《生物技术概论》本科教学的实践与探索

《生物技术概论》是我校生物技术专业开设的一门必修专业基础课程。学好这门课程,将为学生今后在生物技术相关领域进行研究或者工作奠定良好的理论和技术基础。作者结合自己在《生物技术概论》课程教学中的亲身体会,对教材选择、教学时间、教学方法、考核方式及课外实践等方面进行了探讨和总结。     

浅谈《二维动画制作》课程实验教学设计与实践

本文首先对《二维动画制作》课程实验教学设计与实践的必要性及意义和该课程实验教学研究现状进行了分析。然后介入本文重点内容,就本人教学实践探索《二维动画制作》课程实验教学设计的具体内容。通过构建《二维动画制作》课程实验教学体系,综合运用企业真实或仿真项目的实践等内容,以达到培养学生动手能力和创新能力的目的。     

“新工科”背景下“生物化工大实验”课程教学设计与实践

“生物化工大实验”是湖南科技学院生物工程专业集中实践教学环节的必修课程,是在“新工科”背景下为提高本专业学生综合素质而开设的实验课程。课程实验项目为综合性实验及设计性实验,其内容主要结合了永州市地方特色资源、研究平台和工科人才特征合理编制而成。授课过程中,综合运用符合课程特点的启发式教学、科研案例导入式教学和互动式教学等方法,提高学生学习的兴趣,激发学生的创新能力和实践应用能力。通过课程考察和课后调查发现,生物工程专业学生的知识迁移和应用能力明显提升,学科竞赛和项目立项成绩优异。因此,基于对本课程授课内容和方法的实践及不断完善,课程教学质量得到了全面提高,为培养生物工程专业高水平创新型、应用型工科人才夯实了基础。     

医学微生物学实验技术教学体系的建设与实践

《医学微生物学及实验技术》是医学实验技术专业的一门重要专业主干课程,该课程的实验技术部分是学生必须掌握的基本技能。经过数年的教学实践,本着培养应用型人才的目标和重实践教学的教学理念,引入企业实践教学,逐步形成了"医学微生物学实验技术"教学体系,由基础性实验、综合性实验、企业实践三部分组成,并初步建立和实施了形成性考核评价体系。教学实践表明,学生较为全面地掌握了医学微生物学实验技术,对全面提高学生的实验实践能力和综合素质有所助益,有效提高了医学微生物学实验技术教学效果。     

“观赏渔业”课程教学的实践与探索

《观赏渔业》是新兴"水族科学与技术"本科专业学生的专业核心课程,也是水产养殖学专业课程体系中的重要组成。结合作者多年在《观赏渔业》课程教学中的实践和探索,以培养学生对观赏水族的兴趣为本,通过对教学方法的创新、实践教学的注重,极大地激发了学生对该课程的兴趣,充分调动了学生学习和实践的积极性与主动性,增强该课程实践功能促进了教学效果的提高。同时,这对培养水族专业人才,满足中国现代水族产业发展对高素质人才的需要亦具有重要的作用。     

开设综合研究型实验课的实践与体会

提高学生的综合和创新能力,激励学生的求知欲和探索精神是当今教育改革的首要课题。我校开设了综合研究型实验课——医学机能实验学,本课程整合了生理学和病理生理学两门课程,将这两门课程的实验教学部分从原课程中分离出来,科学有机的整合成一门新型的独立综合研究型课程。通过此课程的教学,发挥学生的积极性和能动性,使学生初步具有应用知识和实践能力,培养学生的科研和创新能力。     

探究病原微生物与免疫学实验操作考核体系

病原微生物与免疫学的学习对实践有着较高的要求,这就要求学校积极开展实践教学活动,提高学生的实践能力,促使他们的创新思维得以激发,使学科间的纵向联系、横向联系增强。病原微生物与免疫学知识的学习实际上是对寄生虫学、医学微生物学、免疫学三门课程的整合、优化,开设病原微生物学与免疫学课程,能够防止教学过程中出现重复性内容,并且突破了传统的实验教学课程,有利于培养更多优秀的复合型人才。     

《酶工程》教学与课程建设的探讨

酶工程是生物技术专业的主干课程,其主要内容是研究酶的生产和应用。为了使酶工程的教学适合时代发展的需要,培养合格的从事酶工程研究及生产的技术人才,以多年酶工程教学实践为基础,集中介绍该门课程教学与建设的体会及其思考。     

关于《园林植物栽培与养护》课程中项目教学法的应用研究

随着近些年以来我国高度重视环境保护工作,这就使得园林专业逐渐成为一门热门专业,在该专业当中,《园林植物栽培与养护》是其中特别重要的一门专业技能课程,具备特别强实践性与综合性,其专业技能的掌握关系学生未来就业前途,在此背景下,应该对该门课程在教学过程中采用的教学方法进行持续不断的改革,还要做到将其教学理念实施更新,使教学环节必须更为紧贴生产。通过生产式教学的积极开展,将模块式教学方式加入到《园林植物栽培与养护》课程的教学与改革过程,加大相应的实践教学比重,高度重视完善学生的能力与知识,能为学生综合职业能力的培养发挥特别重要的作用。     

