Cu concentration (Cp/Cu) were not significantly changed in the different lactation
stages of dairy cows (P > 0.05). Use of sCp/pCu and sCp/sCu rather than pCp/pCu will reduce the calculated value of Cp/Cu. Furthermore, for evaluation
of copper status, use of sCp/sCu or sCp/pCu identified more animals as ‘low’ and ‘marginal’ than using pCp/pCu (P < 0.001). It can be concluded that ceruloplasmin and copper undergo a physiological increase just after calving; thus, their
values should be interpreted with caution during assessment of copper status. Plasma measurements should be used for calculation
of Cp/Cu, and further research is required to refine diagnosis criteria for use of such ratio in determining copper status
in dairy cows. 相似文献
10.
Previous studies showed that responses to chronic administration of copper were significantly associated with gender, raising
the need to better characterize the relation between the effects observed and stradiols. The objective of this study was to
measure copper and liver function indicators and the sex hormone binding globulin (SHBG) serum concentrations in healthy adults
exposed to copper, grouped by sex and phase of the female hormonal cycle. Healthy females on day 7 (follicular phase, Group
1, n = 39), on day 21 (secretory phase, Group 2, n = 34) and males (comparison group, Group 3, n = 34) received 8 mg Cu/day (as copper sulfate), orally, for 6 months. On days 0, 30, 60, 120, and 180, the serum concentration
of copper, ceruloplasmin, liver aminotransferases, and SHBG were measured. Analysis of results included analysis of variance
(ANOVA; repeated measures) and the post hoc Bonferroni correction. Participants remained healthy throughout the study period,
including aminotransferases below the cut off in all measures. GGT, AST, and ALT activities were significantly different by
group and by time (ANOVA repeated measures P < 0.05). Six-month curves of serum copper and ceruloplasmin concentrations were different by group, by time and interaction
group × time (all P < 0.001). SHBG curves were different by group and time (P < 0.01), and interaction group × time (P < 0.009). Serum copper, ceruloplasmin, and liver aminotranferases are influenced by estrogens/progesterone, something that
should be considered when these indicators are used as outcomes of effects. Time of sampling was also significantly associated
with the indicators and deserves further study. 相似文献
11.
Miguel Arredondo Héctor Núñez Guadalupe López Fernando Pizarro Mariana Ayala Magdalena Araya 《Biological trace element research》2010,134(3):252-264
Classic copper indicators are not sensitive and specific for detecting excess copper exposure when this is higher than customary
but not markedly elevated. Serum copper and ceruloplasmin (Cp) are the most commonly used indicators to assess nutritional
status of copper. The objective of this paper was to study the influence of estrogens on these indicators and others used
to assess early effects of excess copper exposure in humans and the expression of a set of copper related proteins in a hepatic
cellular model. For the studies in humans, 107 healthy participants (18–50 years) were allocated as follows: group 1 (n = 39), women assessed on day 7 of their hormonal cycle; group 2 (n = 34), women assessed on day 21 of their hormonal cycle, and group 3 (n = 34, comparison group), healthy men. Participants received 8 mg Cu/day (as copper sulfate) during 6 months. Serum Cp and
Cu, Cu–Zn–superoxide dismutase activity, liver function indicators [aspartate aminotransferase (AST), alanine aminotransferase
(ALT), and gamma glutamyltransferase (GGT)], and serum Fe and Zn concentrations were measured monthly. In addition, the influence
of estradiol on intracellular total copper content, hctr1, dmt1 and shbg mRNA abundance and hCTR1, and DMT1 expression was
measured in HepG2 cells. Serum Cu, Fe, and Zn and liver aminotransferases but not Cu–Zn–superoxide dismutase varied depending
on sex. Fe nutrition indicators, GGT, and ALT activities showed significant differences between the hormonal phases. Cellular
experiments showed that estradiol increased cellular Cu concentration and hCTR1 and DMT1 mRNA expression and changed these
proteins expression patterns. Estradiols significantly influence the responses to copper at the whole body and the cellular
levels, suggesting that they help maintaining copper availability for metabolic needs. 相似文献
