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Structural organization of the human CaMIII calmodulin gene 总被引:4,自引:0,他引:4
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The functional human dihydrofolate reductase gene 总被引:54,自引:0,他引:54
M J Chen T Shimada A D Moulton A Cline R K Humphries J Maizel A W Nienhuis 《The Journal of biological chemistry》1984,259(6):3933-3943
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D M Gorman N Itoh N A Jenkins D J Gilbert N G Copeland A Miyajima 《The Journal of biological chemistry》1992,267(22):15842-15848
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Molecular organization of the human cathepsin D gene 总被引:4,自引:0,他引:4
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A 14 kilobase (kb) genomic clone of the gene for bovine elastin, containing exons 1 and 2, has been characterized. This clone extends about 6.5 kb in the 5' direction from the initiation codon and 978 nucleotides in the 3' direction from exon 2. The size of the first intron is about 6.4 kb. The sequence immediately 5' to the initiation codon is highly conserved between the genes for bovine and human elastins and contains a TATA box consensus sequence (ATAAA), CAAT, and Sp1 binding sites. Several putative AP-2 binding sites are also present. Comparative analysis of the sequences flanking the first exon in the genes for bovine and human elastins identified conserved sequences that may be regulatory control elements. A putative enhancer core sequence is present in the first intron of the genes for bovine and human elastins. 相似文献