现代微生物学研究生课程教学改革与实践——专题教学与seminar教学模式相结合

现代微生物学是面向基础医学专业硕士研究生开设的一门专业基础课程,旨在培养学生的基本科研素养和科研创造力,而传统的讲授型授课方式已无法满足新时代医学研究生教育要求。因此,本文通过专题教学与seminar教学模式(“讨论课”教学模式)相结合,设置六大专题板块辅以学生seminar汇报讨论,应用于现代微生物学研究生课程教学,探讨该教学实践的应用效果,全面提升医学研究生的知识理论水平,培养具有创新思维和具备基本科研素质的高层次医学人才,也为医学类专业其他研究生课程的教学改革提供有益参考。     

Recent advances in the study of Kaposi's sarcoma-associated herpesvirus replication and pathogenesis

It has now been over twenty years since a novel herpesviral genome was identified in Kaposi's sarcoma biopsies. Since then, the cumulative research effort by molecular biologists, virologists, clinicians, and epidemiologists alike has led to the extensive characterization of this tumor virus, Kaposi's sarcoma-associated herpesvirus(KSHV; also known as human herpesvirus 8(HHV-8)), and its associated diseases. Here we review the current knowledge of KSHV biology and pathogenesis, with a particular emphasis on new and exciting advances in the field of epigenetics. We also discuss the development and practicality of various cell culture and animal model systems to study KSHV replication and pathogenesis.     

A Unique Protease Cleavage Site Predicted in the Spike Protein of the Novel Pneumonia Coronavirus (2019-nCoV) Potentially Related to Viral Transmissibility

正Dear Editor,In December 2019, a novel human coronavirus caused an epidemic of severe pneumonia(Coronavirus Disease 2019,COVID-19) in Wuhan, Hubei, China(Wu et al. 2020; Zhu et al. 2020). So far, this virus has spread to all areas of China and even to other countries. The epidemic has caused 67,102 confirmed infections with 1526 fatal cases     

Curcuminoids as inhibitors of thioredoxin reductase: A receptor based pharmacophore study with distance mapping of the active site

Curcumin is the yellow pigment of turmeric that interacts irreversibly forming an adduct with thioredoxin reductase (TrxR), an enzyme responsible for redox control of cell and defence against oxidative stress. Docking at both the active sites of TrxR was performed to compare the potency of three naturally occurring curcuminoids, namely curcumin, demethoxy curcumin and bis-demethoxy curcumin. Results show that active sites of TrxR occur at the junction of E and F chains. Volume and area of both cavities is predicted. It has been concluded by distance mapping of the most active conformations that Se atom of catalytic residue SeCYS498, is at a distance of 3.56 from C13 of demethoxy curcumin at the E chain active site, whereas C13 carbon atom forms adduct with Se atom of SeCys 498. We report that at least one methoxy group in curcuminoids is necessary for interation with catalytic residues of thioredoxin. Pharmacophore of both active sites of the TrxR receptor for curcumin and demethoxy curcumin molecules has been drawn and proposed for design and synthesis of most probable potent antiproliferative synthetic drugs.     

The structure, reproduction and taxonomy of Vidalia and Osmundaria (Rhodophyta, Rhodomelaceae)

Comprises species occurring mostly in subtidal habitats in tropical, subtropical and warm-temperate areas of the world. An analysis of the type species, V. spiralis (Sonder) Lamouroux ex J. Agardh, a species from Australia, establishes basic characters for distinguishing species in the genus. These characters are (1) branching patterns of thalli, (2) flat blades that may be spiralled on their axis, (3) width of the blade, (4) primary or secondary derivation of sterile and fertile branchlets and (5) position of sterile and fertile branchlets on the thalli. Application of the latter two characters provides an important basic method for separation of species into three major groups. Osmundaria , a genus known only in southern Australia, was studied in relation to Vidalia , and its separation from the Vidalia assemblage is not accepted. Species of Vidalia therefore are transferred to the older genus name, Osmundaria. Two new species, Osmundaria papenfussii and Osmundaria oliveae are described from Natal. Confusion in the usage of the epithet, Vidalia fimbriala Brown ex Turner has been clarified, and Vidalia gregaria Falkenberg, described as an epiphyte on Osmundaria pro/ifera Lamouroux, is revealed to be young branches of the host, Osmundaria prolifera.     

New or rare chromosome counts in Artemisia L. (Asteraceae, Anthemideae) and related genera from Kazakhstan

Fifteen chromosome counts of six Artemisia taxa and one species of each of the genera Brachanthemum, Hippolytia, Kaschgaria, Lepidolopsis and Turaniphytum are reported from Kazakhstan. Three of them are new reports, two are not consistent with previous counts and the remainder are confirmations of very scarce (one to four) earlier records. All the populations studied have the same basic chromosome number, x = 9, with ploidy levels ranging from 2x to 6x. Some correlations between ploidy level, morphological characters and distribution are noted.