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Casimiro-Lopes G de Oliveira-Junior AV Portella ES Lisboa PC Donangelo CM de Moura EG Koury JC 《Biological trace element research》2009,127(2):109-115
The purpose of this study was to compare plasma leptin, plasma zinc, and plasma copper levels and their relationship in trained
female and male judo athletes (n = 10 women; n = 8 men). Blood samples were obtained 24 h after training to measure plasma zinc, copper, and leptin levels. Subjects presented
similar values to age (22 ± 2 years old), body mass index (24 ± 1 kg/m2), plasma zinc (17.2 ± 2 μmol/L), copper (12.5 ± 2 μmol/L), and leptin (5.6 ± 1.3 μg/L). However, height, total body mass,
lean mass, fat mass, and sum of ten-skinfold thickness were higher in male than female. Plasma leptin was associated with
sum of ten skinfolds in male (r = 0.91; p < 0.001) and female athletes (r = 0.84; p < 0.003). Plasma zinc was associated with leptin in males (r = 0.82; p < 0.05) while copper was associated with plasma leptin in females (r = 0.66; p < 0.05). Our results suggest that young judo athletes lost sex-related differences in leptin levels. Plasma zinc, plasma
copper, and energy homeostasis may be involved in regulation of plasma leptin. 相似文献
14.
Mohammad Abbasi Nazari Farzad Kobarfard Payam Tabarsi Jamshid Salamzadeh 《Biological trace element research》2009,128(2):161-166
Ethambutol is an oral anti-tuberculosis agent with chelating effects owing to its chemical structure which is similar to that
of penicillamine. Copper (Cu) is an essential trace element that has important roles in physiological function of the body
organs. The aim of present study was to determine (1) whether ethambutol usage can alter serum Cu concentration in patients
with tuberculosis and (2) whether there is any relationship between age, sex, and smoking habit of patients with changes in
serum Cu levels. Sixty patients with diagnosis of pulmonary tuberculosis were enrolled the study. Blood samples were obtained
before treatment (baseline) and 10 days after starting anti-tuberculosis therapy. The amounts of serum Cu were determined
in all samples by atomic absorption. Mean ± SD levels of Cu at baseline and on the 10th day of ethambutol use were 0.94 ± 0.24
and 0.64 ± 0.24 μg/mL, respectively. Statistical analysis confirmed a significant difference (p < 0.0001). Also, there was not any relationship between changes in Cu concentration and study variables of age, sex, and
smoking habit. Our findings endorse the chelating effect of ethambutol leading to a decrease in serum levels of cationic trace
elements, e.g., Cu. 相似文献
15.
Effects of Short-Term Over-supplementation of Copper in Milk on Hematology,Serum Proteins,Weight Gain,and Health in Dairy Calves 总被引:1,自引:0,他引:1
Zahra Naseri Mehrdad Mohri Mohammad R. Aslani Ali A. Alavi Tabatabaee 《Biological trace element research》2011,139(1):24-31
Thirty-six calves were used in the present study. The animals were divided equally into three groups (control, test 1, and
test 2). The three groups of calves were homogeneous for parity of dams, sex, and month of birth. From 14 days of age, in
the test 1 group copper as copper sulfate (Merck Co, Germany) was added to each meal of milk at a rate of 10 mg/kg of milk
for 14 days and in test 2 group copper as copper sulfate was added to each meal of milk at a rate of 20 mg/kg of milk for
14 days. Blood samples were taken by jugular venipuncture using disposable syringes at 14 (before Cu supplementation), 30,
60, and 80 days of age. Anticoagulated blood was used for CBC determination. Plane tubes were used for harvesting of serum
and the amounts of total serum protein, albumin, iron, and copper were measured. Calves were weighted at birth and at the
end of trial (day 80) and total gain and mean daily gain were calculated. Days of treatment for ill calves were also recorded
during experiment. Group (treatment) had no significant effect on the amounts of measured parameters except MCH values (p < 0.05) which were significantly lower in test 1 group than other trial groups. Age (sampling time) had significant effects
on the values of most measured parameters (p < 0.05) except WBC, lymphocyte, total protein, and fibrinogen. Significant interactions between sampling time and group were
not seen for any of measured parameters. No significant differences were seen for total weight gain and mean daily gain between
trial groups. Chi-square test revealed no significant difference for the days of treatment between trials groups. 相似文献
16.
