共查询到20条相似文献,搜索用时 15 毫秒
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Clerc I Polakowski N André-Arpin C Cook P Barbeau B Mesnard JM Lemasson I 《The Journal of biological chemistry》2008,283(35):23903-23913
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Acetylation of nucleosomal histones by p300 facilitates transcription from tax-responsive human T-cell leukemia virus type 1 chromatin template 下载免费PDF全文
Lu H Pise-Masison CA Fletcher TM Schiltz RL Nagaich AK Radonovich M Hager G Cole PA Brady JN 《Molecular and cellular biology》2002,22(13):4450-4462
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Human T-cell leukemia virus type 1 Tax transactivates the human proliferating cell nuclear antigen promoter. 总被引:10,自引:4,他引:6 下载免费PDF全文
The human T-cell leukemia virus type 1 (HTLV-1) transforming protein, Tax, is a potent transactivator of both viral and cellular gene expression. The ability of Tax to transform cells is believed to depend on its transactivation of cellular-growth-regulatory genes. Expression of proliferating cell nuclear antigen (PCNA) is intimately linked to cell growth and DNA replication and repair. By testing a series of PCNA promoter deletion constructs, we have demonstrated that the PCNA promoter can be transactivated by Tax. The smallest construct that was activated did not include the ATF/CRE binding site at nucleotide -50, and mutations in the ATF/CRE element in the context of a larger promoter were still activated by Tax. In addition, a Tax mutant that is defective for activation of the CRE pathway retained the ability to activate the -397 promoter construct. When a series of linker scanner mutations that span the region from nucleotide -45 to -7 were assayed, mutations in and around a repeat sequence were found to abolish Tax transactivation. Multimerized copies of either half of the repeat were Tax responsive. A single protein complex was shown to bind specifically to the Tax-responsive region, and the binding of this complex was enhanced in the presence of Tax. These results demonstrate that the PCNA promoter contains a Tax-responsive element located between nucleotides -45 and -7 whose sequence is different from those of other, previously identified Tax-responsive elements. The ability of Tax to activate the PCNA promoter may play an important role in cellular transformation by HTLV-1. 相似文献
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Nguyên TL Calomme C Wijmeersch G Nizet S Veithen E Portetelle D de Launoit Y Burny A Van Lint C 《The Journal of biological chemistry》2004,279(33):35025-35036