Valenzuela C de Romaña DL Schmiede C Morales MS Olivares M Pizarro F 《Biological trace element research》2011,143(3):1489-1496
The aim of this study is to determine the content of total iron (TFe), heme iron (HeFe), zinc (Zn), and copper (Cu) in different
cuts of meat and viscera from rabbit. Five young New Zealand rabbits were used in the study. Samples in triplicate were obtained
from three meat cuts (foreleg, hind leg, and loin) and from main viscera. TFe, Zn, and Cu concentrations from samples were
determined by wet acid digestion followed by atomic absorption spectrophotometry (AAS), while HeFe was determined by acid
extraction followed by AAS. Mean TFe, HeFe, Zn, and Cu in meat was 0.83 ± 0.09, 0.56 ± 0.11, 0.95 ± 0.35, and 0.08 ± 0.01 mg/100 g,
respectively. TFe content was less than 1 mg/100 g in all meat cuts. Sixty-seven percent of iron content was HeFe. The cut
of meat with highest Zn concentrations was the foreleg with 1.33 ± 0.12 mg/100 g. Cu content was low for all meat cuts. TFe,
HeFe, Zn, and Cu content in viscera varied greatly. The spleen was the organ with the highest TFe and Zn concentrations (82.79 ± 9.22 mg/100 g
and 3.49 ± 0.63 mg/100 g, respectively). Nevertheless, the lungs had the highest concentration of HeFe (5.79 ± 0.90 mg/100 g),
accounting for 91% of the total iron. The liver had the highest Cu content (3.89 ± 0.89 mg/100 g). Rabbit meat has low TFe
concentration, similar to that of poultry, and most of the iron is HeFe. The amount of minerals in viscera closely depends
on their function. 相似文献
17.
Gümüş M Yüksel H Evliyaoğlu O Kapan M Böyük A Önder A Aldemir M 《Biological trace element research》2011,143(1):386-393
Ellagic acid (EA) is a natural polyphenolic compound. Although, modulator effects of EA on copper (Cu) and zinc (Zn) levels
in some liver diseases have been reported in experimental animals, its effects in obstructive jaundice (OJ) has not been clarified.
We aimed to evaluate potential effects of EA on Cu and Zn levels in liver and serum of cholestatic rats. Forty Wistar albino
rats were equally divided into four groups. First group was used as controls. Second group received EA (60 mg−1 kg−1 day−1) for 8 days. Third was OJ group, and fourth group was OJ plus EA group. After 8 days, blood and liver samples were obtained.
Higher serum and liver Cu and lower serum and liver Zn levels were found in OJ group (p < 0.05) compared with other groups. However, these differences reached to significant levels for Cu in serum and for Zn in
lever. Higher serum copper levels were decreased, and lower liver Zn levels were increased by EA treatment in cholestatic
rats (p < 0.05). Also, higher Cu/Zn ratio in OJ group was decreased by EA treatment both in liver (p < 0.05) and in serum (p < 0.05). Significantly higher serum bilirubin, alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase
values were found in OJ and OJ + EA groups compared with the control and EA groups (p < 0.05). In conclusion, result of the current study indicated that ellagic acid has modulator effects on Cu and Zn levels
in liver and serum of cholestatic rats. 相似文献
18.
Twenty male buffalo calves (15 months, 200.2 ± 9.75) were divided into four groups of five animals in each and fed diets without
(T1) or supplemented with 0.3 ppm selenium (Se) + 40 ppm zinc (Zn) (T2), 0.3 ppm Se + 40 ppm Zn + 10 ppm copper (Cu) (T3),
and 40 ppm Zn + 10 ppm Cu (T4) for 120 days, during which blood samples were collected on days 0, 40, 80, and 120. Concentrations
of glucose, total protein, albumin, globulin, urea, uric acid, and creatinine were similar in all the four groups. The level
of different serum enzymes viz. lactate dehydrogenase, alkaline phosphatase, glutamate pyruvate transaminase, and glutamate
oxaloacetate transaminase, and hormones viz. T3, T4, testosterone and insulin were similar (P > 0.05) among the four groups but the ratio of T4/T3 was reduced (P < 0.05) in the groups (T2 and T3) where selenium was supplemented at 120th day of supplementation. It was deduced that supplementation
of 0.3 ppm Se and/or 10.0 ppm of Cu with 40 ppm Zn had no effect on blood metabolic profile in buffalo calves, except the
ratio of T4 and T3 hormone which indicates that selenium plays an important role in converting T4 hormone to T3 which is more active form of thyroid hormone. 相似文献
19.
Lu Rongzhu Wang Suhua Xing Guangwei Ren Chunlan Han Fangan Jing Junjie Michael Aschner 《Biological trace element research》2009,130(1):39-47
The mechanism of toxicity of acrylonitrile (AN) has not been fully defined. The research described herein was undertaken to
investigate the possible effects of AN on the levels of metallic elements in liver and brain of mice. Thirty-two mice were
randomly assigned to four separate groups and treated intraperitoneal (i.p.) once daily for 1 week. Mice in the control group
received normal saline, and mice in the three exposure groups received 5, 10, or 20 mg AN/kg b.w. Samples of brain and liver
were collected immediately after decapitation. Tissue levels of trace elements (zinc, copper, iron) were determined with flame
atomic absorption spectrophotometer or double channel atomic fluorescence absorption spectrophotometer (selenium). Mean brain
weights of AN-treated mice were increased as a function of dose compared to controls, but there was no significant change
in the ratio of liver/body weight in the four groups. While mean brain zinc decreased as a function of AN dosage, mean liver
zinc of the low-dose group significantly increased (p < 0.05); mean liver copper in the medium-dose AN group was significantly higher compared to controls (p < 0.05); however, mean brain copper was increased, but the difference did not attain statistical significance in the three
AN groups when compared with the controls (p > 0.05). Mean brain iron levels were significantly decreased in the middle-dose AN group (p < 0.05), but there were no consistent changes in liver iron. Tissue levels of selenium in brain and liver were similar for
the control and AN treatment groups. AN induces significant and differential changes in the levels of zinc, copper, and iron
in brain and liver. These changes likely play a pivotal role in mediating AN toxicity, most likely via changes in cellular
redox status. 相似文献
20.
Güçlü BK Kara K Beyaz L Uyanik F Eren M Atasever A 《Biological trace element research》2008,125(2):160-169
This study was performed to determine the effects of copper proteinate on performance, blood chemistry, lipid peroxidation
status, and organs as well as copper deposition in the liver and eggs of laying hens. Seventy-two 30-week-old Bovans laying
hens were distributed into four groups with three replicates. Animals were fed basal diet containing at least 17% crude protein
and 2,800 kcal/kg metabolizable energy supplemented with either 0, 150, 300, or 450 mg/kg copper as copper proteinate. Supplementation
of 150 and 300 mg/kg copper increased egg production, whereas 450 mg/kg copper decreased (p < 0.001). Liver copper levels were elevated in 300 and 450 mg/kg copper-supplemented groups (p < 0.001). Egg copper contents increased in all treatment groups (p < 0.01). An increase in glucose (p < 0.001) and decreases in albumin (p < 0.01) and total cholesterol (p < 0.05) levels were determined with 300 and 450 mg/kg copper. Supplementation of 450 mg/kg copper increased alkaline phosphatase
and gamma glutamyl transpeptidase activities (p < 0.05), malondialdehyde, and high-density lipoprotein levels (p < 0.01) but decreased alanine aminotransferase and lactate dehydrogenase activities (p < 0.01). No gross and microscopic changes were observed in the liver and kidneys. These results indicated that 150 and 300 mg/kg
copper increased egg production without having marked adverse effects, but 450 mg/kg copper altered some blood chemistry variables
and reduced egg production in laying hens. 相似文献